Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"receptors NMDA"”.
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An Examination of Hippocampal and Prefrontal Contributions to Spatial Learning and Memory using Immediate Early Gene Imaging
… activation by inhibiting ionotropic glutamate receptors (NMDA and AMPA) during or after spatial learning. We found novel evidence that the salience (or noticeability) of environmental cues significantly impacted the type of learning strategy used (i.e. simple or complex), and that increased …
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Modulation of The Receptor Gating Mechanism and Allosteric Communication In Ionotropic Glutamate Receptors
<p>Ionotropic glutamate receptors (iGluRs) found in mammalian brain are primarily known to mediate excitatory synaptic transmission crucial for learning and memory formation. The family of iGluRs consists of AMPA receptors, NMDA receptors and kainate receptors with each member having distinct …
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Tranexamic Acid Modulation of Excitatory and Inhibitory Amino Acid Receptors: A Potential Mechanism for Postoperative Seizures
… enhancing the function of excitatory amino acid receptors (NMDA, AMPA, and kainate receptors). Alternatively, TXA could cause disinhibition by reducing the activity of inhibitory receptors (GABA and glycine receptors). The purpose of this thesis is to identify molecular targets that are sensitive …
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Studies on preconditioning with adenosine, glutamate and ouabain in rat hippocampal slices
… is known to be mediated by activation of A1 receptors and ATP-sensitive potassium channels whilst excitotoxic preconditioning mainly involves stimulation of NMDA receptors, nitric oxide and most likely ATP-sensitive potassium channel activation. ATP-sensitive potassium channel openers such as …
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Mathematical models of cognitive processes
… and with a particular type of membrane receptors (NMDA receptors) active or inhibited. All these results agree with the data reported in Jiang et al. (2001) and in Binns and Salt (1996). The model suggests that non-linearities in neural responses and synaptic (excitatory and inhibitory) …
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Evaluación e intervención neuropsicológica en un caso de encefalitis autoinmune por anticuerpos contra los receptores N-metil-D-aspartato (NMDA)
… contra los receptores N-metil-D-aspartato (NMDA). Estamos ante un tipo de encefalitis autoinmune caracterizada por la presencia de anticuerpos que atacan los receptores cerebrales del glutamato NMDA. Inicialmente se suele presentar un pródromo no específico, seguido por síntomas …
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An analysis of morphological changes in visual cortical neurons after knocking down scaffolding proteins of glutamate receptors
NMDA receptor subunit changes have an important implication in synaptic development, learning, memory, and neuronal disorders. Previous studies have suggested that two membrane-associated guanylate kinase (MAGUK) family scaffolding proteins, SAP102 and PSD-95, are involved in the switch from …
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Understanding the activation-deactivation mechanism of glutamate receptor proteins at the single molecule level
… nervous system. These receptor proteins, such as NMDA and AMPA receptors, are structurally diverse and house multiple extracellular and intracellular binding sites, which can modulate activated (open) or deactivated (closed) states of the ion channel. The gating action (activation and …
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Pharmacology of a novel biased allosteric modulator for NMDA receptors
NMDA glutamate receptor is a ligand-gated ion channel that mediates a major component of excitatory neurotransmission in the central nervous system (CNS). NMDA receptors are activated by simultaneous binding of two different agonists, glutamate and glycine/ D-serine1. With aging, glutamate …