Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"regulatory genes"”.
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Regulatory Genes of the Bacteroides Conjugative Transposon, CTnDOT
In order to examine which genes are responsible for excision, I first demonstrated that the excision genes orf2c, orf2d, orf3, and exc are part of an operon (the orf2c operon) and that this operon is regulated at the transcriptional level. I found that RteC is an DNA-binding activator of the orf2c …
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Role of Cell Death Regulatory Genes and Radiation Response in Pancreatic Adenocarcinomas
… ras) are known to lead to the inactivation of genes that are directly involved in these pathways of growth inhibition and apoptosis. Oncogenic activated ras inhibits TGF-P signalling through the down-regulation of RII expression and abrogates apoptotic pathways through down-modulation of PAR-4 …
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Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
… a genome-wide CRISPR/Cas9 screen to evaluate genes that are protective against or cause susceptibility to APAP-induced liver injury. HuH7 human hepatocellular carcinoma cells containing CRISPR/Cas9 gene knockouts were treated with 15mM APAP for 30 minutes to 4 days. A gene expression profile …
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Investigating the role of regulatory genes in heterosis for superior growth and biomass production in Arabidopsis thaliana
… focused on investigating the role of selected regulatory genes given their potentially key involvement in heterosis. In the first part of the project, the most appropriate developmental stage for this heterosis study was determined by metabolite level measurements and growth observations in …
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HORMONE EPIMERS REGULATE ER STRESS AND CORE REGULATORY GENES: NETWORK ANALYSIS WITH APPLICATIONS TO GLIOMA AND CHRONIC PRESSURE ULCERS
… treat T98G Glioblastoma cells. We identified 26 genes oppositely regulated by 17β-AED and 17α-AED to directly affect the cellular life or death decision. Network analysis demonstrated that these 26 genes are essential to regulating three critical Glioblastoma pathways. This report, for the first …
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The Evolution of Gene Expression in The Umbrid Fishes: A Comparison of Phylogenies Based Upon Inferred Differences in Structural and Regulatory Genes (Lactate Dehydrogenase, Duplicate, Controller Nodes, Esocidae, Salmoniformes)
… on differences in 51 protein coding structural genes, established relative divergence times among species of mudminnows (Umbridae) and Esox (Esocidae), within the order Salmoniformes. Both cladistic and phenetic analyses support: (1) a close relationship of Umbra limi and U. pygmaea, (2) a …
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The modification of Anthocyanin biosynthesis in dicotyledonous plants
… legumes, using four different anthocyanin regulatory genes and two promoters. The anthocyanin regulatory genes consisted of a matched pair from maize and a mismatched pair from two dicotyledonous species of plants. In order to accomplish this aim, a series of vectors were made that enabled …
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The modification of Anthocyanin biosynthesis in dicotyledonous plants
… legumes, using four different anthocyanin regulatory genes and two promoters. The anthocyanin regulatory genes consisted of a matched pair from maize and a mismatched pair from two dicotyledonous species of plants. In order to accomplish this aim, a series of vectors were made that enabled …
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Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development
… of tumor differentiation through manipulation of regulatory genes is a relatively unexplored area of cancer therapy, however, it might suggest and additional approach for tumour-specific treatment. Therefore, in view of this idea, the present study hypothesized that neuroblastomas (NBs) and …
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Functional characterization of NAC-domain transcription factors implicated in control of vascular cell differentiation in Arabidopsis and Populus
… analysis, we identified many xylem-associated regulatory genes that may control the differentiation of cells involved in wood formation in Arabidopsis and poplar. Prominent among these are NAC-domain transcription factors (NACs). In addition to their roles as regulators of xylem …
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Nuclear proteomics and transcription factor profiling in Chlamydomonas reinhardtii
… study, we were interested in understanding the regulatory mechanisms underlying photosynthesis-related processes. To achieve this goal different molecular approaches were followed. In order to indentify protein transcriptional regulators we optimized a method for isolation of nuclei and …
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New Pleiotropic Co-Regulators of Gas Vesicle and Secondary Metabolite Production in Serratia sp. ATCC39006
… is a complex process, which is part of a wider regulatory network affecting various phenotypes, including the carbapenem and prodigiosin antibiotics. The present study aimed to identify genes involved in pleiotropic co-regulation of GV production and biosynthesis of the carbapenem and …
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Novel pleiotropic regulators of gas vesicle biogenesis in Serratia
… aim of this research study was to identify novel regulatory inputs to gas vesicle production. Mutants were generated by random transposon mutagenesis followed by extensive screening, then sequencing and bioinformatic identification of the corresponding mutant genes. After screening, 31 mutants and …
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Characterisation of pleiotropic regulators of gas vesicle biogenesis, antibiotic production, motility and virulence in Serratia sp. ATCC 39006
… gvrA-gvrC operon is composed largely of regulatory genes. Other genetic regulators of GV biogenesis have been previously described which include the post-transcriptional regulator RsmA, the ribose operon repressor RbsR, the DeoR-family transcriptional regulator FloR, the sigma factor σ …
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An Analysis of Gene Regulatory Evolution Within the Centrarchids
… The degree of divergence between the regulatory genes of different species was assessed investigating the extent to which morphological and molecular development is altered in hybrid embryos. The degree of gene regulatory divergence between species was compared to the amount of …
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Molecular Studies involving the Rev Protein of Caprine Arthritis Encephalitis Virus and Visna Virus.
… lentivirus family. They encode three structural genes (<em>gag</em>, <em>pol</em>, and <em>env</em>) and two regulatory genes (<em>rev</em> and <em>tat</em>). The Rev protein regulates Gag, Pol and Env expression by transporting their mRNAs to the cytoplasm by binding to the RRE (Rev Response …
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Deciphering the biology of axon stretch-growth
… nerve growth that occurs primarily during embryogenesis. Early axons continue to grow from the end distal to the soma, seeking targets on which to synapse. It is believed that once the axons synapse, stretch-growth takes over and is responsible for the great lengths achieved by nerves of the …
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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
… (UPRmt), validating proliferation specific regulatory genes, and proposing gut barrier function–specific genes as regulators of commensal bacteria density. The results from this project have shown that intestinal stem cells (ISCs) respond systemically in the presence of autonomously induced, …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… in a suppression of extracellular matrix (ECM)-regulatory genes involved in the remodeling of collagen fibrils and an upregulation of secreted immunomodulatory factors. Moreover, matrix stiffness induces the expression of nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) regulons, …
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Activities of Bacteroides Conjugative Transposons: CTnGERM1 and CTnDOT
… contains a Tc resistance gene, tetQ, and two regulatory genes, rteA and rteB, is essential for control of excision and transfer functions. TetQ, a ribosome protection type of Tc resistance protein, actually reduced operon expression, possibly by interacting with ribosomes that are translating …
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