Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"redox stress"”.
-
the impact of Ape/Ref1 on hypoxia regulated genes; potential applications for cancer
… is therefore critical. Reduction¿oxidation (redox) signaling systems are emerging as important targets in pancreatic cancer. AP endonuclease1/Redox effector factor 1 (APE1/Ref-1) is upregulated in human pancreatic cancer cells and modulation of its redox activity blocks the proliferation and …
-
Synthetic Materials with Redox-Triggers for Imaging and Drug Delivery
… stimuli-sensitive materials with two different redox switches including trimethyl-locked quinone propionic acid and nitrobenzyl moieties. Novel redox-sensitive polymeric nanoparticles and micelles were prepared from a synthesized monomer containing trimethyl-locked quinone propionic acid as a …
-
Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
A common mechanism by which redox stress may activate inflammatory responses to potentially initiate, propagate and maintain many diseases states has not been characterized. Accumulating evidence suggests that pattern recognition receptors of the innate immune system such as the toll-like receptors …
-
Impaired tissue responsiveness to B-type natriuretic peptide in heart failure: biochemical bases.
… of Tako-tsubo cardiomyopathy (TTC), a form of “stress-induced” cardiomyopathy and another condition associated with increased BNP release. The study utilized the technique of electron paramagnetic resonance spectroscopy to quantitate the extent of O₂⁻ generation from isolated neutrophils. In …
-
Modeling And Identification Of Differentially Regulated Genes Using Transcriptomics And Proteomics Data
… organisms under reduction-oxidation: redox) stress conditions, circadian and diurnal rhythms of cyanobacteria and the effect of incident light patterns on these rhythms, and the coordination between biological processes in cyanobacteria under various growth conditions. Under redox …
-
Natural history and pathogenesis of Takotsubo cardiomyopathy
… of peroxynitrite (ONOO⁻) anion with associated redox stress, protein nitration and downstream activation of thioredoxin interacting protein (TXNIP). Evaluation of presence of nitrosative stress was performed in a rat model of TTC in parallel with human experiments looking at the local and …
-
CHCHD2 and the tumor microenvironment in glioblastoma
… mitochondria to sense intracellular metabolic stress imposed by the extracellular tumor microenvironment and respond appropriately by relaying their status to the nucleus, thus inducing changes in gene expression and facilitating cellular adaptation. The focus of this work is on the …
-
Defining the Cellular and Molecular Basis of Spondyloepiphyseal dysplasia tarda
… COPII inner coat, take part in the integrated stress response (IRS). Upon perturbations that change cellular homeostasis such as heat shock, redox stress or unfolded protein accumulation, cells activate signalling pathways that result in translation inhibition by sequestering free mRNAs and …
-
Revealing the role of Gα13 in germinal centre lymphomas
… Follow-up studies using Seahorse and cellular stress analysis have shown how *GNA13* loss induces a metabolic switch resulting in reduced mitochondrial respiration and in turn, a reduction in redox stress. These data have revealed completely new and unexpected functions for *GNA13* that might …
-
Exploring the Plasmodium falciparum Transcriptome Using Hypergeometric Analysis of Time Series (HATS)
… lines, we found an increased abundance of redox metabolites and the transcripts involved in redox regulation, and significant reduction in transcription and altered expression of transcripts encoding for core histone proteins. These alterations could help confer an increased tolerance to …
-
Mechanisms by which natural polyphenols regulate the expression of cytoprotective genes
… may be caused by toxicants and oxidative stress either from the environment or from endogenous sources. Therefore, to prevent such damage, multiple mechanisms are deployed by cells to combat the toxic insult and reduce oxidative stress. The CNC-bZIP transcription factor, Nrf2, is known to …
-
Hormetic dietary phytochemicals from Western Canadian plants: Identification, characterization and mechanistic insights
Activation of mammalian stress responsive pathways by plant secondary metabolites may contribute to the protection against certain chronic diseases afforded by fruit and vegetable consumption. This work focuses on the identification of plant compounds that activate the stress-responsive enzyme …