Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"redox-signalling"”.
-
Genetic screens of RNA binding proteins identify a role for N6-methyladenosine in promoting B cell differentiation
… these reagents to identify roles for RBPs in redox signalling, B cell lymphomagenesis, CD8 T cell activation, and B cell terminal differentiation. These identified over a dozen potential avenues of future investigation into the roles of RBPs in lymphocytes. I chose to further investigate the …
-
Disruption of mitochondrial redox homeostasis as a cellular signal.
… components of eukaryotic cells and exchange signalling molecules, metabolites, proteins and lipids with the rest of the cell. The organelle is key for energy metabolism as they provide most of the cellular ATP through oxidative phosphorylation and regulate intermediate metabolism. …
-
Investigating the role of NADPH oxidase 4 (NOX4) in differentiation and function of induced pluripotent stem cell–derived endothelial cells
… investigated the role of NADPH oxidase-dependent redox signalling in differentiation of mouse and human iPS-ECs, and provide evidence implicating ROS derived from the NOX4 isoform during the differentiation process, which is likely to be important when considering their therapeutic potential. Our …
-
Investigations into novel signalling pathways in the response to viral and bacterial infections
… to viral and bacterial perturbation of host signalling pathways. The TIR-domain containing adaptor TRAM is a relatively understudied protein with regard to TLR signalling, particularly with respect to type-I inferferon production. A re-evaluation of the role of TRAM in TLR7 signalling showed …
-
The Effect of Allopurinol on Left Ventricular Mass in Patients with Treated Essential Hypertension
… morbidity and mortality. Increased activation of redox signalling by oxidative stress (OS) leads to myocyte hypertrophy and fibrosis and is a major non-haemodynamic contributor to LVH. Allopurinol can act as a potent anti-oxidant by inhibiting xanthine oxidase generated reactive oxygen species and …
-
How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling
… AMPK activity, ATP/ADP ratios and cellular redox state in a cell model. I then compounded this with selective mitochondria generated ROS by the mitochondria-targeted redox-cycler, MitoParaquat (MPQ). AMPK activity appeared to correlate with decreasing cell ATP/ADP ratios, indicating that …
-
Regulation of the stomatal response to red light
… One current hypothesis is that the redox state of the chloroplast plastoquinone (PQ) pool could coordinate the Ci-independent response to red light. However, the exact site of perception, and the mechanisms and cell types through which the red light stimulus is communicated remain …