Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"redox-signaling"”.
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NEW METHODS FOR DETECTING BIOMARKERS OF OXIDATIVE STRESS AND REDOX SIGNALING ON PROTEIN CYSTEINE RESIDUES
… species), participate in a variety of cellular redox processes and have become well recognized as messengers in cellular signal transduction. One important mechanism by which cellular redox-based signaling occurs is reversible oxidation of cysteine residues in the presence of low concentrations …
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ROS and SIK regulation of Stress-Induced Sleep
… in the context of sleep, gives an overview of redox signaling in sleep behavior and ends in describing why C. elegans is well suited for answering my research questions. In Chapter 2, I show that KIN-29/SIK modulates mitochondrial redox signaling to regulate stress induced sleep. In Chapter 3, …
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CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING
… of caveolae in ROS/RNS generation and downstream signaling roles in activating endothelial cells are not well known. Hypothesis: Caveolae act as, a) micro-environments in providing spatio-temporal reaction compartments for ROS/RNS generation, tyrosine nitration of proteins, b) platforms to …
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AN INVESTIGATION OF THE REDOX REGULATION OF THE DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE SAMHD1 AND ITS ROLE IN NUCLEOTIDE HOMEOSTASIS
… an alternative mechanism of regulation. A major signaling pathway that has not been investigated with regards to SAMHD1 regulation is redox biology. Redox biology is emerging as a central regulator in myriad cellular processes including cell cycle progression, cellular metabolism, and cell …
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REDOX HOMEOSTASIS IN THE DROSOPHILA TESTIS STEM CELL SELF-RENEWAL AND MAINTENANCE
Reactive oxygen species (ROS) act as important signaling molecules required for fundamental biological processes such as stem cell maintenance. However, aberrant ROS levels lead to oxidative stress, which is highly associated with various human diseases such as cancer and aging. Here, I examined …
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the impact of Ape/Ref1 on hypoxia regulated genes; potential applications for cancer
… is therefore critical. Reduction¿oxidation (redox) signaling systems are emerging as important targets in pancreatic cancer. AP endonuclease1/Redox effector factor 1 (APE1/Ref-1) is upregulated in human pancreatic cancer cells and modulation of its redox activity blocks the proliferation and …
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EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES
… regulators of energy metabolism, apoptosis, and redox signaling, and their genome (mtDNA) is particularly vulnerable to genomic alterations due to its proximity to the respiratory chain, lack of protective histones, and limited repair capacity. Although mtDNA mutations have been implicated in …
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The effects of elevated mitochondrial hydrogen peroxide in S. cerevisiae : a physiological role for cytochrome c peroxidase
… The creation of a yeast strain deficient in thioredoxin peroxidase (x tsa1 ), and its possible involvement in redox signaling, is also discussed.
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
… insults, and this coincided with preserved thiol redox homeostasis and greater stability in mitochondrial bioenergetics. The maintenance of mitochondria thiol was demonstrated through preservation of glutathione, which is a key redox control point in cardiac bioenergetics. When the thiol pool …
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The utilization of boron-rich clusters as aids to detect reactive oxygen and nitrogen species through non-fluorescent modalities
… compounds that play important roles in redox signaling processes to maintain cellular homeostasis. Typically, these finnicky species are detected through activity-based sensors (ABS) which produce a fluorescent response after being selectively uncaged by the target analyte. However, …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… glutathionylation in Ca2+ homeostasis and Ca2+ signaling processes is not well understood. Diamide, a membrane-permeable oxidizing reagent, rapidly and reversibly converts glutathione (GSH) to its disulfide (GSSG), and promotes glutathionylation. In the present Dissertation, the acute effect of …
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Biogenesis and Redox Transition of Iron-sulfur Clusters in Proteins
… in proteins range from electron transfer to redox signaling. The assembly of iron-sulfur clusters in cells requires a complex protein system and acquisition of sulfur and iron. While the sulfur source for iron-sulfur cluster assembly is well-established, the iron source remains elusive. The …
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
… as subsequent calcium influx and its downstream signaling on synaptic AMPAR localization. However, how subcellular compartments, such as mitochondria, contribute to localized signaling, and how they affect AMPAR transport and delivery dynamics are still unknown. Previous work from our lab using …
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Regulation of the chloroplast light harvesting antenna by plastoquinone redox: Modulation of chlorophyll metabolism and thylakoid complex organization
… Such tailoring is achieved by monitoring the redox status of the plastoquionone pool, which serves as an indicator of photosynthetic electron transport. The work in this dissertation seeks to produce a better mechanistic understanding of how light intensity, as sensed by the redox state of the …
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Elucidation of the Various Mechanisms of Antioxidant Activity of Organosulfur Compounds
… essential to life, from protein folding to redox signaling. However, kinetic and mechanistic characterization of their subsequent reactions had not been reported due to the instability of the sulfenic acid intermediate under study. Gratifyingly, as reported in Chapter 5, using our triptycene …
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Redox manipulation alters hippocampal neuron response to semaphorin 3A
… known as semaphorin 3a (Sema3A) and various redox reactions such as the oxidizing function of Mical proteins on f-actin that function downstream of Sema3A. However, what is less understood is how various redox conditions alter these guiding cues. This work investigates the subcellular redox …
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Investigating The Roles of Lung Epithelial Stat3 In Therapeutically Inducible Resistance to Acute Bacterial Pneumonia.
… Pam2ODN-mediated protection requires key signaling components of the TLR pathway and generation of multisource reactive oxygen species (ROS). However, a complete understanding of this unique synergistic protection offered by Pam2ODN is lacking. To investigate the mechanisms underlying …
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Impact of an Acute Bout of Low- and High-Frequency Neuromuscular Electrical Stimulation on Voluntary Muscle Fatigue and Antioxidant Response
Neuromuscular electrical stimulation (NMES) is an intervention used for promoting skeletal muscle contraction, strength, and hypertrophy, particularly in populations with limited voluntary exercise capacity. Stimulation frequency is a key NMES parameter that may influence force production, fatigue …
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Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
… is vulnerable to changes in proteostatic and redox balance caused by temperature, pH, oxidants and xenobiotics. Cysteine-containing proteins are especially at risk as the thiol side chain is subject to oxidation, adduction and chelation by thiol-reactive compounds. All of these thiol-modifiers …