Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 60 for “"regenerative capacity"”.
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Effect of Cellular Positional Identity on Bone Regenerative Capacity for Tissue Engineering
The aim of this study was to investigate the stability of positional identity markers and phenotypic differences in isolated osteoblasts from distinct anatomic regions. In addition, the ability of heterotypic co-cultures to reprogramme site-specific Hoxa gene expression also tested. Rat …
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Retinoic Acid Pathway Inhibition to Expand Human Hematopoietic Progenitor Cells with Islet Regenerative Capacity
… cells are rare and expansion without the loss of regenerative function is required. We hypothesized that BMS 493, an inverse retinoic acid receptor agonist, will prevent HSPC differentiation of HSPC during expansion, generating more ALDHhi cells for therapy. ALDHhi cells expanded for 6 days with …
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Exploring metabolic and molecular mechanisms regulating age-related declines in human skeletal muscle regenerative capacity.
… poorly defined. Age-related impairments in the regenerative mechanisms may contribute to the age-related loss of muscle mass and function, which has negative consequences for overall health and disease. Thus, the first aim of this thesis was to initially investigate multiple targeted mechanisms …
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Development of a multi-stage purification process for serum-derived exosomes and evaluation of their regenerative capacity
… biomarkers. Current literature has reported regenerative benefits for blood-derived exosomes but the majority of these studies purified exosomes using ultracentrifugation (UC), a method that has been found to have high levels of protein contamination. Here the regenerative capacity of …
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New insights into cornea-lens regeneration in Xenopus laevis: the role of Wnt/beta-catenin signaling and the regenerative capacity of the limbal region
… the knowledge to attempt to recapitulate these regenerative processes in other species, including our own. Towards this end, the focus of this work is centered on understanding the cell and molecular mechanisms of lens regeneration in the frog, Xenopus laevis, which possesses a high capacity to …
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Heart Regeneration: An Evolutionary Tale
… and teleost fish retain a robust cardiac regenerative capacity throughout their life, a phenomenon that is mediated through the proliferation of pre-existing cardiomyocytes. The adult mammalian heart lacks any meaningful endogenous regenerative response following injury. However, embryonic …
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Development of a bioreactor imaging system for characterizing embryonic stem cell-derived cardiomyocytes
… of mortality in the United States. Because the regenerative capacity of adult tissues such as the heart is limited, human embryonic stem cells (hESC) have emerged as a source for potential cardiac therapies. However, despite the use of a variety of biochemical differentiation protocols, current …
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Proteomic Characterization of Human Multipotent Stromal Cells Secreted Proteins with Therapeutic Potential for β-cell Regeneration
… as an important contributor for islet regenerative capacity. Additionally, we recognized the clinical applicability of determining protein signatures that could be used to screen hMSC that possessed islet regenerative capacity. Therefore, a robust quantitative proteomics method was …
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YAP/TAZ REGULATES ALVEOLAR REGENERATION AND RESOLUTION OF LUNG INFLAMMATION
… from inhaled infectious agents. Therefore, the regenerative capacity of the alveolar epithelium is critical for recovery from these insults to rebuild the epithelial barrier and restore pulmonary functions. Here, we show that sublethal infection of mice with Streptococcus pneumonia, the most …
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Molecular Mechanisms That Govern Human Cardiac Stem Cell Age Disparity
… benefit, however these stem cells lack the regenerative capacity unique to neonatal cardiovascular stem cells. The goal of this work was to identify mechanisms that contribute to the decline of cardiac stem cell regenerative ability with age and investigate novel therapeutic strategies to …
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Stem-Cell Like PDGFR? Cells are Induced in Chronic Intestinal Partial Obstruction
… mechanical injury. This project investigated the regenerative capacity of the gut by injuring the murine gastrointestinal tract and characterizing the changes that occur in several cell populations critical to gastroenterological function. To accomplish this, a chronic partial intestinal …
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Investigating the effects of aging and the neuromodulator retinoic acid on neurite outgrowth in a novel CNS organ culture
… and that individual nerves differ in their regenerative capacity, exhibiting either vulnerability or resilience to age-related decline. Further, I explored the effects of retinoic acid, a vitamin A metabolite that influences neurite outgrowth. Retinoic acid promoted outgrowth in the CNS from …
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Rejuvenation of CNS Progenitors via Partial Reprogramming
… (remyelination), but, like all stem cells, their regenerative capacity declines with age. OPCs progressively fail to differentiate into mature oligodendrocytes following a demyelinating insult with age, and this failure plays a key role in the progression of prominent neurodegenerative and …
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Accounting for Wetlands in Biocapacity: Data Integration, Sensitivity Analysis, and Implications
… accounting frameworks. The Footprint (EF) and Biocapacity (BC) are paired sustainability indicators that together describe the balance between human demand on nature and the biosphere’s regenerative capacity. This thesis integrates wetlands as a distinct category in the Biocapacity framework using …
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Cytokinins tolerance and in vitro selection for dwarfism in apple (Malus x domestica Borkh.)
… 4 weeks of dark incubation increased regenerate capacity of apple cultivars. The optimum levels of sucrose for regeneration were between 20 to 40 grams. Overall, no significant interaction was found between TDZ and dark period and between TDZ and sucrose to affect shoot regeneration. In most of …
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STUDY OF THE EFFECT OF TUMOUR EDUCATED MACROPHAGES ON NEURAL CELLS
… of function, mainly due to the poor intrinsic regenerative capacity of the central nervous system (CNS). At the lesion site, the hostile microenvironment which develops within the CNS prevents regeneration. Current therapeutic strategies for traumatic CNS injury aim at patient stabilization and …
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Peripheral nerve regeneration through collagen devices with different in vivo degradation characteristics
… with a different density of crosslinks, the regenerative capacity of each member of the series of tubes was studied to determine the effects of device permeability, crosslink density, and in vivo tube degradation rate on peripheral nerve regeneration. It was first observed that the device …
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
… aimed at increasing MPC proliferation and the regenerative capacity of aged skeletal muscle.
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Effectiveness of autogenous tooth bone used as a graft material for regeneration of bone in minipig
… experimental group and the control, with more regenerative capacity in the experimental group. Mean percentage area for new bone were 43.74±11.96 % and 30.79±2.93 % for experimental and control groups, respectively. CONCLUSION: We hereby report that autogenous tooth bone is a good alternative …
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A microculture approach towards enhanced productivity and genetic improvement of pecan (Carya illinoensis)
… explanting media. This enabled study of the regenerative capacity of the mature pecan embryo explants, and the factors affecting shoot multiplication and rooting. A simple procedure was adapted for the measurement and comparison of water availability in the explanting media. Disinfestation of …
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