Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"recombinant vaccines"”.
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Characterization of avipoxviruses for use in recombinant vaccines
Pox viruses have been demonstrated in over 60 types of wild and exotic birds as well as domestic birds. Avipox viruses have been isolated and characterised from fowls, quails, canaries, parrots and lovebirds. This work describes the first isolation of a poxvirus from Jackass penguins (Spheniscus …
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Molecular Characterization of Fowlpox Virus Isolates and Evaluation of Recombinant Vaccines Generated for Protection Against Fowlpox and Reticuloendotheliosis
… a lack of adequate protection by current vaccines. To determine the probable causes for these outbreaks, field isolates were compared with the vaccine strains. Antigenic variation amongst the strains was evident in immunoblotting with polyclonal and monoclonal antibodies. Biological …
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The complexity of infectious laryngotracheitis virus: a focus on vaccination and challenge viruses
… embryo origin (CEO) vaccine. However, CEO vaccines can revert to virulent ILTV and cause outbreaks. One of the successes of the recombinant vaccines with gene inserts for ILT is that they do not revert to virulence, but do prevent ILT symptoms. However, these same recombinant vaccines do …
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Defending Wild Dogs: Population Dynamics and Disease in Endangered African Wild Dogs
… I found that vaccination with modified-live or recombinant vaccines, including annual boosters will be a key strategy in disease management going forwards. Vaccination of domestic dogs near wolf and wild dog populations, vaccination of wolves and wild dogs themselves, and a combination of the …
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Development and testing of recombinant B. abortus RB51 vaccine strains carrying M. tuberculosis protective antigens
… in mice. Here we report the construction of two recombinant strains of B. abortus vaccine strain RB51 capable of expressing mycobacterial antigens Ag85B, ESAT6 and Rv2660c. Our studies show that expression of mycobacterial antigens in strain RB51 lead to induction of antigen-specific immune …
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Identifying B-cell epitopes of African horse sickness virus serotype 4 recognised by antisera of immunised horses
… reversal to virulence. Inactivated and subunit vaccines have been tested but are not commercially available. Research towards recombinant vaccines that will offer protection without these limitations is thus ongoing. Identification and characterisation of antigenic regions on proteins has always …
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Immune responses against recombinant poxvirus vaccines that express full-length lyssavirus glycoprotein genes
… of pre- or post exposure treatments. Rabies vaccines have been available since the time of Pasteur, more that one hundred years ago. Since, vaccine research focused on the development of safer and more effective vaccines. Topics of current interest in the field of rabies vaccinology were …
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Study of the roles of Cyprinid herpesvirus 3 ORF134 in the biology of the infection
… safety/efficacy profile of the triple deleted recombinant. To reach this goal, a collection of recombinant strains were produced using BAC cloning technologies, characterized and tested in vivo for their safety/efficacy profile. The results obtained demonstrated that the ORF56-57 deletion is …
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Entwicklung neuartiger bakterieller Vektoren zur Übertragung von zellassoziierten Antigenen, DNA und RNA auf der Basis virulenzattenuierter L. monocytogenes
Listeria monocytogenes ist ein fakultativ humanpathogenes Bakterium und aufgrund seiner Fähigkeit, in Zellen des Wirtes einzudringen und sich im Zytoplasma der befallenen Wirtszelle zu vermehren, ein attraktiver Träger, um heterolog exprimierte Antigene in den MHC-I- und -II-Präsentationsweg …
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Development of plant-produced African horse sickness vaccines
… warming and climate change. Live attenuated vaccines (LAV) have been used with relative success for many decades, but carry the risk of reversion to virulence and/or genetic re-assortment between outbreak and vaccine strains. Furthermore, the vaccines lack DIVA capacity, the ability to …
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Engineered microneedles for transcutaneous vaccine delivery
… for the noninvasive delivery of subunit vaccines to the skin. We have utilized laser ablative micro-molding of poly(dimethylsiloxane) to generate bio resorbable poly(lactide-co-glycolide) micro-structured skin patches bearing -100 micron-scale needles arrayed across their surface. Upon …
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Novel expression and production of Foot-and-mouth disease virus vaccine candidates in Nicotiana benthamiana
… through prophylactic vaccination. Current vaccines on the market are chemically inactivated virus strains. However, these are not considered ideal due to the possibly insufficient inactivation which could fail to render the virus harmless. Research on recombinant vaccines which obviate the …
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The design, development and characterization of a self-replicating DNA expression technology
… protective immunity. Among current methods, DNA vaccines, generate highly specific T-cell immunity towards targeted antigens, and do not suffer from issues like misdirected vector targeted immunity, like viral based vectors. DNA vaccines, however, face a variety of their own weaknesses. These …