Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"receptor-tyrosine-kinase-inhibitor"”.
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… the feasibility of Linifanib (ABT-869), a multi-receptor tyrosine kinase inhibitor of VEGF and platelet derived growth factor (PDGF) receptor families, on radio-sensitization of HNSCC. The results show that Linifanib (ABT-869) can induce an antitumor effect and radio-sensitize HNSCC cells via …
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Characterisation and modulation of drug resistance in lung cancer cell lines
… resistant cells. Lapatinib, a growth factor receptor tyrosine kinase inhibitor synergised with P-gp substrate cytotoxics in P-gp over-expressing resistant cells. However, lapatinib treatment, at clinically relevant concentrations, also increased levels of the P-gp drug transporter in a …
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Anti-VEGF Therapy Modulates Immune Cell Infiltration and Function in Multiple Breast Cancer Models
… VEGF binds to and activates two primary VEGF receptors, VEGFR1 and VEGFR2. VEGFR2 is the primary angiogenic receptor, while the function of VEGFR1 is less defined. It is important to note that the VEGFRs are expressed on endothelial cells, tumor cells and on many host immune cells. Therefore, …
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The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… its effects by interacting with one of four receptors termed EPI-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical carcinomas. The initial aim of this study was to localise the site of expression of EP4 receptors in cervical squamous cell- and …
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Targeting bone-microenvironment-tumour cell interactions : IGF-1 receptor kinase inhibitors.
… injection techniques respectively. IGF-1 and its receptor are known to play important roles in both bone metabolism and breast cancer. Therefore a study of the effects of IGF-1 receptor inhibition on tumour cell – bone cell interactions was performed. In vitro studies showed that the novel IGF-1 …
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Einfluß von PTK787/ZK222 584, einem spezifischen Rezeptor-Tyrosinkinase-Inhibitor, auf Anatomie, Dichte, Permeabilität und Blutfluß in Tumorgefäßen im murinen Nierenzellkarzinom
… und anti-angiogene Wirkung des Rezeptortyrosinkinase-inhibitors PTK787/ZK222 584 konnte reproduziert werden. Die dopplersonographisch detektierte Reduktion der Blutflussgeschwindigkeit in Relation zum Gesamtkreislauf konnte reproduziert werden. Die Reduktion der Mikrogefäßdichte unter Therapie …