Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"receptor-regulation"”.
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Estrogen Receptor Regulation of Vitellogenin Gene Expression
… animal. The ontogeny of the estrogen receptor indicates that nuclear estrogen receptor is intimately involved with the initiation of vitellogenin gene transcription, but that the maximal rate of gene transcription is independent of the nuclear estrogen receptor concentration. De novo …
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The CD23 receptor-regulation of expression and signal transduction
… ersten Teil unserer Untersuchungen haben wir die Regulation der B-Zell-spezifischen Expression von CD23a analysiert. Pax-5 ist ein auf B-Zellen beschränkter Transkriptionsfaktor, welcher für die frühe und späte B-Zellentwicklung von entscheidender Bedeutung ist. Mögliche Pax-5 Bindungsstellen …
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Estrogen Receptor Regulation of Xenopus Laevis Vitellogenin Gene Expression
… mechanism by which the Xenopus laevis estrogen receptor mediates the transcriptional response of the vitellogenin gene was investigated. The Xenopus estrogen receptor (XER) cDNA was cloned and sequenced. It could encode a protein of 66 Kd, which is approximately the same size as human and …
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Progesterone Receptor Regulation of the Gene Networks That Control Ovulation in Mice
… its biological effects through the progesterone receptors (PR), has emerged as a key regulator of ovulation. The development of progesterone receptor (PR)-null mice, which are unable to ovulate, revealed a critical role of this receptor in the control of follicular rupture. This animal model has …
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G protein-coupled receptor regulation: The role of protein interactions and receptor trafficking
The superfamily of G protein-coupled receptors (GPCR) is the largest gene family in the human genome. GPCR-mediated signaling operates in every human cell, and about 50% of existing clinically useful drugs act through GPCR. Kinins are proinflammatory peptides that are rapidly produced …
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Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors
… its major actions as a noncompetitive NMDA receptor (NMDAR) antagonist. Administration to immature rats has been shown to cause neurotoxicity in a regional and treatment dependent manner and development of schizophrenic-like behaviors later in life. The purpose of this study is to determine …
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Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
… To identify genes involved in the hypothalamic regulation of energy homeostasis, we employed a screen to search for genes that were dysregulated in GTG induced obese mice. In this screen, GPR7, the endogenous G protein-coupled receptor (GPCR) for the recently identified ligands neuropeptide B …
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Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, regulates both skin biology and carcinogenesis. We hypothesized that EGFR-dependent signal transduction increases normal keratinocyte proliferation and proliferation in response to ultraviolet (UV) irradiation, resulting in …
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Role of cyclin D1 as an estrogen receptor cofactor and the influence of hypoxia on estrogen receptor regulation, with focus on prognositic and treatment predictive features in breast cancer
Estrogen receptor (ER) status can define breast cancer patients who would benefit from adjuvant tamoxifen therapy. However, resistance to tamoxifen is often observed and possible mechanisms may be loss or reduction of ER, dysfunctional ER- signaling and ligand independent activation of the …
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An Evolutionary Computation Model of Intracellular Signaling Networks
… number of prerequisites. Two different signaling regulations, namely absence receptor regulation and presence receptor regulation, are represented in our network model. An evolutionary argument based on a minimum evolution hypothesis accounts for the empirical observation that an absence …
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CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
The regulated expression of cell surface receptors is essential for cellular homeostasis and defective in disease states. Receptor regulation is particularly important as receptor internalization limits the duration and intensity of substrate signaling. Interferon-γ (IFN-γ), a critical antiviral …
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Regulation of Iron Sequestration Systems in Escherichia Coli and Salmonella Typhimurium (Heme, Outer Membrane)
Regulation of iron uptake systems by iron, growth temperature, and heme was examined. Operon fusions were constructed in which the lactose utilization genes were fused to the promoter of the iron-regulated gene which encodes the colicin I receptor. Regulation by iron was shown to be at the level of …
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Characterisation of 11beta hydroxysteroid dehydrogenase 1 in ocular and orbital tissues
… of target genes through the glucocorticoid receptor (GR). The classical function of GR involves its interaction with glucocorticoid to influence transcription of genes involved in numerous physiological processes which include inflammation. The first line of defence in the ocular tissues …
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Growth-factor-induced mitogenesis: Trafficking determinants of the cellular response
… binding event between the growth factor and its receptor. However, the dynamics of the cellular trafficking of growth factors and their receptors can be an important determinant of the cellular response to growth factor stimulation. We have explored this hypothesis using the epidermal growth …
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The Regulation of Cholesterol Absorption: Nuclear Hormone Receptors and Niemann-Pick C1 Like 1
… border. In addition, members of the nuclear receptor superfamily of ligand-activated transcription factors are known to modulate expression of genes involved in cholesterol and bile acid homeostasis, and cholesterol absorption. Therefore, we wanted not only to clarify the essential molecular …
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Vascular receptor changes in ischemic stroke
… systems in cerebral arteries. To study vascular receptor changes in ischemic stroke transient focal ischemia was induced in rats. In addition, rat cerebral arteries and arterial smooth muscle cells were cultured for further analysis of cerebrovascular receptor regulation. For functional studies …
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Regulation and desensitisation studies on the nicotinic acid receptors
… Fifty years on from its arrival on the market, receptors which this drug acts upon have recently been identified as the G protein-coupled ‘nicotinic acid receptors’. A family of three highly homologous receptors, HM74, HM74A and GPR81 are characterised by their differing affinities for nicotinic …
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Regulation of natriuretic peptide system activation:effects of spontaneous natriuretic peptide mutations and identification of novel natriuretic peptide receptor phosphorylation sites.
… and GC-B) are transmembrane guanylyl cyclase receptors that mediate the physiologic effects of natriuretic peptides, including reduction of blood pressure and blood volume, stimulation of long bone growth, and regulation of cardiac size. Atrial natriuretic peptide (ANP) and B-type natriuretic …
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Studies on the optimization of expression and purification & Functional characterization of Class C – GPCRs
G-protein coupled receptor (GPCRs) is a multigene family consisting of more than 1000 genes. They are the most abundant membrane proteins found on a cell surface and are involved in several signaling pathways. In a cell, the signal is transduced by diverse activating endogenous ligands binding on …
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