Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"regulator gene"”.
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How Neuronal Stem Cells Acquire and Maintain their Identity
… types of progenitors with partially identified regulator gene networks generate the brain. Of interest are Type II NSCs, whose progeny build the central complex, the functional analogue of the vertebrate hippocampus. A previous transcriptome study in the Barros/Bossing lab identified transcripts …
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Genetic regulation of maize floral development - insights from the transcriptome and translatome
… Floral development in plants is regulated by gene expression. Understanding gene expression regulation in maize floral development is critical to regulate floret fertility in other grasses and potentially useful to engineer more productive cereal crops. In this work, I focus on gene expression …
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Use of an Animal Model of Group A Streptococcal Infection to Identify Factors Important for Virulence
… fashion by a complement of transcriptional regulators. A mouse model of streptococcal invasive skin infection was used to identify unknown factors important in GAS virulence. The first section of this study used this model to assess the effect of a mutation in the response regulator gene …
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Novel pleiotropic regulators of gas vesicle biogenesis in Serratia
… solely from proteins expressed from a gene cluster composed of two contiguous operons, gvpA1-gvpY and gvrA-gvrC. Prior to this study, three cognate regulators, GvrA, GvrB, and GvrC, encoded by the right hand operon were known to be essential for gas vesicle synthesis. …
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Identification of novel regulators of the necrosis-inducing protein (Nip) and carbapenem antibiotic production in the phytopathogen Pectobacterium
… can be activated by introduction of its cognate regulator gene, carR, if provided in trans. Pectobacterium is also known to produce a necrosis-inducing protein, Nip, which triggers immunity-associated defence mechanisms. Prior studies identified Hor, RpoS and RsmA as potential regulators of …
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Immunological mechanisms controlling chronic inflammatory diseases
… mediated by self-reactive T and B cells and are generally the results of the breakdown of T cell tolerance to self-antigen and failure of peripheral regulatory mechanisms. In this thesis I studied different mechanisms controlling the development of CIDs. I investigated the initial events involved …
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Study and engineering of nucleic acid-binding repeat proteins
… applications such as genome engineering, gene expression regulation, and imaging of specific nucleic acids. The first part of my dissertation was dedicated to the study and engineering of TALE. Using the published specificity code, a pair of TALE nucleases was engineered to …
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Real-time PCR for diagnosis of botulism and quantification of neurotoxin gene expression in Clostridium botulinum
… (ii) monitoring the expression of the neurotoxin gene, cnt, during different growth phases and under different growth conditions. For the diagnosis of botulism, a real-time PCR-based method including an internal amplification control for C. botulinum types A, B and E was developed. The method was …
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Epigenetic regulation of neuroinflammation in the aged mouse brain
… such as autoimmune disorders, cancer, and neurodegenerative diseases. Therefore, there is a greater need to understand the factors that contribute to quality of life in the elderly. Growing evidence indicates that the immune system plays a critical role in regulating the progression of brain …
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PTEN regulates the BMI1-mediated self-renewal of long-term hematopoietic stem cells in developmental and stress conditions
… drives the transcription of the GFP transgene instead of the self-renewal regulator gene Bmi1, with Pten-deficient mice (Vav-icre+;CD2-C3+;Ptenfl/fl, or vCPΔ/Δ) to generate vCBPΔ/Δ (vCPΔ/Δ;Bmi1GFP/+) mice. The intact GFP signals in vCBPΔ/Δ mice, which represent the expression of Bmi1, …