Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"recycling endosome"”.
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A novel pathway for VLDL assembly in the mouse liver
… Kompartiment, wahrscheinlich dem TGN oder dem "recycling endosome", transportiert, um lipidiert und als VLDL, in geringerem Umfang auch als IDL, sezerniert zu werden. Diese Daten beweisen, dass als LDL endozytiertes apoB100 zur Synthese von VLDL wiederverwendet werden kann. Eine solche …
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Identification and Characterization of Effectors/Binding Molecules for the Small GTPase Rab15
… receptor internalization into early endosomes. Here internalized receptors are\r\nsorted for degradation in lysosomes, direct recycling back to the cell surface or indirect\r\nrecycling via a second recycling compartment called the pericentriolar recycling\r\nendosome. Rab GTPases …
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Molekulargenetische und funktionelle Untersuchungen zu autosomal-rezessiv erblichen Neuropathien
… with marker proteins of the pericentriolar recycling endosome. Given its predicted domain structure, KIAA1985 belongs to a group of possible adapter proteins. Therefore interaction partners of KIAA1985 should be identified. One of these identified interactors was the small GTPase Rab11, a …
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Analysis of the function of Drop out, the single homologue of human MAST kinases, in <i>Drosophila</i> cellularisation
… <i>dop</i> mutants and Golgi as well as recycling endosome localisation are affected, suggesting a function of Dop in membrane recruitment via both Dynein and Kinesin microtubule motors. Furthermore, the localisation of the Dynein subunit Dynein light intermediate chain (Dlic) displays …
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An Oxanthroquinone Derivative Disrupts Ras Plasma Membrane Localization and Function By Inhibition of Acylpeptide Hydrolase and Perturbation of Sphingomyelin Metabolism
… proteins remaining on the PM. G01 also inhibited recycling of epidermal growth factor receptor and transferrin receptor, but did not impair internalization of cholera toxin, indicating suppression of recycling endosome function. In searching for the mechanism of impaired endosomal recycling we …
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Anaplasma phagocytophilum remodels its host cell-derived vacuole into a protective niche by redecorating the vacuolar membrane with select Rab GTPases and bacterial proteins
… Rabs that are predominantly associated with recycling endosomes. Another emerging theme among vacuole-adapted pathogens is the ability to hijack ubiquitin machinery to modulate host cellular processes. Mono- and polyubiquitination differentially dictate the subcellular localization, activity, …
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On connections between metazoan cellular metabolism and cell size
… proliferation ratio. Geranylgeranylation of the recycling endosome regulating protein RAB11 was identified to be at least partially responsible for the cell size regulation by the mevalonate pathway. Furthermore, the link from the mevalonate pathway to RAB11 was found to regulate basal autophagic …
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Understanding Primate Immunity to African Trypanosomes Through the Characterization of Trypanosome Lytic Factor Formation and Function
… and some to the plasma membrane via the recycling endosome. APOL1 on the surface opens a non-selective cation channel due to the neutral pH. This channel allows sodium and calcium to influx down their concentration gradients. This influx of positive ions causes plasma membrane …
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RNA binding proteins in neurotoxic protein clearance
… of the Golgi complex, defective fission of the recycling endosome, and perturbations in the microtubule cytoskeleton. While future research is required to uncover the precise mechanism by which this protein facilitates vesicle trafficking and maintains the architecture of the Golgi apparatus, …
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Characterising ATP13A3 biological function and its role in pulmonary arterial hypertension
… I first confirmed ATP13A3 as residing in the recycling endosome of endothelial cells. This localisation of ATP13A3 suggested it might be related to polyamine transport since the endocytic pathway was recognised as a crucial route for polyamine trafficking. To expand this finding, I developed …
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Protein Trafficking of BK Channel β1 Subunits in Cerebral Artery Myocytes
… which regulated by Rab11A- positive recycling endosomes. Endothelin-1 (ET-1), a vasoconstrictor, induces contraction of myocytes. ET-1 inhibits BK channel but mechanisms are not fully understood. It is unclear that vasoconstrictors regulate the cellular distribution of BK channels. …
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The Regulation of Segmentation Clock Period in Zebrafish
… particular endocytic compartment, potentially a recycling endosome, in a ubiquitin-dependent manner, where its signaling ability might be established or amplified by an as yet unknown posttranslational modification. In the present study, Delta trafficking through the endocytic pathway was …
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Characterization of Fluorescent biosensor for Rab11 GTPase
L'abstract è presente nell'allegato / the abstract is in the attachment