Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"recurrent tumours"”.
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Exploring the Potential use of TEAD Inhibition as Part of a Combination Therapy for NF2-Deficient Schwannoma and Meningioma.
… of schwannoma, meningioma and ependymoma tumours. Although surgical resection and adjuvant radiotherapy can be used, new avenues of therapeutic development are essential to target inoperable and recurrent tumours. Previous studies evaluating small molecule TEAD auto-palmitoylation …
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A clinicopathological and molecular genetic analysis of low-grade glioma in adults
… promoter methylation when partially methylated tumours were grouped with methylated tumours. Grade II and grade III tumour comparison analysis revealed 14 novel significant miRNAs with differential expression. A miRNA signature was shown for histological subtypes, oligoastrocytoma and anaplastic …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… treated with radiotherapy or surgery where recurrent tumours are treated with hormone therapy, such as androgen-deprivation therapy (ADT) and/or androgen receptor (AR) antagonists, e.g. Enzalutamide (ENZ). Castrate-resistant disease, where tumours become resistant to hormone therapy, is …
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Novel approaches and pharmacological considerations in melanoma treatment
… Active-targeting enables NP accumulation in tumours using targeting-moieties designed to recognise tumour-associated molecular markers.<br/><br/>Super-paramagnetic (SP) iron oxide nanoparticles (SPIONs) have been selected and synthesised in-house as a drug delivery platform.3 These …
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The relationship between BRAF genetic alterations and the risk of tumour recurrence in Pilocytic Astrocytomas in children diagnosed at Red Cross Children's Hospital over a 33-year period
… are the most common central nervous system (CNS) tumours reported in the paediatric population. 1 PAs are circumscribed astrocytic gliomas associated with a favourable overall survival and thus regarded as low grade by the World Health Organisation (WHO), with a reported five-year survival rate …
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Effect of ATF2 transcription factor on DLL4 gene expression in angiogenesis
INTRODUCTION: ATF2 belongs to the AP1 transcription factor family that homodimerize or heterodimerize with other members of the bZIP family and regulates the transcriptional activation of target genes. Previous studies have shown that ATF2 mediates VEGF-induced angiogenic processes but the …
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Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… still show rapid recurrence of resistant tumours leading to patient fatality with less than 5% surviving beyond 5 years. Treatment and development of therapeutics for GBM is hampered by a highly complex disease that displays vast amounts of inter and intra-patient heterogeneity. This is …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… profiling of the primary, metastatic and recurrent tumours. Circulating tumour cells (CTC) and circulating tumour DNA (ctDNA) represent a new generation of biomarkers that can be used for predicting therapy responsiveness and longitudinal monitoring of OC patients undergoing therapy. This …