Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 307 for “"regulatory networks"”.
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Design of genetic regulatory networks
… we present two approaches for designing genetic regulatory networks in the field of synthetic biology. The core problem is to capture topological properties and dynamical mechanisms in such a way that enables generation of large-scale and complex genetic regulatory networks. Synthetic biologists …
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Supervised Inference of Gene Regulatory Networks
A gene regulatory network (GRN) records the interactions among transcription factors and their target genes. GRNs are useful to study how transcription factors (TFs) control gene expression as cells transition between states during differentiation and development. Scientists usually construct GRNs …
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Robustness Analysis of Gene Regulatory Networks
… robustness. First, the special topology of gene regulatory networks (GRNs) seems to be an important factor as they possess feedforward loops and certain other topological features much more frequently than expected. Second, genes often regulate each other in a canalizing fashion: there exists a …
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Gene Regulatory Networks in Striated Muscle Pathologies
… blood throughout the body (cardiac muscle). Gene regulatory networks, the interactions between lineage or stage-determining transcription factors and the mRNAs they govern, tightly control cell function and striated tissue development and homeostasis. A disruption or change in these complex …
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ELUCIDATING REGULATORY NETWORKS PROMOTING B-CELL DEVELOPMENT
B-cells are an essential part of our adaptive immune system. A network of transcription factors together with external signals facilitate the gradual developmental progression from progenitor cells towards the B-cell fate. Several key factors participating in this network have been identified. …
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Simulation and identification of gene regulatory networks
Gene regulatory networks are a well-established model to represent the functioning, at gene level, of utterly elaborated biological networks. Studying and understanding such models of gene communication might enable researchers to rightly address costly laboratory experiments, e.g. by selecting a …
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Representation and visualization of genetic regulatory networks
… and manipulation of transcriptional regulatory networks in yeast. Sonnet is particularly well adapted to this application as native presentation of these networks yields dense and difficult to decipher results.
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Noise and multistability in gene regulatory networks
… other and bind to DNA to form so-called gene regulatory networks and in this way regulate the level, location and timing of expression of other proteins. Cells implement feedback loops to create a memory of their gene expression states. In this way, every differentiated cell in a multicellular …
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Evolution and statistics of biological regulatory networks
… I study the process of evolution of the gene regulatory network in Escherichia coli. First, I characterize the portion of the network that has been documented, and then I simulate growth of the network. In this study, I assume that the network evolves by gene duplication and divergence. …
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Algebraic Methods for Modeling Gene Regulatory Networks
… methods for modeling and analysis of gene regulatory networks within the discrete modeling context. The first chapter gives a background for discrete models and put in context some of the main research problems that have been pursued in this field for the last fifty years. It also outlines …
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Dynamics of molecular fluctuations in gene regulatory networks
… of one another, thereby forming large gene regulatory networks that perform specific cellular functions. The complex connectivity between genes of a network could result in various behaviours that are interesting. The assumption then is that tracking subnetwork behaviour helps understand the …
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Regulatory networks of host defense against Borrelia burgdorferi
Contains fulltext : 207619.pdf (Publisher’s version ) (Open Access)
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Gene regulatory networks controlling an epithelial-mesenchymal transition
… states of the sequentially progressing PMC gene regulatory network (GRN) controls the EMT process during PMC ingression. Transcriptional regulators such as Snail and Twist have emerged as important molecules for controlling EMTs in many model systems. Sea urchin snail and twist genes were cloned …
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Dissecting Transcriptional Regulatory Networks with Systems Biology Approaches
… using systems biology approaches. Transcription regulatory networks play an important role in mediating external stimuli and coordinating responses to changing environments. Different methods that infer regulatory interactions directly from microarray data have been developed in the recent past. …
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Model Composition and Aggregation in Macromolecular Regulatory Networks
Mathematical models of regulatory networks become more difficult to construct and understand as they grow in size and complexity. Large regulatory network models can be built up from smaller models, representing subsets of reactions within the larger network. This dissertation focuses on novel …
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Reconstructing gene function and gene regulatory networks in prokaryotes
… has been to better understand bacterial genetic regulatory networks, which conceptually consist of nodes (the genes) and edges (the interactions between the genes). Two problems are addressed, one focusing on the nodes in the network, the other focusing on the edges. The problem concerning the …
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Computational analysis of regulatory networks using genome-scale data
… In single-celled organisms such as S. Cerevisiae regulatory networks respond to the external environment, optimizing the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to …
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Inferring regulatory networks from multiple sources of genomic data
(cont.) algorithm to identify the regulatory models from protein-DNA binding and gene expression data. These models to a large extent agree with the knowledge of gene regulation pertaining to the corresponding regulators. The three works in this thesis provide a framework of modeling gene …
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Cellular computation and communications using engineered genetic regulatory networks
In this thesis, I present an engineering discipline for obtaining complex, predictable, and reliable cell behaviors by embedding biochemical logic circuits and programmed intercellular communications into cells. To accomplish this goal, I provide a well-characterized component library, a biocircuit …
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