Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"regulatory T-cells (Treg)"”.
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T-cell Receptor CDR3 Sequence but Not Recognition Characteristics Distinguish Autoreactive Effector and Foxp3+ Regulatory T-cells
<p>Regulatory T-cells (Treg) play an important role in maintaining immune tolerance to self-antigens and in suppressing excessive immune responses in the host. The source, specificity, and plasticity of the forkhead box transcription factor 3 (Foxp3<sup>+</sup>) Treg and conventional T (Tconv) cell …
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LNCFOXP3 CONTROLS CELL IDENTITY AND FUNCTION OF HUMAN REGULATORY T CELLS
Regulatory T cells (Treg) control immunological responses through suppression of effector cells, playing crucial roles both in physiological and pathological contexts. Treg suppressive activity correlates with the tightly regulated expression and stability of their master transcription factor …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… through modulation of the activity of regulatory T-cells (Treg), a subset of T-cells that suppress the immune system and maintain immune tolerance. In three common PDA cell lines, AsPC-1, PANC-1, and MIA PaCa-2, suppression/inhibition of EPAC1 reduced invasion/migration in transwell …
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The role of tissue-resident immune cells in PanIN to PDAC progression
… Tissue-resident group 2 innate lymphoid cells (ILC2) are emerging as important immune modulators of the cancer microenvironment, although their role in PDAC remains contentious with both pro- and anti-cancer roles having been described. In this thesis, I have characterised the role of …
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The role of T cell Immunoglobulin Mucin domain in Herpes Simplex Virus-induced Behçet’s Disease mouse model
… markers for T helper type (Th)1 and Th2 T cells. TIM-1 plays an important role in the regulation of immune responses and the development of autoimmune diseases. TIM-4 is a natural ligand of TIM-1, and interaction of TIM-1 and TIM-4 is involved in the regulation of Th cell responses and the …
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The Role of Apolipoprotein A-I in the Modulation of Cholesterol and Immune Homeostasis
… macrophage populations. Interestingly, DKO LN T cells, B cells and DCs had increased cholesterol compared to controls. DKO LN T cells had increased expression of activation markers and proliferation of CD4+CD44high T cells was increased. Plasma autoantibodies were also increased. We concluded …
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Investigations into the Biological Roles of the E3 ligase Ariadne 2/TRIAD1
… and increased apoptosis, however haematopoietic cells are capable of differentiating into myeloid and granulocytic progenitors and can fully reconstitute lethally irradiated Rag1-/- recipient mice. These Rag1-/-Arih2-/- chimeras recapitulate the lymphoproliferative disorder observed in the mixed …
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Regulatory T cells and circulating cytokines : novel prognostic markers in squamous cells carcinoma of the head & neck
… the complex interaction between HNSCC and immune cells plays an important part in determining tumour growth and progression.HNSCC patients were found to have an imbalance in Th1/Th2-type cytokines and elevated levels of CD4+CD25high Regulatory T cells (Treg). In this thesis, the circulating levels …
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Doxorubicin and T Helper Lymphocytes: Unexpected Allies Against Cancer
… and include the promotion of immunosuppressive cells such as regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC). MDSC expand in tumor-bearing hosts and play a central role in cancer immune evasion by inhibiting adaptive and innate immunity. Different approaches have been …
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Development Of Regulatory T Cells Capable Of Maintaining Immune Homeostasis
The adaptive immune response, comprised of both T cells and B cells, is essential to control infections and eliminate transformed cancer cells. The success of the adaptive immune system relies on the ability to discriminate self from non-self-antigens. The thymus is the site of selection for T …
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Investigating the role of cellular communication network factor 3 (CCN3) in central nervous system myelination and remyelination
… we reported that regulatory T cells (Treg) are required for efficient myelin regeneration in the mouse CNS. Treg secrete cellular communication network factor 3 (CCN3), a matricellular protein that promotes oligodendrocyte progenitor cell (OPC) differentiation and …
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Evaluation of the microenvironment and immune function in histiocytic sarcoma, a tumour of dendritic cells
… oncology, there has been a growing interest in regulatory T cells (Treg). This population of cells has the ability to down-regulate the immune system, aiding tumour growth and diffusion. In the literature evidence can be found of Treg infiltrating tumours and of elevation of percentages of Treg …
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The Role of TCR Specificity in the Regulation of the Immune Response to Self and Commensal Antigens
… Despite the elimination of many self-reactive T cells in the thymus, some T cells with the ability to recognize self and potentially cause autoimmune disease are present in the periphery. The population of CD4<super>+</super> regulatory T cells: Treg) expressing the transcription factor Foxp3 are …
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Investigating interplay between human regulatory T cells and oligodendrocyte lineage cells
… initially restored by oligodendrocyte progenitor cells (OPCs) that migrate to, and proliferate in the site of injury, differentiate into mature oligodendrocytes (OLs) and generate new myelin sheaths, a process termed remyelination. The signals that influence this process in the central nervous …
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Mechanisms Mediating Asthma Tolerance Induced By Regulatory Dendritic Cells Through CD4+CD25+Foxp3+ T Regulatory Cells
IL-10-treated tolerogenic dendritic cells (DC10) have been used as a powerful tool for the treatment of experimental asthmatic responses. We explored the important role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in the induction of tolerance by DC10 in three levels. We first used the siRNA …
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Regulatory CD4+FOXP3+ T cells in Helicobacter pylori-induced disease
… eradicate the infection due to the presence of regulatory T cells that down-regulate the proper immune response. In this thesis we have further analyzed the suppressive capacity, frequency, location and proliferation of regulatory T cells both locally at the site of infection and systemically in …
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The Development and Function of Memory Regulatory T Cells
<p>Naturally occurring CD4+CD25+Foxp3+ regulatory T cells (TReg) are a cell lineage that develops in the thymus and exits to the periphery, where they represent 5-10% of the peripheral CD4+ T cell population. Phenotypically, they are characterized by the expression of the cell surface markers CD25, …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
… group of diseases arising from the epithelial cells of the thymus. TELs include both benign conditions, such as thymic hyperplasia (TH), and malignant lesions, collectively referred to as thymic epithelial tumors (TETs). According to the 2021 WHO classification, TETs are further subdivided into …
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The Effects of Immunomodulatory Agents On the Development of Experimental Autoimmune Encephalomyelitis
… expansion, and migration of autoreactive T-cells. However, treatments options have been shown to only be effective to 20 - 30% of MS patients and may result in adverse effects. The current study investigates the effects and mechanisms of two alternative methods of treatment that may provide …