Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"regulatory landscape"”.
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Characterising the gene regulatory landscape of CD4+ T cells
… association studies (GWAS) overlap with active regulatory elements in CD4+ T cells, and particularly in regulatory T cells (Tregs). CD4+ T cells are the orchestrators of the adaptive immune response and their dysfunction has been associated with immune-mediated disorders through uncontrolled …
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Large replisome-dependent heterochromatic domains defining the transgenerational regulatory landscape
… large disruptions to the heterochromatin landscape and changes in gene expression. Some of these changes form clusters of both gene and transposable element activation, resting on specific domains I named “corrie” domains. These domains sit on the border between a low and a high H3K9me3 …
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The current regulatory landscape of nanomedicines and future perspectives: A scoping review
Υπόβαθρο: Τα νανοσωματίδια διαθέτουν μοναδικές ιδιότητες, όπως υψηλό λόγο επιφάνειας προς όγκο, διαστάσεις νανοκλίμακας και δυνατότητα λειτουργικοποίησης, γεγονός που τα καθιστά ιδιαίτερα κατάλληλα για ποικίλες βιοϊατρικές εφαρμογές, όπως η χορήγηση φαρμάκων, η διάγνωση και οι στοχευμένες …
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Leveraging genomic and molecular variations to understand the regulatory landscape in human cancers and differentiating stem cells
… gene expression levels. We describe the tumours' regulatory landscape that is highly heterogeneous across cancer types, and quantify the relationship between gene expression and various genetic features that characterise local and global mutational burden as well as distinct mutational processes. …
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Decoding Financial Inclusion in a Post-War Jurisdiction Sri Lanka: A Case Study
… the complex interplay between the financial regulatory landscape and financial inclusion in a post-war jurisdiction. The global debates surrounding the deployment of financial inclusion initiatives virtually center on many legal and non-legal discourses, thereby making this a significant …
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3D chromosome structure and chromatin proteomics
… here describes the generation of 3D chromosome regulatory landscape maps of human naive and primed embryonic stem cells. To create these 3D chromosome regulatory landscape maps, genome-wide enhancer and insulator locations were mapped and then placed into a 3D interaction framework formed by …
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Systems analysis of Crassulacean acid metabolism (CAM) physiology and molecular biology
The main theme of this thesis was to explore the regulatory landscape of CAM using systems biology approaches. The scope of the regulatory landscape was drawn around the mesophyll metabolism of the dicotyledonous obligate CAM genus, *Kalanchoe*, even though the computational frameworks that had …
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INTEGRATIVE GENOMICS UNVEILS TRANSCRIPTION FACTOR ROLES IN CELLULAR FATEAND SPATIALLY RESOLVED TRIPLE-NEGATIVE BREAST CANCER IMMUNITY CAPACITY
… conversion strategies due to the complex TF regulatory landscape. We developed a comprehensive screening of 130 developmental TFs, comparing their dosages in a single experiment to identify novel pioneer factors crucial for cellular identity. This approach aims to enhance our understanding of …
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Form Regulation to Address New Construction in Historic Districts
… been as widely used or are relatively new to the regulatory landscape. The tools evaluated in this thesis will be examined through case studies and include a mix of traditional tools and non-traditional tools. The traditional tool case studies are New Orleans, LA, and Savannah, GA. The …
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Explainable Deep Learning Approach for Detecting Money Laundering Transactions in Banking System
… change in technology, fraud patterns and regulatory landscape is making it even harder. To assist the compliance officers with investigation, Artificial Intelligence (AI) based decision support systems are developed which suffers from a high false negative rate of alerts without having …
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Modelling and enhanced scheduling in the cellular vehicular sidelink standards
… new yet disruptive technology enablers in the regulatory landscape. Unfortunately, the relative infancy of the standards has resulted in shortcomings in their ability to effectively handle real-life vehicular service characteristics and network management techniques. Specifically, the scheduler …
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Nature-Based Coastal Adaptation: A Comparative Assessment to Inform Effective Implementation
… over cost and performance, a fragmented regulatory landscape, inconsistent planning tools, and the context dependence of NbS design. This thesis aims to explore these diverse uncertainties in detail by shedding light on the key factors and processes that may pose critical barriers or …
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Foundations for Building an Innovation-Centric Product Development Framework for Medical Devices
The medical device industry, governed by a tight regulatory landscape, often relies heavily on structured Product Development Processes (PDPs) to bring innovative solutions to market. These structured processes create significant challenges when integrating technological innovations that emerge in …
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New Revenue Management and Distribution Technologies in the Airline Industry: Legal, Regulatory, and Commercial Implications
… of NDC. It considers potential legal, regulatory, and commercial barriers to NDC implementation and the implications of NDC adoption. The contributions of this thesis are three-fold. First, the history and development of airline revenue management and distribution are comprehensively …
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Telecommunication technologies development in countries of the former Yugoslavia : history, needs and policy options for the future
… Here I address the relevant legal and regulatory landscape development as well as the entrance of the most important business actors in the telecommunications markets of these countries. The history of the telecommunications sector development is also placed in the context of a broader …
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AI Trust and Technology Optimism in the Workforce: Data-Driven Insights into Regional Variation
… focus is on understanding how the industrial and regulatory landscape in which workers operate, combined with their personal experiences with AI, shapes their AI optimism, with a particular emphasis on the US and Europe. While external market innovation indicators provide limited understanding of …
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Machine Learning Applications in Blockchain for Renewable Energy Systems
… findings with a critique of the South African regulatory landscape, the study culminates in the Deployment Feasibility Framework (DFF). This four-pillared framework offers a comprehensive blueprint for implementing sustainable, community-level energy markets, bridging the gap between …
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Controllable magnetic systems for minimally invasive surgery
… forces using custom magnet designs. Finally, the regulatory landscape for medical devices in key markets is examined and the pathway to market for the proposed devised is laid out.
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UNCOVERING LNCRNA-CHROMATIN INTERACTIONS SHAPING HUMAN MONOCYTE TO MACROPHAGE DIFFERENTIATION
… Using a multi-omics approach, we aim to identify regulatory roles of chromatin-associated lncRNAs in a dynamic model of monocyte to macrophage differentiation, a key process in innate immunity. To achieve this, we generated a comprehensive transcript annotation of the system using a novel approach …
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