Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"regulatory gene"”.
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Control of The Master Virulence Regulatory Gene Atxa In Bacillus Anthracis
… of the <em>Bacillus anthracis</em> structural genes for the anthrax toxin proteins and biosynthetic operon for capsule are positively regulated by AtxA, a transcription regulator with unique properties. Consistent with the role of <em>atxA</em> in virulence factor expression, a <em>B. …
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Computational development of regulatory gene set networks for systems biology applications
… on the identification of interactions among genes or the identification of a gene set ranking according to differentially expressed gene lists, little is known about interactions between higher order biological systems, a network of gene sets. Several types of gene set network have been …
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The Cloning of a Putative Regulatory Gene and the sol Region from Clostridium beijerinckii
… strain Clostridium beijerinckii NRRL B593, a gene which encodes a putative NtrC-like regulatory protein was cloned and sequenced. The gene codes for a polypeptide of 632 amino acids and has been designated the stc gene. Expression of the stc gene was confirmed by RT-PCR. The co-presence of the …
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Statistical Analysis of Gene Expression Profile: Transcription Network Inference and Sample Classification
The copious information generated from transcriptomes gives us an opportunity to learn biological processes as integrated systems; however, due to numerous sources of variation, high dimensions of data structure, various levels of data quality, and different formats of the inputs, dissecting and …
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Heavy Metal Resistance in the Genus Gluconobacter
… analyzed using PCR and sequencing to establish gene homology with Ralstonia eutropha, the most frequently studied Gram-negative bacterium exhibiting cadmium resistance. Amplification of two genes from the czc operon, known to encode cadmium, cobalt and zinc resistance in Ralstonia, was attempted …
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The role of the BHLH038 transcription factor in the regulation of osmotic and drought stress responses in Arabidopsis thaliana
… a lot about plant responses to abiotic stresses. Genetic, molecular and biochemical studies have been conducted over the years in order to identify key regulators in plant drought response. Many regulators such as Transcription Factors (TFs) have been examined over the years in order to verify …
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The Roles of Wnt5 and the Drl Receptor in the Development of the Drosophila Olfactory System
… in Drosophila. In a gain-of-function genetic screen, we identified wnt5 as a candidate regulatory gene for the antennal lobe development. The overexpression of wnt5 in the ingrowing olfactory neurons induces the formation of ectopic glomeruli in the antennal commissure. Conversely, the …
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The Role of Periplasmic Disulfide Bond Status in the Regulation of the Salmonella SPI1 Type Three Secretion System
… intestinal epithelial cells. The master SPI1 regulatory gene hilA is controlled directly by three AraC-like regulators: HilD, HilC and RtsA. A periplasmic disulfide bond oxidoreductase DsbA is required for SPI1 T3SS function. RtsA directly activates dsbA and deletion of dsbA leads to loss of …
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The modification of Anthocyanin biosynthesis in dicotyledonous plants
… legumes, using four different anthocyanin regulatory genes and two promoters. The anthocyanin regulatory genes consisted of a matched pair from maize and a mismatched pair from two dicotyledonous species of plants. In order to accomplish this aim, a series of vectors were made that enabled …
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The modification of Anthocyanin biosynthesis in dicotyledonous plants
… legumes, using four different anthocyanin regulatory genes and two promoters. The anthocyanin regulatory genes consisted of a matched pair from maize and a mismatched pair from two dicotyledonous species of plants. In order to accomplish this aim, a series of vectors were made that enabled …
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The regulatory roles of PyrR and Crc in pyrimidine metabolism in Pseudomonas aeruginosa
The regulatory gene for pyrimidine biosynthesis has been identified and designated pyrR. The pyrR gene product was purified to homogeneity and found to have a monomeric molecular mass of 19 kDa. The pyrR gene is located directly upstream of the pyrBC' genes in the pyrRBC' operon. Insertional …
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Prelamin A Influences a Program of Gene Expression In Regulation of Cell Cycle Control
… discovered the devastating effects of LA gene (LMNA) mutations, as they have associated hundreds of LMNA mutations to a large group of diseases, called laminopathies, with a broad spectrum of phenotypes, ranging from skeletal, muscular, and neurological defects, to defective lipid storage, …
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Genetic analysis of DMSP metabolism in the marine Roseobacter clade
Genetic, biochemical, bioinformatic and molecular approaches were used to analyse microbial catabolism of dimethylsulfoniopropionate (DMSP), an abundant anti-stress compound made by marine phytoplankton. Members of the Roseobacter clade of marine α-proteobacteria may catabolise DMSP by two …
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DRASTIC - INSIGHTS: manipulating gene expression data for formation of hypotheses for plant signal transduction
… beyond that obtained by the authors’ single genes, or clusters of similar expression patterns by browsing multiple treatments at once, identifying potential regulatory relationships between multiple treatments and genes. DRASTIC-INSIGHTS overcomes the limitations of other plant expression …
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REGULATION OF ALGINATE AND PSL POLYSACCHARIDE EXPRESSOIN IN CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA
… patients suffering from cystic fibrosis (CF), a genetic disorder affecting the patient's ability to clear respiratory infections. The P. aeruginosa strains most often recovered from patients suffering from long-term chronic infections are mucoid, overexpressing the polysaccharide alginate. …
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Role of new virulence mechanisms/factors (type 3 secretion system and TOX-R regulated lipoprotein [TAGA]) in the pathogenesis of the emerging human pathogen Aeromonas hydrophila
… virulence factors that contribute to the pathogenesis of this bacterium. We identified and characterized a type 3 secretion system (T3SS) in A. hydrophila SSU. By marker-exchange mutagenesis of the aopB gene, a crucial gene involved in the formation of the translocon apparatus, the …
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Genetic and Acquired Abnormalities in C3 Glomerulopathy and Primary Immune Complex-Mediated MPGN
… and C3GN (<i>n</i>=77). Data obtained from genetic and biochemical analysis were correlated with histological and clinical parameters. We found that the majority of patients across the three histology groups (from 70 to 85 %) showed low C3 and normal C4. About 18% of patients carried likely …
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Contribution of gene duplications to the evolution of genetic networks
Exploring the forces that drive evolution at the gene network level and investigating underlying principles behind this process are fundamental questions in the context of understanding how evolution shapes transcriptional circuits. In this thesis I present two different explorations along these …
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Elucidating the Biosynthesis of Nucleocidin, a Fluorinated Natural Product Produced by Streptomyces Calvus
… of fluoride. The nucleocidin biosynthetic gene cluster has recently been identified in Streptomyces calvus. This provides an opportunity to elucidate the functions of the encoded enzymes. To determine the minimal set of genes required to synthesize nucleocidin, a strategy was developed to …
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