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Showing 1 to 11 of 11 for “"regioselective synthesis"”.
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Regioselective Synthesis of Cellulose Derivatives
… to develop novel synthetic methods to synthesize regioselectively substituted cellulose derivatives including cellulose ethers and esters, and apply advanced characterization tools to understand structure and its influence on properties, which will give us deep insights into the composition of …
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Regioselective Synthesis of Cellulose Esters
… into functionalized cellulose. However, regioselective substitution of cellulose is extremely challenging, especially in the synthesis of regioselectively functionalized cellulose esters due to the unstable ester bond under aqueous alkaline or acid conditions. In this dissertation, the …
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Regioselective Synthesis of Glycosaminoglycan Analogs
… understandings of GAG biological roles and biosynthesis modulation. Cellulose is an abundant and renewable natural polymer. Applications of cellulose and cellulose derivatives have drawn increasing attention in recent decades. Chemical modification is an efficient method to append new …
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Regioselective synthesis of curdlan derivatives
… reported, but there have been few reports of regioselective functionalization at specific positions of the curdlan backbone, especially of aminated curdlan derivatives which have remarkable potential in biomedical and pharmaceutical applications. We demonstrate herein the design, synthesis and …
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Regioselective Synthesis of Polysaccharide-based Polyelectrolytes
… derivatives from curdlan esters via regioselective ring-opening reactions catalyzed by triphenylphosphine (Ph3P) under mild conditions. Curdlan, a polysaccharide used by the food industry and in biomedical applications, was employed as starting material for preparing these …
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Regioselective Synthesis of Novel Cellulose Derivatives for Drug Delivery
New methods were developed for the regioselective synthesis of new classes of cellulose derivatives with properties that could help improve the delivery of pharmaceutical drugs within the human body. The specific synthetic targets of this research were regioselectively carboxylated and …
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Defined Dimensional Alterations in Enzyme Substrates. Synthesis and Enzymatic Evaluation of Some Lin-Naphthopurines
The development of methodology for the regioselective synthesis of tetra-beta-substituted naphthalenes via a combination of bicyclo{4.2.0}octa-1,3,5-triene and aryl trimethylsilyl chemistry led to the synthesis of benzimidazo{5,6-g}-8H-quinazolin-9-one and …
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Development of transitional metal-catalyzed reactions for organic synthesis
Chapter 1. A general catalyst system for the synthesis of tetra-ortho-substituted biaryls via the Suzuki-Miyaura cross-coupling reaction is described. It was found that the most efficient catalyst system is based on a phenanthrene-substituted biaryl phosphine ligand. Utilizing this ligand, a number …
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HYPERVALENT IODINE-MEDIATED HETEROCYCLIC GROUP TRANSFER REACTIONS TO OXIDATIVE OLEFIN DIFUNCTIONALIZATION
… science, biological processes, and organic synthesis. As synthetic intermediates, these scaffolds can be used as precursors to valuable piperidine derivatives and have recently emerged as important cross coupling handles for metal-catalyzed processes. Unfortunately, current methods to access …
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Synthesis of New Pullulan Derivatives for Drug Delivery
… We demonstrated in this dissertation the regioselective synthesis of a range of 6-carboxypullulan ethers that are promising anionic derivatives for drug delivery applications. These compounds have also shown impressive surfactant properties. Another class of pullulan derivatives was …
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Exploration of the use of Palladium and Nickel to Catalyze Enolate Cross-coupling and the Enantioselective Mizoroki-Heck Reaction.
… variation at the γ-position. We report the regioselective synthesis of mono-γ-arylated 7-methoxy-4-methylcoumarin. We also report efforts towards applying our reaction conditions to other α,β-unsaturated ketones and esters to expand the scope of our reaction conditions. </p> <p>In addition, …