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Showing 1 to 1 of 1 for “"reduced amides"”.
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Pin1 Inhibitors: Towards Understanding the Enzymatic Mechanism
… classes of compounds: ketoamide, ketone, and reduced amide analogues. Specifically, a convergent synthesis of α-ketoamide inhibitors of Pin1 was developed. An α-hydroxyorthothioester derivative of Ser was reacted directly with an aminyl synthon. The reaction was catalyzed by HgO and HgCl2 to …