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Showing 1 to 20 of 32 for “"regioisomers"”.
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… and pharmacological action of the additional regioisomers such as EPEA epoxides, 14,15-EEQ-EA, 11,12-EEQ-EA, 8,9-EEQ-EA and DHEA epoxides, 16,17-EDP-EA, 13,14-EDP-EA, 10,11-EDP-EA and 7,8-EDP-EA. Hence, this dissertation reports the bioactive role of omega-3 eCB epoxide regioisomers generated …
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Structure-Property Relationships of Polyester Regioisomers and Pendant Functionalized Polyetherimides
… enabled the synthesis of novel polyester regioisomers and pendant functionalized polyetherimides (PEI)s. Novel monomers incorporated at targeted mol % produced series of polyesters and PEIs, suitable for systematic analysis of key polymer properties. Subsequent compositional, thermal, …
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Synthesis of Novel 6-Substituted and 5-Substituted Pyrrolo[2,3-D] Pyrimidine Antifolates as Targeted Anticancer Therapies
… design variations include: methylated thiophene regioisomers, fluorinated phenyl regioisomers, thionyl regioisomers on the side chain of pyrrolo[2,3-<em>d</em>]pyrimidines. As a part of this study, a series of new compounds have been synthesized and characterized. Of these, ten final compounds …
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Design, synthesis, and characterization of porphyrin derivatives for biological applications
… and cellular studies of novel mono conjugated regioisomers of chlorin e<sub>6</sub> derivatives that are promising photosensitizers for photodynamic therapy. All three regioisomers were synthesized from pheophytin a, which was extracted from the alga Spirulina pacifica. In vitro investigations …
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Experimental and Computational Studies in Bioorganic and Synthetic Organic Chemistry
… reported the asymmetric syntheses of tryptophan regioisomers in which the amino acid side chain is attached at different position of the indole moiety. These new tryptophan regioisomers can effect a different mode of cationâ Ï interaction. In nature, dramatic increases in binding affinity can be …
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Probing regioselectivity in the Diels -Alder cycloadditions between *[60]fullerene and aryl substituted acenes
… discrimination of 5,12 and 6,11 cycloaddition regioisomers of 15 and 41-45, as well as select Diels-Alder cycloaddition regioisomers of 22. The Diels-Alder reactivities of [60]fullerene across various aryl substituted derivatives of 15, compounds 41-45, are also studied. It is observed that …
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Control of mechanochromic reactions in a polymer matrix
… effect is further studied for six NP regioisomers, each with different pulling points on the naphthalene ring. Computational simulations predict that only two regioisomers are mechanochromic. Tensile testing of polymers containing these two regioisomers confirmed mechanochemical …
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Synthesis of Novel Cyclobutane Nucleoside Analogues
… a 6-chloropurinyl anion to generate N-7 and N-9 regioisomers. The stereoselective reduction of the N-alkylated ketones yielded the cis-alcohols quantitatively and the geometric configuration was confirmed by spectroscopic data and X-ray diffraction. Photolysis of N-7 and N-9 coupled ketones was …
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Aspects of the chemistry of 1,4-naphthoquinones. An investigation of nucleophilic substitution reactions of alkylamines and hydroxyalyklamines on 1,4 napthoquinones and the role of solvent on the position of substitution.
… at either the 2- or 3-position. Although both regioisomers were produced in all the reactions, protic polar solvents favoured the formation of the 3-regioisomer, whereas non-protic solvents favoured the formation of the 2-regioisomer. It has also been found that formation of 2,3-diaminoalkyl …
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Designing Functionality into Step-Growth Polymers from Liquid Crystallinity to Additive Manufacturing
… semi-aromatic polyesters using one of 4,4'BB's regioisomers, either 3,4'BB or 3,3'BB, largely resulted in amorphous or semi-crystalline polymers depending on the selection of aliphatic diol. Incorporation of the meta isomer (3,4'BB) into traditionally LC polymers, such as poly(diethylene glycol …
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Studies on the stereo- and regiochemistry of [4+2] cycloaddition of nitroso compounds to chiral halobenzenediols. Total synthesis of lycoricidine
… every case. When ethyl propiolate was used, two regioisomers 7 and 8 were obtained. In contrast, the addition of nitroso dienophiles, derived in situ from the oxidation of hydroxamic acids, to protected halocyclohexadienediols provided chiral bicyclic oxazines of type 9, as single isomers. These …
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The Biochemical Pathway Leading to Lpa Generation Upon Blood Coagulation
… step in LPA production. To prevent acylmigration regioisomers of oleyl‑<em>sn</em>‑glycero‑3‑phosphocholine (LPAF) were synthesized. ATX preferred the <em>sn</em>‑<em>1</em> over the <em>sn</em>‑<em>2</em> regioisomer of LPAF. We propose the following LPA production pathway in blood: 1) Activated …
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SYNTHESIS OF ALL-CARBON SPIROCYCLES BY INTRAMOLECULAR IRON-MEDIATED DIENE/OLEFIN CYCLOCOUPLING
… of this material afforded a 2:1 ratio of regioisomers. Two related complexes, in which the pentenyl side chain is replaced by a butenal or hexenoic ester, respectively, were prepared via the reaction of tricarbonyl(2-methylcyclohexadienyl)iron hexafluorophosphate with the alkylzinc-copper …
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Synthesis and functionalizations of tetrapyrrole derivatives
… route for selective synthesis of benzoporphyrin regioisomers and Chapter 4 mainly discusses new work on the efficient synthesis of the so-called "Hangman Porphyrin" analogs. Chapter 5 consists two parts. The first part is devoted results of work on the total synthesis of an important porphycene …
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Hydroamination of terminal allylic imines, allylic amines, and internal and terminal homoallylic amines: Regioselective and regiodivergent transformations
… complex molecules and often allows access to two regioisomers (Markovnikov and anti-Markovnikov) from one starting material. 1,2-diamines are a common motif in many organic molecules. However, their synthesis often involves a lengthy, multi-step synthetic sequence. We report the Rh- and …
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The Exploration of a Strategy for Regioselective Arene Amination Utilising Non-Covalent Interactions
… associated with these methods, with mixtures of regioisomers commonly obtained in most protocols. Non-covalent interactions have been used in a limited number of examples to control regioselectivity in radical reactions. We therefore decided to investigate whether non covalent interactions …
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Development of new transition metal-catalyzed carbon-fluorine, carbon-nitrogen, and carbon-carbon bond forming processes
… for addressing the problem of the formation of regioisomers in Pd-catalyzed fluorination reactions. Chapter 2. Mechanistic Studies on Pd-Catalyzed Fluorination of Cyclic Vinyl Triflates: Evidence for in situ Ligand Modification by TESC₃ as an additive. A detailed mechanistic hypothesis for the …
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Synthesis of ferrocenyl and 1-methylpyrrolyl bisphophines via electrophilic addition and substitution reactions of tungsten-coordinated phosphenium ions and phosphine triflates
… Reactions of 4 or 5 with N-methylpyrrole led to regioisomers [W(CO)5{PPh2(2-C5H6N)}] (7) and [W(CO)5{PPh2(3-C5H6N)}] (8). Compound 6 reacted with N-methylpyrrole to form regioisomers [W(CO)5{PPhCl(2-C5H6N)}] (9) and [W(CO)5{PPhCl(3-C5H6N)}] (10). Electrophilic substitution of 4, 5, or 6 with the …
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Preparation of azidobrevianamide A and synthetic and biological studies of tetrazomine
The regioisomers 5-azidobrevianamide A and 7-azidobrevianamide A were synthesized from natural (+)-brevianamide A. The synthesis involved nitration, reduction to the amine, formation of the diazonium ion, and reaction with azide ion. These compounds might be of potential use as photo-affinity …
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Developing hydrogen oxidation electrocatalysts using a frustrated Lewis pair approach
… system. Finally, the cyclic voltammetry of two regioisomers of tris[bis(trifluoro-methyl)phenyl]borane was explored for the first time. Solutions of tris[3,5-bis(trifluoromethyl)phenyl]borane in the donor solvent tetrahydrofuran were highly effective for facile hydrogen cleavage. Replacing the …
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