Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"receptor signalling"”.
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Regulation of FGF Receptor signalling by SPROUTY and SPRED
Signalling from Fibroblast Growth Factor Receptors (FGFRs) is under tight control by a wide variety of extrinsic and intrinsic regulatory mechanisms, many of which remain poorly defined. Sproutys and their related Spred proteins constitute two such families of signalling regulators with multiple …
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Proton-sensing G protein-coupled receptor signalling in inflammation
… responses through a number of proton-sensitive receptors including both ion channels and G protein-coupled receptors, many of which are expressed by immune cells and sensory neurones, the principal drivers of inflammation and nociception respectively. While proton-sensitive ion channels, such as …
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Characterisation of Androgen Receptor Signalling and Metabolism in Prostate Cancer
… which affects men worldwide. The Androgen Receptor (AR) is responsible for driving disease progression, therefore therapies often target this signalling axis. Eventually, these treatments fail and the cancer progresses to an aggressive, incurable stage known as castrate-resistant prostate …
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Investigating persistent organic pollutants as endocrine disruptors of androgen receptor signalling
… a part of everyday life and may mimic hormonal signalling in wildlife and humans. These exogenous mixtures or substances are called endocrine disrupting chemicals and may lead to adverse health effects in those exposed. Persistent organic pollutants (POPs) are a class of organic compounds that …
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MAPPIT analysis of the early events in Toll-Like receptor signalling
… van T and B lymphocyten die antigen-specifieke receptoren expresseren. Door deze clonale selectie en expansie is de adaptieve respons pas volledig operationeel drie tot vijf dagen na infectie. De aangeboren respons daarentegen vormt de eerstelijnsdefensie tegen pathogenen en is daarom essentieel …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and antioestrogens), which are successful in many patients, but therapy resistance represents a major clinical issue. The Androgen Receptor …
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Computational and experimental investigation of G protein-coupled receptor signalling mechanisms
G Protein-Coupled Receptors (GPCRs) are 7-transmembrane domain proteins. These receptors translate extracellular stimuli into cellular responses through heterotrimeric G proteins and β-arrestin proteins. These receptors are of considerable therapeutic interest, targeted by over 500 drugs approved …
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Epidermal growth factor receptor signalling regulates ommatidial rotation during Drosophila eye development
… identified that disrupt this process and the signalling pathways regulating ommatidial rotation remain yet to be revealed. This study characterizes the argosroulette mutation, in which ommatidia rotate to various degrees. Argos is a secreted inhibitor of Spitz, the main activating ligand of …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
The insulin receptor (InR) is a central regulator of metabolism, growth, and proliferation in both humans and *Drosophila*. Integrating a range of signals, InR coordinates pleiotropic, tissue‐specific outputs. Neural stem cells (NSCs) give rise to the vast range of cell types that comprise the …
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An investigation into the role of Bcl-3 in toll-like receptor signalling
… of potentially harmful stimuli, Toll-like receptors (TLRs) initiate the innate immune response and induce the expression of hundreds of immune and pro-inflammatory genes. TLRs are critical in mounting a defence against invading pathogens however, strict control of TLR signalling is vital to …
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
… cells downstream of the antigen recognition receptors, the signals from which are crucial for the development, differentiation and activation of lymphocytes. Engagement of the T cell antigen receptor (TCR) initiates a signalling cascade leading to the rapid induction of PI3K activity. The …
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Exploring the molecular basis to the regulatory effects of Cannabinoids on toll-like receptor signalling
Toll like receptor (TLR) signalling is central in controlling innate immune responses, with dysregulation of TLR pathways associated in both autoimmune and inflammatory diseases. Numerous reports suggest that cannabinoids, known to exhibit general immunosuppressive properties, have potential …
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The interplay of sodium and voltage in the regulation of G-protein coupled receptor signalling
… role in cell signaling, G-protein coupled receptors (GPCRs) form the largest superfamily of membrane proteins and approximately a third of all drug targets in humans. The membrane potential is one of the defining characteristics of living cells. Recent work has shown that the membrane …
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Investigation of hypothalamic molecular mechanisms underlying narcolepsy and obesity through DNMT1 and leptin receptor signalling
… to identify proteins that regulate human leptin receptor (LEPR) signalling, since leptin signalling is essential for normal body weight regulation. Several candidate proteins were identified that may negatively regulate signalling through LEPR and are of potential therapeutic relevance for …
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The molecular actions of medroxyprogesterone acetate on androgen receptor signalling and the promotion of breast cancer.
… MPA possesses antagonistic actions on androgen receptor (AR)-signalling and thereby can disrupt the protective effect of androgens in the breast, thus leading to an increased risk of breast cancer. Androgens have been associated with a growth restrictive role in breast tissue in both humans and …
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Characterisation and therapeutic modulation of toll-like receptor signalling in response to the intracellular pathogen F. tularensis
… of the invading organism and the generation of a signalling cascade leading to the production of inflammatory mediators. Toll-like receptors are expressed on multiple cell types and induce the activation of a complex network of signalling pathways containing numerous branches with multiple …
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
Group I metabotropic glutamate receptors (mGluRs) - mGluRl and mGluR5 - are believed to contribute to neuronal death upon overstimulation and may be neuroprotective under other conditions. To develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified …
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Prostaglandin EP3 receptor signalling as a contributor to sex differences in stress-related disorders mediated by the locus coeruleus
… disorders. Within this framework, prostaglandin signalling, particularly through the EP3 receptor expressed in LC neurons, has emerged as a key modulator of stress, nociception and affective behaviour, providing a mechanistic link between sex differences, stress regulation and chronic pain. The …
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A novel antigen-receptor signalling reporter mouse reveals clonotype-independent intratumoral trapping as a spatial feature of CD8+ T cell exhaustion
… developed a novel mouse model, termed Antigen-Receptor Signalling Reporter (AgRSR) mouse, that uses the specificity of Nur77 (NR4A1) for antigen receptor activation to drive expression of a tamoxifen-inducible CreERT2, enabling time-stamping of TCR-activated lymphocytes with EYFP expression …
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