Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"regulatory programs"”.
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Integrative analysis of transcriptional regulatory programs in mammalian systems
Gene regulatory network (GRN) is the most central known information processing program of life. To understand its importance and complexity, it is sufficient to note that all the cells in our body contain the same genetic code yet carry out functions ranging from energy storage to immune response. …
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Development Of Single-Cell Transcriptomic & Epigenomic Sequencing Technologies To Assess Cell-Type-Specific Gene Regulatory Programs In Mammalian Brains
… base-ambiguity to fully understand epigenetic regulatory mechanisms in 5hmC-enriched cells.
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Design and Evaluation of Permit Programs for Regulating Surface Water Withdrawal Under Riparian Legal System
"Evaluation of two regulatory programs conducted for the three quantifiable objectives concludes that the fixed flow program is able to provide higher net benefit but more significant low flow frequency and withdrawal interruption frequency than the fractional flow program which rarely changes the …
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The economic impacts of alternative underground storage tank regulations on the vulnerable segments of the retail motor fuel market in Virginia
… the economic impacts that alternative UST regulatory programs would have on the retail motor fuel market in the United States, with emphasis, where possible, on this market in Virginia. The market is broken into five segments based on similar economic and management characteristics. The …
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Evolution of water supply mechanisms to reflect changing values: a case study of the Massachusetts water management program
… State’s water supply policy, legislation, and regulatory programs.
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Gene network understanding and analysis
Gene regulatory network (GRN) is a collection of regulators that interact with each other in the cell to govern the gene expression levels of mRNA and proteins. These regulators can either be DNA, RNA, protein and their complex. Transcriptional gene regulation is an important mechanisms in which an …
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Why did they comply while others did not? : environmental compliance of small firms and implications for regulation
… and social factors. Nevertheless, existing regulatory enforcement strategies have focused heavily on rational/economic factors without considering the significant effects of interactions between the two and consequently failed to produce the behavior they seek. Starting from an examination …
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Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… time secure a stem cell reservoir, intricate regulatory programs have evolved to control multi-lineage differentiation and self-renewal in haematopoietic stem and progenitor cells. Leukaemogenic mutations commonly disrupt these regulatory programs causing a block in differentiation with …
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Computational analysis of regulatory networks using genome-scale data
Living cells are the product of gene expression programs involving regulated transcription of thousands of genes. In single-celled organisms such as S. Cerevisiae regulatory networks respond to the external environment, optimizing the cell at a given time for survival in this environment. Thus a …
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Clonal architecture and genetic regulation of the developing mammalian cerebral cortex
… describe our work investigating changes in gene regulatory programs that are important for brain development over the course of mammalian and human-specific evolution.
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Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression
… proposes that these components are part of a regulatory system that is capable of supporting multiple homeostatic regimes that, in turn, give rise to self-sustaining psychological behaviors. This project hypothesizes that such alternate regulatory programs may play a role in perpetuating …
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Development Of An Avian Index Of Biological Integrity For Kentucky Wetlands
… an existing rapid assessment method used in regulatory programs. Birds are useful indicators because they are sensitive to environmental changes, abundant in various landscapes, occupy higher trophic levels, and can be sampled in a cost-effective manner. Breeding bird point count data from …
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The influence of brand-equity mascots used by U.S. food, beverage, and restaurant companies on the diet of American children and parents
… Advertising Initiative (CFBAI), an industry self-regulatory program. Products were evaluated using seven nutrient-profile models or nutrition guidelines. Results showed that all twenty products that used brand mascots failed to meet one or more of the guidelines, especially for candy/sweets, …
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Investigating the Role of Muscleblind-Like 1 in the Suppression of Breast Cancer Progression
… The interactions between messenger RNA cis-regulatory elements and trans-factors control coordinated gene expression states. Posttranscriptional regulatory programs that enhance metastatic capacity are selected for during cancer progression. In this study, the RNA binding protein …
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Computational regulatory genomics : motifs, networks, and dynamics
… sequence elements and regulators responsible for regulatory programs. In particular, we develop new computational approaches to (1) predict the binding sites of regulators using the genomes of many, closely related species; (2) understand the sequence motifs associated with transcription factors; …
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Computational Dissection of Composite Molecular Signatures and Transcriptional Modules
… down to DNA sequence level to identify gene regulatory programs by integrating gene expression data and protein-DNA binding data. A sparse hidden component model is first developed for this problem, taking into account a well-known biological principle, i.e., a gene is most likely regulated …
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Approaches and Barriers to Incorporating Sustainable Development Into Coal Mine Design
… approaches allows for the incorporation of regulatory and sustainability factors into coal mine design. Graphical approaches, based on the use of GIS tools, are shown as examples of the development of models for the positive and negative impacts of coal mining operations. However, this work …
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THE ESTABLISHMENT OF THE NEW REGULATORY AGENCIES: INDEPENDENT COMMISSION VERSUS EXECUTIVE DEPARTMENT AGENCIES
… an independent commission to administer some regulatory programs while for others it chooses a departmental agency? Systematic research on this question is notably absent despite the emphasis given organizational arrangements by executive branch reform efforts, specifically those proposed by …
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Investigation of Methane Emissions and Sources
… of this study supplied valuable references for regulatory programs, regional emission inventories, and atmospheric model inputs.
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An Examination of Celebrity Endorsement Used to Promote Branded Food and Beverage Products to American Children, Adolescents and Young Adults to Inform Policies to Promote Healthy Food Environments
… existing government policies and industry self-regulatory programs in the United States (US) do not adequately protect young Americans from celebrity endorsement that promotes energy-dense and nutrient-poor food and beverage products. This PhD dissertation describes four studies that examine the …
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