Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"regulatory T-cell function"”.
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
… rheumatoid arthritis and multiple sclerosis. Regulatory T cells (Tregs) are a subset of CD4+ T cells that express the lineage-specific transcription factor Foxp3 and exert dominant peripheral tolerance to maintain immune homeostasis. It is therefore important to fully understand the underlying …
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Limiting host-microbiota interactions to control intestinal inflammation
… and production of IgA. However, how Th17 cells contribute to intestinal immunity is still largely unknown. Our current studies indicate that Th17 cells play a critical role in controlling microbial contact with the epithelium. IgA is produced in large quantities and secreted into the …
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The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
… to allergens. Interestingly, the failure by regulatory T cells to maintain tolerance during allergic asthma, suggested to be driven by TH2 inflammatory signals, still remains elusive and anti-TH2 therapies with the potential to effectively reduce airway obstruction and inflammation in …
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Roles for the E3 Ligase Itch in Immune Response Modulation
… inflammation of a mice and to determine which cell type is responsible for the pathology, the Itch gene has been targeted for conditional deletion in mice using the Cre-loxP system. The results presented in this thesis provide the first direct evidence that Itch deficient CD4+ T cells are …
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Transcription factor modulation in T-cells to improve cancer immunotherapy
Adoptive transfer of T-cells expressing chimeric antigen receptors (CAR-T) effectively treats refractory hematologic malignancies in a subset of patients, but can be limited by the inability of ex vivo culture systems to expand T-cells sufficiently for effective dosing while producing highly active …