Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"recurrence risk"”.
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Do Finances Determine Our Fate?: Understanding the Relationships Between Socioeconomic Status, Inflammation, and Cancer Recurrence Risk
… (SES) are more likely to experience a cancer recurrence relative to individuals with a higher SES. This may be partially explained by the stressors of living with a low SES. These stressors can increase inflammatory markers known to elevate the risk of cancer development. Health-promoting …
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Identifying Interest In and Barriers to Psychiatric Genetic Counseling
… understand multifactorial inheritance, recurrence risk estimates, and identify ways to protect their future mental health. Despite interest in and efficacy of the service documented in populations outside of the United States, individuals with personal and/or family histories of …
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Approach to congenital disorders: referral pathways for genetic services in the Eastern Cape
… the implications for management and for recurrence risk in the family remains unclear. The burden of these disorders in low middle-income countries (LMIC) is underappreciated. Referral to genetic services aids in diagnosis, management, and the interpretation of the family history to …
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Expression of Survivin : Possible Predictor of Local Recurrence after Curative Resection for Rectal Cancer
Local recurrence has always been a challenging problem following rectal cancer surgery, desite of the advances in surgical technique(TME) as well as adjuvant therapy(preoperative CCRT). There is a need for better prognostic markers due to the varieties of treatment response within same …
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Efficacy of Genetic Testing Methodologies for Prenatal Detection of Skeletal Anomalies and Craniosynostosis Syndromes
… molecular testing to provide accurate diagnosis, recurrence risk, and guidance for families. </p>
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The effect of previous preterm birth on the risk of recurrent preterm birth in Iceland 1997-2018
… preterm birth and maternal age are known risk factors for preterm birth. Studies have shown a higher recurrence risk with a lower gestational age in the previous birth and that the clinical subtype of preterm birth is likely to recur. There is no current evidence regarding the risk of …
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Machine-Guided Biopsy Analysis in Oncology: Facilitating Diagnostic Access and Biomedical Discovery Through Deep Learning
… networks to facilitate the detection of high-risk human papillomavirus (HPV) DNA in a point-of-care diagnostic device, facilitating deployment in resource-limited settings. In the second, we develop a comprehensive computational pipeline for cyclic fluorescent microscopy analysis. We iden- …
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Metabolomic Biomarkers for Colorectal Cancer
… patients, and a novel workflow for estimation of recurrence risk using high-dimensional data is proposed. Challenges and pitfalls confronted in different steps of the project were addressed when possible by the use of available methods. Where no reliable method was available, we made an effort to …
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The pathophysiology of chronic subdural haematoma and the role of the dexamethasone
… recent haemorrhage indicated an increased CSDH recurrence risk. This work was performed alongside the Dex-CSDH trial, a randomised, placebo-controlled trial of the potent anti-inflammatory dexamethasone. Blinded interim results of the trial are discussed, but the main focus are the scientific, …
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Genetic Counselors' Experiences With and Approaches to Discordant Genotypic and Phenotypic Sex Detected Via Non-Invasive Prenatal Testing
… results, sharing information with others, and recurrence risk, but discomfort regarding the discussion of genital surgeries. GCs ranked discussion of differential diagnosis, testing options, and parental support as the most important topics for an initial NIPT-DSI genetic counseling session. …
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Molecular profiling in early stage IB1 squamous cell carcinomas of the uterine cervix.
… non-radical surgical resection and pose little risk of recurrence and metastasis. On the other extreme, cancers that are inoperable, due to spread beyond the cervix (Stage IIB to IVB) require concomitant chemotherapy and radiation therapy. Currently, of all women undergoing radical …
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An assessment of diagnosis and prognostication in cardioembolic transient ischaemic attack and ischaemic stroke
… known causes with different profiles of vascular risk factors and recurrence risk. Cardioembolic events account for approximately a third of incident stroke. The aim of my thesis has been to assess current methods of identifying cardioembolic source of TIA and stroke, examine the prevalence of …
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A Study of Guideline for Genetic Counselling in Preimplantation Genetic Diagnosis (PGD)
… the possibility of unexpected results and the recurrence risk (51.7%), and the reproduction options (46.7%). Approximately 96.7% of specialists replied that non-MD genetic counselor is necessary for effective and systematic genetic counselling in PGD because it is difficult for physicians to …
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The Risk of Seizure Recurrence Following a First Unprovoked Seizure in Childhood: An Extended Follow-Up
… these reasons, informations with regard to the recurrence rate following a first unprovoked seizure and the predictors of risk factor of seizure recurrence are important for the decision of rational AEDs treatment. Therefore, we performed a long-term prospective study to evaluate the recurrence …
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A Systems Approach to Modelling Tumour and Tissue Response in Radiotherapy for Head-and-Neck Cancer
… ranging from severe toxicities to loco-regional recurrence (LRR). Multi-modal biomarker data—encompassing genetic, dosimetric, and imaging domains—offers an opportunity to address this variability by leveraging all routinely collected radiotherapy data to guide personalised treatment. However, …
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Investigating Potentially Arrhythmogenic Atrial Substrate using Computational Simulations and Explainable Machine Learning
… to distinguish populations of patients at risk for recurrent arrhythmias from those who will remain arrhythmia free following ablation. We identified the key population-level and patient-specific level risk factors for post-ablation recurrence. The explainable aspect of our approach allowed …
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Molecular Genetics of Usher Syndrome: Mutation Screening Studies and Discovery of the Usher Syndrome Type IIC Gene, the Very Large G-Protein Coupled Receptor (VLGR1).
… retinal deterioration. Genetic counseling of recurrence risk estimations will be more accurately assessed by knowledge of the distribution and frequency of mutations. As a prerequisite for mutation screening, the USH2A gene intron/exon organization was determined. Fifty seven USHII probands …
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Subclinical Phenotypes and Genotypes in Parents of Children with Non-Syndromic Cleft of Lip and/or Palate
… the sub-phenotypes of clefting will improve the recurrence risk estimation and provide more informative and genetically homogenous groups for gene mapping.<b><br/></b><b><br/></b><b>Aim</b>: To assess facial morphology, the prevalence of upper lip sub-epithelial orbicularis oris (MOO) defects and …
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Craniosynostosis in a South Africa population
… setting and aid in accurate prognosis and recurrence risk information for families.
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The relationship between BRAF genetic alterations and the risk of tumour recurrence in Pilocytic Astrocytomas in children diagnosed at Red Cross Children's Hospital over a 33-year period
… (point mutations and gene fusions) and the risk of tumour recurrence. Purpose: The overall aim of this study was to determine if BRAF genetic alterations impact patient prognosis. This was done by evaluating the expression of BRAF using immunohistochemistry (IHC), fluorescence-in-situ …
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