Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"regulation of metabolism"”.
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Dynamic Regulation of Metabolism in Archaea
<p>The regulation of metabolism is one of the key challenges faced by organisms across all domains of life. Despite fluctuating environments, cells must produce the same metabolic outputs to thrive. Although much is known about the regulation of metabolism in the bacteria and the eukaryotes, …
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Regulation of Metabolism in Mycobacteria and Cyanobacteria
… their cellular processes. The mechanisms of bacterial regulation at the transcriptional level have been investigated by structural and functional characterisation of the transcription factor AmtR from Mycobacterium smegmatis. M. smegmatis is a soil bacteria capable of utilising alternative …
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INTERDEPENDENT REGULATION OF METABOLISM AND INFLAMMATION IN HUMAN MONOCYTES
… serious medical condition which kills millions of people worldwide each year. In the United States, severe sepsis has a mortality rate of 20-30%, with an annual cost of over $25 billion. Modern advances in supportive care have brought the mortality rate down to its current level, however there …
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Epitranscriptomics : translational regulation of metabolism, drug resistance and proteostasis during cellular stress
… -- the naturally occurring system of chemical modifications on ribonucleic acid (RNA) --
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Transcriptional regulation of metabolism and behavior: insights from reconstruction and modeling of complex biochemical networks
… influence the behavior and phenotype of an organism. Yet the mechanism by which a simple genetic change or environmental perturbation alters the state of an organism at the molecular level, and subsequently its phenotype, is still not completely clear. Large-scale omics experiments are …
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Mechanistic insight into the role of dietary fibers and short chain fatty acids in the regulation of metabolism and inflammation in the pig
<p>Dietary fiber is a diverse mixture of polysaccharides exerting multiple functions as it passes through the gastrointestinal tract (GIT). Besides the influence on nutrient digestibility, dietary fiber affects growth performance and host metabolism via modulation of gut microbial community …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… and insulin sensitivity. The association of type 2 diabetes with obesity has been known for quite some time. Understanding the cellular mechanisms of adipocyte function is of great importance in understanding when and why excess adipose tissue becomes dangerous. Signal transduction …
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UNDERSTANDING HEPATIC REV-ERBa INTERACTING PARTNERS AS IT PEAKS AND TROUGHS THROUGH THE CIRCADIAN DAY
In this thesis the reader will find a body of work that describes new and exciting data about the nuclear receptors REV-ERBa and REV-ERBREV-ERBs are interesting proteins to understand because they play important roles in the circadian clock and in the regulation of metabolism on a variety of …
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Computational methods for integrating metabolomics data with metabolic engineering strain design
The genome-scale analysis of cellular metabolites, “metabolomics”, provides data ideal for applications in metabolic engineering. However, many of the computational tools for strain design are built around Flux Balance Analysis (FBA) and were developed using assumptions that preclude direct …
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Loss of TBK1 Kinase Function Improves Disease Outcome in Pancreatic Cancer and Metabolic Syndrome
Aberrant expression and activity of TANK binding kinase 1 (TBK1) has been observed in numerous diseases. Here I've identified novel functions for TBK1 in pancreatic ductal adenocarcinoma (PDA) and in metabolic syndrome that promote disease progression. Activating mutations in KRAS are present in …
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Three-dimensional polymeric capillary network: fabrication and applications
… networks widely exist in nature in forms of mass transport pathways, such as blood vessels. However their complicated geometry and the extra fine small features bring a great challenge to their potential applications in term of fabrication. To overcome the fabrication challenge, we …
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Biochemical and structural characterization of Sirtuins from mammals and Thermotoga maritima
… NAD+ dependent protein deacetylases involved in regulation of metabolism, age related diseases and are suggested to mediate lifespan extending effects of calorie restriction. Mammals contain seven Sirtuin soforms with various cellular localizations and substrate preferences. This work focuses on …
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Evaluation of oxidative enzymes in leaf tissue from intact cotton plants exposed to different oxygen concentrations
Success in evaluating effects of a 75% oxygen atmosphere, containing an ambient concentration of carbon dioxide, on levels of protein and oxidative enzymes in cotton, Gossypium herbaceum L. C.B. 1697, leaf tissue was dependent upon generation of genetically uniform and physiologically similar …
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Biochemical Studies on Uncoupling Proteins and Glucose Metabolism in Skeletal Muscle
… membrane protein that uncouples the production of ATP from the electron transport chain, thereby inducing thermogenesis. Recently, a family of UCP homologues was identified, two of which (UCP-2 and UCP-3) are highly expressed in skeletal muscle. The physiological function of these UCPs is not …
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Characterization of the thioredoxin system in Methanosarcina mazei
… the organisms belonging to the three domains of life. It is one of the major disulfide reducing systems, which provides electrons to several enzymes, such as ribonucleotide reductase, methionine sulfoxide reductase and glutathione peroxidase to name a few. It also plays an important role in …
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The Effect of Staged Diabetes Management on Metabolic Control in Native Americans with Type II Diabetes
<p>Native Americans have a high prevalence of diabetes and diabetes complications (Gohdes, Kaufman, & Valway, 1993). However, there are few published accounts of diabetes intervention studies with Native Americans. The purpose of this study was to examine the effect of Staged Diabetes Management on …
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Systems biology of lung diseases: a multi-perspective view from host and pathogen
"Lung diseases include some of the most widespread and deadly conditions known to affect people around the world. The challenges of clinically tackling lung diseases arise from multiple factors associated with both diagnosis and treatment strategies. In my thesis work, I addressed the challenges of …
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Analysis of the PROM algorithm as a tool to generate genome-scale metabolic-regulatory networks
In this paper, we analyzed the capability of PROM’s algorithm to generate genome--‐scale metabolic--‐regulatory networks, which accurately predict growth phenotypes of transcriptional regulatory mutants under various conditions. E. coli, M. tuberculosis and S. cerevisase were used as model …
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
Collective data gathered from studies of different forms of heart disease indicate a common denominator among them, namely a detrimental change in energy homeostasis. This inference has led to increasing interest in metabolic interventions to treat the diseased myocardium, termed metabolic …