Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"regenerative therapies"”.
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
Stem cell based therapies offer hope for the treatment of retinal disease. In the mammalian retina, Müller glia possess some stem cell-like characteristics. However, their capacity for neurogenesis remains limited. To identify factors influencing the neurogenic potential of Müller glia in vitro, a …
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Towards Mammalian Retinal Regeneration: Cell Signaling in Re-Differentiating Mouse Müller Glia and Transcriptional Regulation of the Axonal Guidance Receptor EPHA5
… retina cannot regenerate. For stem cell therapies to regenerate a functional retina, multiple challenges must be overcome. These include identification of stem cell sources, targeted differentiation into particular retinal neuronal cell types, delivery to the damaged area, survival and …
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Barcoding tools to track development and function of stem cell constructs for biomedicine
… can thus improve the function and persistence of regenerative therapies. Our lab has previously developed in-vitro tools that allow the study of biological development. This work extends on that body by developing two distinct tool sets. Firstly, we develop a scheme for tracing large-scale clonal …
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The Isolation and Differentiation of Adipose Derived Mesenchymal Stem Cells
… life for society’s elderly. Recent advances in regenerative medicine have revealed that an abundant and readily available source of adult mesenchymal stem cells (MSCs), resides within adipose tissue. Previous research has demonstrated that MSCs can differentiate into multiple specialized cell …
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HeartLander Surgical Feasibility and Commercialization
… look toward existing practices and developing regenerative therapies for expanding its customer base.
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… cells are rare and expansion without the loss of regenerative function is required. We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during expansion, generating more ALDHhi cells for therapy. ALDHhi cells expanded for 6 days with …
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3D Printing Of A Biocompatible Scaffold And A Real-Time Imaging Window For Monitoring Rat Spinal Cord Regeneration
The development of effective regenerative therapies for spinal cord injury (SCI) remains limited by two critical challenges: the absence of structurally optimized bridging scaffolds and the inability to monitor biological integration in real time. Conventional experimental approaches rely primarily …
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Engineered hydrogels for tracking cell signaling from the outside-in
An exciting new strategy for regenerative therapies involves the conversion of somatic cells back into an embryonic stem cell (ES)-like state, termed induced pluripotent stem cells (iPS). iPS cells have the same potential for differentiation as ES cells and hold immense promise for tissue …
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Functional Restoration of Irradiated Salivary Glands Through Modulation of aPKCζ and Nuclear Yap in Salivary Progenitors
… quality of life, accentuating the need for regenerative therapies. Stem/progenitor-cell based therapies have been proposed to regenerate the irradiated glands; however, the identity of stem and progenitor cells in the adult salivary glands has remained somewhat elusive. Moreover, it is …
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Quantitative correlations among human mesenchymal stem cell mechanical properties and biological function
… and adipocytes. MSCs offer the means for regenerative therapies not possible with conventional small molecule/antibody/ nucleic acid therapeutics. However, all MSCs are not equivalent. Adult MSCs (aMSCs) derived from infant or adult sources are heterogeneous, exhibit poor overall …
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Bioengineering Microporous Annealed Particle Scaffolds to Recruit Neural Progenitor Stem Cells and Promote Angiogenesis in the Stroke Core
… remains a significant gap in the need for regenerative therapies for stroke compared to what is currently available. An ideal therapy would be one that stimulates the formation of new tissue with the ability to regain any function previously lost due to stroke. Therefore, methods exploiting …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… environment that might be more suitable for regenerative therapies. A scaffold was also used to investigate the delivery of neural progenitor cells one week after injury. After four weeks, viable implanted cells were found to have differentiated into astrocytes, oligodendrocytes, endothelial …
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Gene Delivery to the Blood-Brain Barrier for Ischemic Stroke Therapy
… approaches for the treatment of stroke. Regenerative therapies have been identified as the major need for curing stroke [1]. We explored two different carriers (poly (ethylene glycol)<sub>5k</sub>-poly (L-aspartate-diethylenetriamine)<sub>48</sub> (PEG-DET) / Pluronic P84 (P84) and …
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The role of the P2Y2 nucleotide receptor in salivary gland regeneration
… to enhance the ongoing efforts to develop better regenerative therapies for damaged salivary glands. The P2Y2 nucleotide receptor (P2Y2R), a G protein-coupled receptor equipotently activated by ATP and UTP, is upregulated in a variety of tissues, including salivary gland epithelium, in response to …
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Effects of Keratin Biomaterial Therapeutics on Cellular and Inflammatory Mechanisms in Injury and Disease Models
… made keratins well-suited for the development of regenerative therapies. In particular, keratins have demonstrated bioactivity in both in-vivo and in-vitro studies, by altering immune and stem cell phenotype and function and promoting an anti-inflammatory/wound healing environment. This work seeks …
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Tendon Regeneration: Roles of Growth Factors and Phenotypic Diversity in Tendon Stem Cells
… implications in the current standard-of-care in regenerative therapies for tendon. Our benchtop tenogenesis assay can be used to determine the therapeutic potential of allogeneic MSC lines and MSCs from novel sources for 'off-the-shelf' treatments. Our study of TSCs lends valuable insight to the …
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Thick Conducting Polymer Coatings for Safe Electric Field Delivery to the Spinal Cord
… to maximise independence, as effective regenerative therapies remain unavailable. Electric field-guided stimulation has emerged as a promising approach to promote axonal regeneration after SCI, yet clinical translation has been constrained by the electrochemical and mechanical …
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Homing and Differentiation of Mesenchymal Stem Cells in 3D In Vitro Models
… or injury are major challenges in stem cell therapies. Enhancing stem cell homing could improve their therapeutic effects. Homing is a process that involves cell migration through the vasculature to target organs. This process is defined in leukocyte transendothelial migration (TEM); however, …
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Serum Stable Carbohydrate-Oligoethyleneamine Copolymers for Nucleic Acid Delivery
… have a great promise for stem cell-based and regenerative therapies.
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Silver Nanoparticles As Drug Delivery Systems
… biomaterials. Adult stem cell based regenerative therapies have been one of the most widely researched areas of tissue engineering. This is due to the recent success of in vitro differentiation of stem cells and a high demand to replace damaged organs and tissues from autologous and …
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