Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 4620 for “"regulate"”.
-
Understanding How Communication Technologies *Regulate
The third section focuses on how people may individually or collectively influence the values embedded in technologies to promote social goals. This could occur either through market pressure, public pressure, fiscal incentives, or regulation. This section contains a comprehensive analysis of these …
-
Astrocytes down-regulate microglial inflammatory responses
… synthesis such as HO-1 or SOCS. The target regulated by OGD-ACM appeared to be in the nucleus since OGD-ACM did not inhibit phosphorylation and translocation from the cytosol to the nucleus of STAT 1/3 but reduced GAS-promoter activity. Taken together, these results suggest that astrocytes …
-
Insulin -Like Growth Factors Regulate Cardiac Hypertrophy
Interestingly, exogenous IGF-I or IGF-I receptor antibodies also lead to hypertrophy of adult cardiomyocytes. This induction appears to be mediated by the local production of IGF-II, that this growth factor then stimulates the hypertrophy via an IGF-I receptor-independent, IGF-II-responsive pathway …
-
β-Globin Enhancers Regulate Bistable Gene Expression States
Multiple enhancers can coordinately regulate a target gene to ensure robust expression. Under the failure rate model, each redundant enhancer contributes a probability of target gene expression in the cell, and genetic deletion will cause single-cell expression phenotypes. However, this model has …
-
Trim28 Interacts With Ezh2 to Regulate Its Activity
… I discovered that TRIM28 interacts with EZH2 and regulates its activity in breast cancer cells. EZH2, the major H3K27 tri-methyltransferase, is over expressed in multiple subtypes of breast cancer; however, whether EZH2 plays an active role in breast cancer progression or treatment resistance is …
-
Purinergic Signalling and Potassium Homeostasis Regulate Somatosensory Adaptation
… of firing led us to hypothesize that astrocytes regulate somatosensory adaptation through gliotransmitter release and modulation of extracellular K+ To test this hypothesis, we stimulated cortical slices using a ten-pulse adaptation paradigm in layer 4/5 of the somatosensory cortex and recorded …
-
DNA repair proteins Metnase and PARP1 regulate DNA integration
DNA integration occurs naturally in various formats and plays important roles in evolution. DNA integration also affects human and animal health. Various genome-editing tools have been developed based on site-specific DNA integration. In mammalian cells, DNA integration is largely random. The …
-
Murine Cytomegalovirus Encodes Proteins that Regulate Viral Late Transcription
… have homologs in HCMV, and I showed that they regulate late viral gene transcription. During infection, a mutant virus for either M79 or M92 accumulated representative viral immediate early gene products, early gene products, and viral DNA sufficiently but had severe reduction in the …
-
Multiple axes of inter-organ signaling regulate organ scaling
… I report how Activin-β and Myoglianin regulate body size and organ growth respectively. In Chapter one, I review known mechanisms governing growth in Drosophila. In Chapter two, I show that Activin-β signaling via Babo in the muscles is required for muscle growth and proper body size, …
-
Flow-Induced Forces Regulate the Development of Cardiac Valves
… hypothesis is that flow-induced forces directly regulate valve development, however, the mechanisms behind this mechanotransduction remain unclear. The purpose of this study was to i) quantify the flow-induced forces that act on valves during key stages in early development and to ii) test the …
-
Smart Cell-Penetrating Peptides. Strategies to regulate cellular uptake
Contains fulltext : 157591.pdf (Publisher’s version ) (Open Access)
-
Novel Molecules that Regulate Bone Formation and Bone Resorption
… Therefore, understanding the mechanisms which regulate bone formation and bone resorption is important for developing diagnostic and treatment strategies for osteoporosis. In my dissertation, we investigated the role of Glutaredoxin 5 (Grx5), Diabetes and Obesity Related protein (DOR), and …
-
Intrinsic Mechanisms that Regulate T Cell Homeostasis and Function
… gene deletion, TSC1 and DGK, are molecules that regulate signals emanating from the TCR. Additionally, we have demonstrated that both of these molecules negatively regulate the mammalian target of rapamycin (mTOR) in both naïve and activated T cells. mTOR is a critical regulator of cell growth …
-
Mucins regulate virulence and colonization factors in Streptococcus pneumoniae
… environment. First, I identify that mucins downregulate a key virulence factor of S. pneumoniae, the cytolytic toxin pneumolysin (PLY). I show that through the regulation of PLY, mucin protects host cells from toxin-mediated killing and modulates inflammatory signals. Second, I identify that …
-
BioResonant interfaces : tangible, subliminal biofeedback to regulate physiological states
This thesis introduces BioResonant interfaces, which bidirectionally communicate with the user's body to provide information on their physiological state. This facilitates regulation of their stress levels and ultimately a more mindful daily life. Based on the principle of respiratory sinus …
-
Flowering Gene Homologs Regulate Seasonal Growth Changes in Poplar
… the genes and molecular mechanisms that regulate growth and dormancy transitions. Photoperiod and temperature regulate both vegetative and floral phenology. FLOWERING LOCUS T (FT) and FLOWERING LOCUS D (FD) are key regulators of flowering time in Arabidopsis and other plants. The distinct …
-
Investigating Epigenetics as a Mechanism to Regulate Bacterial Heterologous Expression
… found that epigenetic methylation in B. subtilis regulates the metabolome and serves as rationale for continuing the investigation on whether epigenetic methylation can be used to optimize heterologous gene expression.
Page 1 of 231