Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"regulation of body weight"”.
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Cooperation between peroxisome proliferator activated receptor alpha and delta in regulation of body weight and hepatic steatosis in mice
… nuclear receptor superfamily. PPARa is a target of lipid-lowering drugs and PPARd promotes fatty acid utilization and is a promising anti-diabetic drug target. However, evidence is growing that PPARd-agonism can stimulate fat accumulation in liver, which may aggravate the toxic situation in …
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Cellular and Molecular Mechanisms Involved in the Induction of the Lipostatic Cytokine Leptin by Tumor Necrosis Factor Alpha
The proper regulation of body weight in humans is remarkably important to our well-being. For instance, obesity is a major health concern since cardiovascular, neoplastic and metabolic diseases occur with much greater frequency in the obese. Conversely, the inappropriate loss of body mass in …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… resistance) is a key factor in the pathogenesis of diabetes mellitus. To investigate therapeutic targets against insulin resistance, this thesis explores the mechanism of action of pharmacological agents and exogenous peptides known or suspected to modify insulin action. These included leptin, a …
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Transcriptional Regulation Of Adipocyte Function
… mass associated with obesity is the result of both hyperplasia and hypertrophy of adipocytes. While adipocyte development and transcriptional processes are well studied in vitro, regulation of in vivo genes (such as leptin), the identity of the adipocyte progenitor cells and the development …
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Growing Up POMC: Pro-opiomelanocortin in the Developing Brain
Neurons in the arcuate nucleus of the hypothalamus (ARH) play a central role in the regulation of body weight and energy homeostasis. ARH neurons directly sense nutrient and hormonal signals of energy availability from the periphery and relay this information to secondary nuclei targets, where …
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Effects of exercise, with and without an associated energy deficit, on postprandial metabolism and appetite regulation
… metabolism in the development and progression of atherosclerosis, and in subsequent years, a number of postprandial metabolic perturbations have been highlighted as potential risk factors for atherosclerotic development. Interventions inducing favourable changes in postprandial metabolism may, …
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Genomic and Physiological Differences for Ghrelin and Leptin Receptor in Lines of Chickens Selected for High and Low Body Weight
… nervous system (ANS) activity is related to body weight regulation. Based on the hypothesis that Most Obesities kNown Are Low In Sympathetic Activity (MONA LISA), it has been suggested that most obese subjects and animals have low sympathetic nervous system activity. Leptin, leptin receptor, …
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Molecular and Physiological Adaptations to Weight Perturbation in Mice
… perspective, obesity may be defined as a degree of relative adiposity sufficient to derange metabolic physiology in a manner that negatively impacts the health of the individual. While population-based cut points based on body mass index (BMI) are frequently used as a means of identifying such …