Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"redox balance"”.
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Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
… is vulnerable to changes in proteostatic and redox balance caused by temperature, pH, oxidants and xenobiotics. Cysteine-containing proteins are especially at risk as the thiol side chain is subject to oxidation, adduction and chelation by thiol-reactive compounds. All of these thiol-modifiers …
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Human telomerase reverse transcriptase (hTERT) overexpression modulates intracellular redox balance and protects cancer cells from apoptotic cell death
… well as efficient recovery of the oxidized peroxiredoxin to its non-oxidized form. Our data also provide evidence for mitochondrial localization of hTERT, and a significantly higher activity of cytochrome c oxidase, the rate-limiting enzyme in the mitochondrial electron transport chain, in hTERT …
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Investigation into the destructive and adaptive responses of neural cells to stress
… of homeostasis, particularly of Ca2+ levels, of redox balance and of ATP, contribute to neuronal loss and dysfunction in many neurodegenerative and neurological disorders. This thesis is centred on better understanding the vulnerability of neurons to stress, as well as adaptive responses to these …
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The antioxidant activity of Bulgarian medicinal plants // Проучване на антиоксидантната активност на български лечебни растения
… from Agrimonia eupatoria on markers of the redox balance in serum and tissue homogenates was studied in experimental animals. The effect of Agrimonia eupatoria extract on redox sensitive genes expression in nonstimulated and oxidatively stimulated cell cultures was studied, as well as in …
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Isolation of low ethanol producing yeast strains using adaptive evolution
… limits ethanol production, it also compromises redox balance by preventing the fermentative oxidation of NADH. To compensate for this, the cell regenerates NAD by producing increased amounts of glycerol; glycerol production is an NADH-driven reductive process. It was demonstrated in this thesis …
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Optimising the Wider Energy Metabolome of Microbes Using Targeted UHPLC-MS/MS Present in Bio-Electrochemical Systems for Carbon Dioxide Conversion to Platform Chemicals
… key intracellular energy metabolites that govern redox balance, energy charge, and carbon flux in industrial microorganisms. The method was designed to improve and optimise quenching, extraction, and analysis of yeast and bacterial cultures, enabling robust measurement of NAD+, NADH, NADP+, NADPH, …
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ROLE OF CELLULAR STRESS RESPONSES IN THE PATHOPHYSIOLOGY AND TREATMENT OF PSYCHIATRIC DISORDERS
… reported alterations of neuroinflammation and redox balance following stress-exposure. These mechanisms are part or consequences of cellular stress responses, namely processes that are activated when an insult disrupts homeostasis to promote either survival or death. However, the precise …
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Studies on the anti-cancer potential of sesquiterpene lactone parthenolide
… that parthenolide disrupts intracellular redox balance, induces apoptosis in cancer cells and sensitizes cancer cells to TNFI?-mediated cell death. Furthermore, parthenolide also suppresses the tumor growth in vivo. All these new findings provide a new insight of the parthenolidea??s …
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Effects Of Altering The Peroxisomal Redox State In Models Of Degenerative Disease
… are important regulators of cellular redox balance and function as a signaling platform to regulate anti-aging metabolic and communication networks. In addition the organelle has emerged as a major player in maintaining cellular ROS at an optimal level. At such levels, these ROS are …
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Upregulation of heme oxygenase-1 and activation of Nrf2 by the phytochemicals in protandim
… proposed as a potential mechanism for promoting redox balance. Protandim is a well-defined combination of five widely studied medicinal plants derived from botanical sources [Bacopa monniera, Silybum marianum (milk thistle), Withania somnifera (Ashwagandha), Camellia sinensis (green tea), and …
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An Assessment of the Relationship among Oxidative Stress, Adaptive Immunity and Genetic Variations in the Chicken, Gallus gallus
… the impact of bird genetic variation on redox balance remains to be elucidated. Thus, the central hypothesis of this dissertation is: The bird's adaptive immunocompetence is impacted by their OS level, which is not only influenced by environmental factors, but also related to genetic …
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Transcriptomic and proteomic analysis of lycopene-overproducing Escherichia coli strains
… and gadE); the glyoxylate pathway (iclR); NADPH redox balance (pntB); growth rate reduction; and membrane composition. In the pre-engineered background strain, deleting pntB (~20-25%) and ydeO (~30%) each led to moderately increased production; overexpressing wrbA led to 50-100% more production …
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Assessment of redox markers in cattle
Metabolic redox status may have important implications to cattle health and production. Antioxidants and biomarkers of oxidative stress were evaluated in cattle under three phases of management. Each phase stood alone as a treatment model, and managerial aspects during the phase were evaluated as …
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Investigating systemic effects of chronic stress on hepatic and cardiac tissue in female Wistar rats
… (n=8) or control conditions (n=8) were analysed. Redox balance was assessed via antioxidant assays (superoxide dismutase [SOD], catalase, and ORAC) and oxidative damage marker (malondialdehyde adducts) in whole-cell lysates and subcellular fractions. Autophagy-related proteins (p62, LC3B, …
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Regulation and roles of nutrient-dependent mitochondrial fusion
… and fission and interestingly, this dynamic balance is critical for maintaining organelle function and cellular homeostasis. Studies have shown that mitochondria undergo fusion during amino acid starvation-induced autophagy. This mitochondrial response has been proposed to be regulated by …
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Mitochondrial Dynamics Imbalance as a Potential Driver of Neuronal Decline in the Aging Nervous System of Lymnaea stagnalis
… respiration, mitochondrial fission–fusion balance, and metabolic regulation contribute to functional decline in the central nervous system. Using the pond snail Lymnaea stagnalis as an invertebrate model of neuronal aging, the general hypothesis that disruption of mitochondrial …
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Early onset of age related hearing loss in LDHB knock out mouse
… Mitochondria are key of energy supply, cellular redox balance, signaling and regulation of intrinsic apoptosis in inner ear, especially in the high en ergy demanding cells, such as hair cells and neuron cells (Hengchao, Chen et al., 2014). Lactate dehydrogenates B is important enzyme in …
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Carbon and electron flow via methanogenesis, So₄²⁻, NO₃⁻ and Fe³⁺ reduction in the anoxic hypolimnia of upper Mystic Lake
… reactions were also calculated to obtain a mass balance within the hypolimnia of UML. From the calculations, the approximate organic carbon decomposition rate, measured as CO₂ accumulation, was 7.54 mmol m⁻² d⁻¹. The amount of decomposition from the reactions involving nitrate, sulfate, iron and …
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TARGETING TYPE-I PRMTS RESTORES PLATINUM SENSITIVITY IN OVARIAN CARCINOMA THROUGH MITOCHONDRIAL METABOLISM
… supporting enhanced glutathione-mediated redox buffering. MS023 disrupts these adaptations, depleting glutathione pools and precursor amino acids, reducing redox balance, and shifting central carbon metabolism. Isotope tracing confirms that A2780R cells channel serine-derived carbons into …
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HSP70 as a Target for Correction of Wilson Disease Causing ATP7B Mutants
… processes. However, Cu overload compromises the redox balance in cells and tissues causing serious toxicity. Removal of excess Cu from the body is driven be Cu-transporting ATPase ATP7B, which sequesters the potentially toxic metal and mediates its excretion into the bile. Mutations in the ATP7B …
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