Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 239 for “"regulatory network"”.
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Elucidation of the Cardiac Myogenesis Regulatory Network
… development, we have a critical need for global network views of heart development processes conducted within one species.Cardiac myogenesis, the development of heart muscle cells, is the earliest heart development process and is required for the formation of all adult heart structures. Key …
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Towards causality in gene regulatory network inference
… a series of methods for uncovering gene regulatory relationships underlying cellular identity and function from single-cell data. Firstly, we present a framework for enhancing the detection of statistical associations in small sample size settings for gene regulatory network inference. We …
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Extending Regulatory Network Modeling with Multistate Species
… level of abstraction in the representation of regulatory network models, we can hope to allow modelers to create models that are beyond the threshold of what can currently be expressed reliably. As hundreds of reactions are difficult to understand, maintain, and extend, thousands of reactions …
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Unsupervised gene regulatory network inference on microarray data
Obtaining gene regulatory networks (GRNs) from expression data is a challenging and crucial task. Many computational methods and algorithms have been developed to infer gene networks for gene expression data, which are usually obtained from microarray experiments. A gene network is a method to …
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In silico bacterial gene regulatory network reconstruction from sequence
… notorious example is in the area of gene regulatory networks. A molecular study of gene regulation proceeds one protein at a time, requiring bench scientists months of work purifying transcription factors and performing DNA footprinting studies. Massive scale options like ChIP-Seq and …
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Dissecting the transcriptional regulatory network of embryonic stem cells
… An understanding of the transcriptional regulatory networks that establish and maintain gene expression programs in mammalian cells is fundamental to understand development and should provide the foundation for improved diagnosis and treatment of disease. Although it is not yet feasible …
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Functional Analysis of the miR156 Regulatory Network in Arabidopsis Siliques
… PROMOTER BINDING PROTEIN-LIKE (SPL) network is involved in regulating plant growth and development, but the downstream genes of this network are still not fully elucidated. Here, I show that the miR156/SPL2 pathway controls the development of floral organs, regulates pollen …
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Dissecting the Transcriptional Regulatory Network Underlying Plant Wound Suberin Biosynthesis
… suberin biosynthesis have been identified, the regulatory components controlling its biosynthesis and deposition are only now beginning to be deciphered. The overall objective of this dissertation is to decipher the transcriptional regulators of suberin biosynthesis with a particular emphasis on …
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Gene regulatory network modelling with evolutionary algorithms -an integrative approach
… data that has become available. Models represent regulatory interactions between genes and transcription factors and can provide better understanding of biological processes, and means of simulating both natural and perturbed systems (e.g. those associated with disease). Gene regulatory network …
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The Arabidopsis thaliana Heat Shock Transcription Factor A1b Transcriptional Regulatory Network
… the initiation of complex transcriptional regulatory circuits. The heat shock transcription factors (HSFs) have been shown to be central regulators of plant responses to abiotic and biotic stress conditions. However, the extremely high multiplicity in plant HSF families compared to those of …
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Algorithms for regulatory network inference and experiment planning in systems biology
… comprehensive mathematical model of the protein regulatory network controlling cell division in budding yeast. (ii) I formulate several natural problems related to efficient synthesis of a target mutant from source mutants. These formulations capture experimentally-useful notions of verifiability …
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A Mathematical Model of the Iron Regulatory Network in Aspergilus Fumigatus
… virulence. Furthermore, mechanisms in the iron regulatory network are believed to be potential drug targets since iron management in fungi is vastly different from that in mammals and other eukaryotes. Therefore a better understanding of iron homeostasis in Aspergillus fumigatus could help …
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Characterisation of the gene regulatory network for posterior segmentation in Parasteatoda tepidariorum
… of components and the architecture of the gene regulatory network that controls the formation of the segment addition zone (SAZ) and posterior segments in the spider Parasteatoda tepidariorum. Analysis of the formation and function of the SAZ among arthropods suggests that Wnt and Delta-Notch …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… in this dissertation provide new data about the regulatory network at play controlling the migrations of the Q neuroblasts and their descendants. We have described new roles of genes which furthers our understanding of the genetic mechanisms at play. These new data give insights into the complex …
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Regulatory network built by Cytochrome c with Histone Chaperones in response to DNA damage
… lesions, living beings have developed a complex network called DNA damage response (DDR), which encompasses an intricate phosphorylation signalling cascade, enabling a quick DNA damage repair. To control this signalling cascade and to avoid an illegitimate activation, this network is tightly …
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A dynamic transcriptome technique for transcriptional profiling and gene regulatory network involving the helicase antigen (HAGE)
… drugs. Therefore, it is possible signalling networks could be influenced by as yet unknown molecules or known mediators with function that have not yet been described. As a result of this, work must continue to improve knowledge yet further to allow the design of novel therapies to aid in the …
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Integrating biclustering techniques with de novo gene regulatory network discovery using RNA-seq from skeletal tissues
… Identifying key regulators in the gene regulatory networks (GRNs) driving cartilage and bone development and the differences in the GRNs they drive will facilitate a means to make comparisons between the tissues at the transcriptomic level. Due to a small number of available samples for …
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The Role of the TBX5-driven Regulatory Network in the Manifestation and Sustainability of Atrial Fibrillation
… embryogenesis. The multi-tier transcriptional network driven by TBX5 and modulated by PITX2 links 7 AF loci. This regulates many gene expressions, which play a crucial role in AF susceptibility. The exact mechanism underlying AF due to the genetic impairment and mutations is not well …
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