Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"regulator genes"”.
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Signatures of natural selection and local adaptation in Populus trichocarpa and Populus deltoides along latitudinal clines
… of natural selection on circadian clock-related genes in climatic adaptation, I took a candidate gene approach, selecting circadian clock genes, some of which had been functionally validated, and others hypothesized, to identify signatures of natural selection in Populus trichocarpa and P. …
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Single-cell approaches reveal functional and molecular heterogeneity in malignant haematopoietic stem cells
… reduced expression of specific self-renewal regulator genes, some of which were restored to normal levels in single TET2/JAK2 mutant HSCs. Of these, Bmi1 and, to a lesser extent, Pbx1 and Meis1 overexpression in JAK2-mutant HSCs could improve stem cell self-renewal, allowing development of a …
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Analysis of combinatorial gene regulation with thermodynamic models
Transcriptional control is a key regulatory mechanism for cells to direct their destinies. A large number of transcription factors (TFs) could simultaneously bind to a regulatory sequence. With the constellation of TFs bound, the expression level of a target gene is usually determined by the …
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Entwicklung und Anwendung eines Expressionsklonierungssystems in primären Kardiomyozyten - Identifizierung von Translin als neuem Target der Herzinsuffizienz
… changes in cell shape. In order to identify new regulator genes for sarcomeric rearrangement, we developed an expression cloning system in primary cardiomyocytes. A normalized human heart library was integrated in an inducible adenoviral vector system. After transduction of cardiomyocytes and …
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Integrative approaches for systematic reconstruction of regulatory circuits in mammals
The reconstruction of regulatory networks is one of the most challenging tasks in systems biology. Although some models for inferring regulatory networks can make useful predictions about the wiring and mechanisms of molecular interactions, these approaches are still limited and there is a strong …
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Investigating the Roles of Three Aintegumenta-Like Genes In Maintenance of Arabidopsis Shoot Meristem Activity
… regulated by the combined activities of genetic regulators and plant hormones. We have identified three novel regulators of shoot meristem activity in the model plant Arabidopsis thaliana. These three genes: AINTEGUMENTA (ANT), AINTEGUMENTA-LIKE6 (AIL6) and AINTEGUMENTA-LIKE7 (AIL7) encode …
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In Vitro and In Silico Analysis of Osteoclastogenesis in Response to Inhibition of De-phosphorylation of EIF2alpha by Salubrinal and Guanabenz
… these drugs are able to both promote osteoblastogenesis and reduce osteoclastogenesis. This thesis focused on the role of eukaryotic translation initiation factor 2 alpha (eIF2alpha), which regulates efficiency of translational initiation. The elevation of phosphorylated eIF2alpha was reported to …
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Epidemiologische und molekulare Untersuchungen zur Biofilmbildung in Staphylococcus epidermidis und Staphylococcus aureus
… Varianten mehrere Punktmutationen in den SigB-Regulatorgenen rsbU und rsbW. Dies legt nahe, daß der SigB-Genlokus einer starken genetischen Variabilität unterliegt, die wiederum pleiotrope Effekte auf die Genexpression in S. aureus ausübt. Durch Northern-Blot-Analysen konnte allerdings gezeigt …