Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"regulatory divergence"”.
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An Analysis of Gene Regulatory Evolution Within the Centrarchids
Three different studies analyzed the divergence of developmental regulation among centrarchid fishes (Centrarchidae, Perciformes). The degree of divergence between the regulatory genes of different species was assessed investigating the extent to which morphological and molecular development is …
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Evolution of Gene Regulation in Papio Baboons
… play an important role in primate evolution and divergence. In support of this hypothesis, comparative evidence clearly demonstrate that gene expression patterns differ between closely related species and tend to evolve under selective constraint. However, we know little about the evolutionary …
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Developmental and Expression Evolution in C3 and C4 Atriplex and their Hybrids
… to investigate the role of cis- and trans-regulatory effects on gene expression divergence. The majority (~80%) of expression divergence between C3 and C4 species arose from cis-only regulatory divergence, suggesting that numerous independent expression changes across the genome drove C4 …
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The Genomic Basis of Heterosis in High-Yielding Triploid Hybrids of Willow (Salix spp.) Bioenergy Crops
… among triploids, as well as cis- and trans-regulatory divergence. Importantly, nonadditive gene expression correlates with heterosis for biomass yield and growth traits among triploid hybrids. The extensive phenotypes collected will provide a database for future trait mapping and serve as a …
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The Evolution of Drosophila Immunity
… expression are an important contributor to this divergence where gene expression is regulated by both cis-regulatory elements, which affect nearby gene expression levels in an allele-specific fashion, and trans-regulatory elements, which affect gene expression by interacting with linked …
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RNA sequencing for the study of gene expression regulation
… species, identifying and characterising the regulatory mechanisms responsible for these changes is an important goal of molecular biology. For this, I studied the regulatory divergence of liver gene expression and of isoform usage between mouse strains. I demonstrate that gene expression …
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Decoding division: single-cell insights into the transcriptional, proteomic and metabolic regulation of proliferating CD4+ T-cells
… larger-scale dataset profiling naive, memory and regulatory CD4+ T-cell subtypes. Subsequent chapters explore how activation induces division-dependent expression patterns at both the gene and protein level. I examine the overlap between division-dependent genes and known IMD-associated loci, …
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Fragmentation in International Financial Regulation: Rethinking Financial Regulation for a Multipolar World
… environments; for managing fragmentation and divergence. This thesis builds on the work on market fragmentation produced by the FSB, IOSCO, and the IMF to understand how deference and comparability-based approaches can facilitate global coordination and cooperation in financial markets outside …
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Transcriptional divergence during cichlid embryogenesis
… when factors such as phyletic age, sequence divergence, and pleiotropy are considered. The single-cell transcriptomic data provides the first developmental atlas for cichlids, covering four developmental stages: gastrula, somitogenesis, pharyngula, and larval. The single-cell profiles also …
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The evolution of gene regulatory landscapes in mammalian tissues
Gene regulatory landscapes are highly complex and evolutionarily unstable. Understanding how genetic and regulatory variations affect gene expression evolution is paramount to gaining insight into phenotypic divergence across species. Although gene expression programs are broadly maintained during …
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The architecture of the stock market accessibility and operational framework: what can an emerging market economy learn from the ‘international standards’ and the ‘best practice’ models of the US and UK?
… international market standards and increasing regulatory convergence with ‘pioneer’ and liberalised markets are deeply entrenched in the agenda of the majority of the policymakers in the emerging market economies, including the Gulf Cooperation Council (GCC) states. A question arises as to …