Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"regulatory pathway"”.
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Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer
… involved in mitophagy is the PINK1-PARKN pathway. However, studies often rely on severe mitochondrial damage using CCCP that is considered non-physiological. To find novel regulators of mitophagy in mammalian cells, we used a previously published screen for autophagy regulators to identify …
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Consequences of stochastic mrna synthesis in a gene regulatory pathway
… how does this variation propagate in a gene regulatory pathway, when protein products of an upstream gene, or a pair of upstream genes, aids in the expression of downstream genes? Does variation in the expression of upstream genes affect the expression of downstream genes? These questions are …
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Sucrose -Mediated Transcriptional Regulation of Proton /Sucrose Symporters in Source Leaves of Sugar Beet and Arabidopsis Thaliana
… supports the hypothesis that a sucrose-mediated regulatory pathway common to at least two plant families acts as a key step in regulating assimilate partitioning by modulating phloem loading in response to changing levels of sink demand. Also, symporters that are members of two discovered sucrose …
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The Gsk-3Β-Fbxl21 Axis Regulates Tcap Via Ubiquitin-Mediated Proteasomal Pathway In The Cytoplasm
… These results revealed a new circadian regulatory pathway that FBXL21 regulates TCAP via ubiquitin-mediated proteasomal pathway in the cytoplasm coordinatively with GSK-3β.</p>
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A study on PIP5Kalpha degradation by Nedd4-1-mediated ubiquitination
… working as another route for such a regulatory pathway. We found that PIP5Kα, an isoform of PIP5K, interacts with Nedd4-1, a HECT domain-containing ubiquitin E3 ligase, and undergoes proteasomal degradation via Nedd4-1-mediated polyubiquitination at lysine 88, which leads to reduction …
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A comprehensive guide to the three biosimilar markets (Europe, US, Japan) and the regulatory pathways
… and providing legislation for an abbreviated regulatory pathway for generic drugs. The conversation has shifted to the need to implement similar regulatory paths for generics of biologics. First generation biologic patents have or are geared to expire within the next five years, providing a …
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Elucidating the Function of Krüppel Homolog 1 (Kr-h1) Associated Proteins (KAPs) in Aedes aegypti Reproduction Through RNA Interference-Mediated Downregulation
… how this interaction regulates gene expression pathways critical for mosquito reproduction. Utilizing RNA interference (RNAi), the research identifies DP-1 as a significant regulator of follicle growth post-eclosion (PE), highlighting its vital role in the mosquito reproductive regulatory …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
… (EMT) and migrates into the myocardium. The pathways and mechanisms regulating epicardial derived cell (EPDC) development remain largely unknown. Using mice with epicardial specific deletions of the PDGF receptors, I discovered that these receptors control EPDC fate and epicardial EMT. I …
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Post-Transcriptional Regulation by microRNAS in Pregnancy and Parturition
… of biochemical events that activate inflammatory pathways and negatively impact PR function. In this study, we uncovered a new regulatory pathway whereby miRNAs serve as hormonally-modulated and conserved mediators of contractile gene regulation in the pregnant uterus from mouse to human. Using …
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Regulation of mitotic exit in Saccharomyces cerevisiae
… identification and characterization of a novel regulatory pathway, termed the Cdc fourteen early anaphase release (FEAR) network, which regulates the activation of Cdcl4 during early anaphase. I found that at the onset of anaphase, the FEAR network initiates the release of Cdc 14 from its …
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Biosimilars: A New Look on Process Innovation and the Impact of Competitive Dynamics
… of the cost, governments have created biosimilar regulatory pathways in attempt to lower the costs of biologics. Biosimilars may be viewed as a “pure” or distinct type of process innovation completely separate from product innovation due to the Regulatory requirements and this novel phenomenon …
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
… In the second part of this thesis, a novel Rho-regulatory pathway which includes the Rho-GEF Lfc and its negative regulator Tctex-1 were also found to regulate neurogenesis, potentially by directing mitotic spindle orientation during precursor divisions, thereby regulating the symmetric and …
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Single Nucleotide Polymorphisms Linked to Essential Hypertension in Kasigau, Kenya
… of the renin angiotensin system, the primary regulatory pathway in humans controlling BP. They include: AGT (rs699), AGTR1 (rs5186), and HSD11β2 (rs5479). Overall, by using a fluorescent-based RT-PCR technique, the genotype distribution of AGT (rs699) was 0.63 C/C, 0.34 C/T, and 0.03 T/T. When …
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REGULATION OF DEFENSE RESPONSES MEDIATED BY BON1 AND BAP2 IN ARABIDOPSIS THALIANA
… characterization of a new component in the BON1 regulatory pathway and our efforts in probing the biochemical activities of BAP2 in regulating defense responses.
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… of infections. However, in the absence of active regulatory mechanisms, this protective response can lead to immune pathology. The cytokine interleukin (IL)-27 is required for control of exaggerated immune responses during toxoplasmosis and other infections and autoimmune settings. Multiple …
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Transcriptomics-based study reveals a novel link between arginine methylation and phosphate regulation in Saccharomyces cerevisiae
… interactions. Despite its well-studied role in regulatory processes, the effects of Hmt1 knockout on the transcriptome has never been performed. This thesis investigated the changes in the transcriptome upon deletion of Hmt1, and through this, aimed to uncover as yet undiscovered biological …
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
… experiment is still needed to investigate the regulatory pathway between UCP3 and DNA methylation. The physiological role of UCP3 in defending against cancer, diabetes and obesity has been investigated, but the mechanisms how UCP3 protect the organism from these diseases have not been …
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Using a chemical genetics approach to dissect the nitrogen signalling pathway in Arabidopsis
… genetics approach to investigate the feedback regulatory pathway that links the plant’s N status to expression of the NRT2.1 nitrate transporter gene. A novel chemical screening platform was developed that was designed to be used in conjunction with Arabidopsis lines expressing luciferase …
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Role of Aryl Hydrocarbon Receptor in Circadian Rhythm: A Novel Pathway to Dioxin Toxicity
… the molecular clockwork, especially in the light-regulatory pathway of circadian rhythm; exposure to environmental contaminants that interact with AhR may affect the ability of humans and animals to adjust their circadian rhythm to the external environment. Although further studies are necessary …
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Regulation of Bidirectional Microtubule-Dependent Organelle Transport in Xenopus Laevis Melanophores
… axis-determination. Therefore, understanding the regulatory mechanisms that govern this transport can provide important insights into cellular functions, and can aid in the identification and treatment of diseased states of the cell. An excellent model system in which to study regulated transport …
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