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Showing 1 to 18 of 18 for “"reductive coupling"”.
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Reductive Coupling and Polymerization of Unsaturated Amides
Made available in DSpace on 2015-05-12T17:02:30Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 0006973.PDF: 4366142 bytes, checksum: fd7cc08076490683166d6124a813a4a8 (MD5) Previous issue date: 1953
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Reductive coupling and related reactions with Mo and Ti tris- anilides
… to mechanistic studies of the classical Pinacol coupling.
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Novel reactions of a neutral organic reductant : reductive coupling and nanoparticle synthesis
… as a potential source of new chemistries for reductive coupling and the synthesis of group IV nanoparticles. This super electron donor was used as a co-reductant for nickel-catalyzed reductive coupling of aryl halides in order for the reaction to be homogeneous and avoid the traditional …
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Applications of titanium-mediated reductive coupling and cyclocarbonylation reactions toward natural product synthesis
… not only a synthetic value of tandem reductive cyclization - carbonylation reactions in the preparation of complex molecules but also the interesting stereoselectivity observed therein. The first part of this work employs the titanium-mediated cyclocarbonylation of tethered dienals for …
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Reductive coupling, and, transition metal calixarene complexes : metal-metal quadruple bonds and pockets
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1995.
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Nickel-catalyzed reductive coupling reactions of 1,6-enynes and the total synthesis of (+)-acutiphycin
Nickel-Catalyzed Reductive Coupling Reactions of Aldehydes and Chiral 1,6-Enynes. A study of nickel-catalyzed reductive coupling reactions of aldehydes and chiral 1,6-enynes has provided evidence for stereospecific ligand substitution from a planar three-coordinate nickel species as a plausible …
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Nickel-catalyzed reductive coupling reactions : application to the total syntheses of pumiliotoxins 209F and 251D
Catalytic Asymmetric Reductive Coupling of 1,3-Enynes and Aromatic Aldehydes Nickel-catalyzed reductive coupling reactions of 1,3-enynes and aromatic aldehydes efficiently afford conjugated dienols in excellent regioselectivity and modest enantioselectivity. These reactions were conducted in the …
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Diastereoselective nickel-catalyzed reductive coupling of alkynes and aldehydes and application towards the B-type amphidinolides
… developed stereoselective nickel-catalyzed reductive coupling reactions of alkynes and aldehydes to the synthesis of complex natural product targets was explored. The "B-Type" amphidinolides were selected as ideal targets owing to their molecular complexity and the paucity of synthetically …
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Enantioselective nickel-catalyzed reductive coupling reactions of alkynes and aldehydes. Synthesis of amphidinolides T1 and T4 via catalytic, stereoselective macrocyclizations
I. Enantioselective Nickel-Catalyzed Reductive Couplings of Alkynes and Aldehydes Allylic alcohol synthesis via a nickel-catalyzed reductive coupling reaction of alkylsubstituted alkynes and aldehydes was studied for ligand effects with respect to the regioselectivity and enantioselectivity of the …
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Selective, nickel-catalyzed carbon-carbon bond-forming reactions of alkynes
… enantioselective method for the nickel-catalyzed reductive coupling of alkynes and aldehydes has been realized using the commercially available (+)- neomenthyldiphenylphosphine as a chiral ligand. Allylic alcohols are afforded with complete (E/Z)-selectivity, generally >95:5 regioselectivity, and …
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Photochemical Methods for the Construction of C-C and C-X Bonds
… of a photoredox-catalysed dehydrogenative cross-coupling reaction between aldehydes and alkylarenes in continuous flow. In the process, the reaction was adapted to a flow set-up, further optimised and expanded to prepare a range of α-aryl ketones including drug derivatives. Furthermore, the …
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Enantioselective synthesis of 2,2,5-Tri- and 2,2,5,5-tetrasubstituted tetrahydrofurans and synthesis of diketopiperazine containing natural products
… sequence, followed by a Lewis acid promoted coupling with indole giving the key quaternary oxindole intermediate. A new protocol for intramolecular reductive coupling of the oxoindole and bis-unsaturated diketopiperazine led to successful construction of the hexacyclic skeleton.
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Nickel-catalyzed intermolecular reductive couplings of alkynes and aldehydes ; Enantioselective synthesis of (-)-terpestacin and structural revision of siccanol using catalytic stereoselective fragment couplings and macrocyclizations
I. Nickel-Catalyzed Intermolecular Reductive Coupling of Alkynes and Aldehydes. Alkynes and aldehydes were coupled reductively in a single catalytic reaction to yield di- and trisubstituted allylic alcohols with high stereoselectivity and regioselectivity. In most cases, a 1:1 ratio of alkyne to …
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A scalable protocol for the synthesis and use of neomenthyldiphenylphosphine.
… ligand was then utilized in the nickel-catalyzed reductive coupling of alkyne 3 and aldehyde 4 to afford allylic alcohol 5 in high yield and enantiomeric excess. Several important modifications were made to the initially communicated procedure in order to effectively translate this methodology …
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Molecular design of conjugated polymers for the control of conformation, electronics and self-assembly
… 1,2-diazines is reported. Palladium-catalyzed reductive coupling methods were developed to allow for the preparation of large quantities of iptycene-derived bipyridazines and biphthalazines, and the controlled synthesis of well-defined oligomers up to sexipyridazine. Crystallographic, …
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Synthesis of Metal-Organic Frameworks and Crystalline Porous Polymers and Studies of Their Reactivity
… demonstrated through study of Cu(I)-mediated NO reductive coupling, a reaction of importance to biological systems and automobile emission abatement. A previously hypothesized but unseen N₂O₂•– intermediate was fully characterized by a range of spectroscopic techniques. In Chapter 4, …
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Asymmetrische Pinakolkupplungen
… two different strategies for asymmetric pinacol couplings. One is to take enantiopure carbonyl compounds as starting materials and the other to introduce chirality using chiral coupling reagents. In this Ph. D. thesis both strategies were investigated. Using the SAMP / RAMP hydrazone method …
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Towards Sacrificial Anode-Free Alkyne Electrocarboxylation
… This work explores the sacrificial anode-free reductive coupling of phenylacetylene and CO₂ to afford cinnamic acid. Previous literature has shown that the addition of Mg salts as a Mg²⁺ source enabled a scalable sacrificial anode-free alkyl halide electrocarboxylation process. In contrast, …