Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"regulatory T cell"”.
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On Thymic Regulatory T-Cell Ontogeny
<p>Regulatory T (Treg) cells play a pivotal role in maintaining immune homeostasis and preventing autoimmunity. Like most T cells, Treg development occurs primarily in the thymus, where T-cell precursors undergo a series of developmental stages, including double-negative (DN), double-positive (DP), …
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Follicular Regulatory T cell migration and differentiation
… output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells located within germinal centres. Tfr cells were first characterised in detail in 2011 and because of this relatively little is known about the exact role of Tfr cells within the GC, and the …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
Regulatory T cells (Tregs) are a subset of CD4+ T cells with suppressive function and are critical in limiting autoimmunity. Increasing Treg numbers can be beneficial in the treatment of several inflammatory disorders. Here, we investigate the roles played by various factors on the control of Treg …
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Mechanisms of CD4+ Regulatory T Cell Heterogeneity in Health and Disease
Regulatory T (Treg) cells are central to the maintenance of immune homeostasis and their dysfunction underlies the pathology of numerous diseases. Treg cell populations are phenotypically heterogeneous, comprising functionally quiescent resting Treg (rTreg) cells, which upon antigen stimulation, …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… differentiation, and activity of Foxp3+ regulatory T (Treg) cells can be affected by variations in the amount of a cognate antigen (Ag) that is present, the cell types by which it is expressed and/or presented, and whether Ag recognition occurs in an inflammatory environment. Recognition …
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Control of inflammation, helper T cell responses and regulatory T cell function by Bcl6
Regulatory T (Treg) cells represent an important layer of immune-regulation indispensible for curtailing exuberant inflammatory responses and maintaining self-tolerance. Treg cells have translational potential for autoimmunity, inflammation, transplantation and cancer. Therefore, delineating the …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
… rheumatoid arthritis and multiple sclerosis. Regulatory T cells (Tregs) are a subset of CD4+ T cells that express the lineage-specific transcription factor Foxp3 and exert dominant peripheral tolerance to maintain immune homeostasis. It is therefore important to fully understand the underlying …
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The control of Foxp3+ regulatory T cell by interleukin-4 receptor alpha-mediated signaling
T regulatory (Treg) cells play a pivotal role in the maintenance of self-tolerance and immune homeostasis. Forkhead box P3 (Foxp3)+ Treg function is controlled by environmental cues of which cytokine-mediated signaling is a dominant component. Recently, Interleukin (IL)-4 has been shown to play an …
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CHARACTERIZATION OF THE EPIGENOMIC PROFILE SHAPING HUMAN FOXP3+ REGULATORY T CELL IDENTITY IN THE TUMOR MICROENVIRONMENT
… of the anti-tumor immune response. Cancer cells orchestrate several mechanisms to grow unchecked while promoting a suppressive tumor microenvironment (TME). In this context, CD4+ FOXP3+ regulatory T cells (Tregs) have emerged as a major immunosuppressive population sustaining cancer …
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Re-education of myeloid immune cells to reduce regulatory T cell expansion and impede breast cancer progression
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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The Expression Of Connexin-43 By CD11c+ Dendritic Cells Is Required to Maintain CD4+ Foxp3+ Regulatory T Cell Population in Peripheral Lymphoid Organs
<p>Foxp3<sup>+</sup> regulatory T cells (T<sub>R</sub>) are an immunosuppressive subset of CD4<sup>+</sup> T cells that maintain homeostasis of the immune system. They are sustained by the interaction between the Major Histocompatibility Complex (MHC) molecules present on antigen presenting …
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Limiting host-microbiota interactions to control intestinal inflammation
… and production of IgA. However, how Th17 cells contribute to intestinal immunity is still largely unknown. Our current studies indicate that Th17 cells play a critical role in controlling microbial contact with the epithelium. IgA is produced in large quantities and secreted into the …
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The Participation of Transforming Growth Factor Beta in Tumor Immunoevasion
… in the generation of peripheral CD8+CD25 + T regulatory cells. Our findings suggest that in the presence of high concentrations of TGFbeta1, strong costimulatory strength is permissive for the induction of CD8+ T cells possessing suppressor functions. Our studies also demonstrate that the …
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The Role of the PD-1 Immunoreceptor in Pregnancy
… interaction with its ligand, B7-H1, prevents T cell activation. B7-H1 is expressed in the human placenta throughout gestation, therefore we studied the role of the PD-1 receptor in modulating maternal T cells during pregnancy. PD-1 is preferentially expressed on human decidual T cells and B7-H1 …
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Regulation of Murine Mast Cell Homeostasis by TGF-β1 and CD4+CD25+C Regulatory T Cells
Understanding mast cell development is central to allergic disease pathophysiology. Our laboratory has previously shown that cytokines such as IL-4 and IL-10 inhibit mast cell development from bone marrow progenitors. These studies encouraged our interest in other regulatory cytokines, including …
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Smac Mimetic and Combination Immunotherapy for the Treatment of Urothelial Cell Carcinoma
… inhibitors of apoptosis (IAP) proteins regulate cell death signaling cascades. Smac mimetic (SM) compounds are antagonists of these proteins and are being evaluated for their anti-cancer efficacy and immunomodulatory effects. Here, I adopted an orthotopic murine model of urothelial carcinoma …
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Phenotypic and Functional Analysis of Regulatory T Cells during Heligmosomoides polygyrus infection
Helminths are known to stimulate regulatory T cells, which have been shown to downregulate inflammatory as well as allergic conditions such as Crohn’s Disease, Ulcerative Colitis and allergic asthma respectively. However, the differences in the Tregs generated during helminth infection compared to …
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GLP1R IS A T CELL NEGATIVE COSTIMULATORY MOLECULE
… known to be expressed by pancreatic β-cells, gastric mucosa and hypothalamic appetite center. Recently, GLP1R mRNA has been detected on T lymphocytes; however, its function in these cells remains poorly understood. We herein investigated the extent of GLP1R expression in T lymphocytes …
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Effects of Prebiotics on Gut Bacterial Communities and Healing of Induced Colitis in Mice
… The treatment with inulin led to an increase in regulatory T cell number, but this increase was not as significant as the increase induced by the OEI. Inulin increased the inflammation in the mouse colon, whereas inflammation was decreased in the colons of the mice treated with OEI. A three …
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Improving cancer therapy strategies via cellular stress and immune modulation
… on the small molecule ErSO, which induces cell death through hyperactivation of the unfolded protein response (UPR). Preclinical studies in osteosarcoma (OS), chondrosarcoma (CS), and Ewing sarcoma (ES) demonstrated potent ErSO mediated cytotoxicity and anti-metastatic activity, …
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