Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 210 for “"receptor expression"”.
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Ryanodine receptor expression in trophoblasts
… essential in fetal skeleton formation. Ryanodine receptors (RyRs) are high conductance cation channels that mediate Ca2+ release from intracellular stores to the cytoplasm. To date, the roles of RyRs in trophoblasts have not been reported. By use of reverse transcription PCR and western blotting, …
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TOLL-LIKE RECEPTOR EXPRESSION AND FUNCTION
… yet little is known about the role of toll-like receptors (TLR) which, upon activation, stimulate inflammation. The objective of this research was to determine: (1) baseline expression of TLRs in ocular surface cells, if TLR activation or products thereof (antimicrobial peptides, AMPs) can …
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Regulation of ethylene receptor expression in Arabidopsis
<p>The ethylene receptor family of Arabidopsis consists of five members, ETR1, ETR2, ERS1, ERS2, and EIN4. Regulation of ethylene receptor expression in Arabidopsis was studied using three different approaches. First, the effect of ethylene-pathway mutations upon expression of ETR1 was examined. …
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Exercise-induced alterations in melanocortin receptor expression and inflammation
… dissertation is novel in that it explores the expression of the melanocortin receptors (MCR) on the plasma membranes of systemic monocytes, indicating a novel role for the MCRs as anti-inflammatory receptors that are regulated by chronic exercise training. The melanocortin 1 receptor (MC1R) and …
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… work focuses on the ability of IL-27 to promote expression of inhibitory receptors on T cells. The studies presented here establish that TCR and cytokines have distinct and complementary roles in promoting inhibitory receptor expression. In vitro, IL-27, type I IFN, and IFN-g induced expression …
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… mellitus and obesity induces alterations in the expression of cannabinoid receptor 1 (CB1), cannabinoid receptor 2 (CB2) and putative cannabinoid receptor G-protein coupled receptor 55 (GPR55) in a tissue specific manner. Renal expression and function of these receptors, particularly within the …
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Employing High Probability Gene Choice Elements to Understand Singular Odorant Receptor Expression
… sensory neurons (OSNs), which express odorant receptors (ORs) that bind to chemical odors in the environment. In order to increase specificity and sensitivity, an essential property in olfaction is for each OSN to express an OR in a monogenic and monoallelic fashion. Out of a large repertoire …
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5-HT1A receptor expression : Studies in postmortem tissue and characterisation of a model system.
… is mediated by somatodendritic 5-HT[1A] autoreceptors. The presence of 5-HT[1A] receptor is thought to be increased in depressed patients, producing a reduction in the synthesis of 5-HT. A common single nucleotide polymorphism in the promoter region of 5HT[1A] receptor C-1019G is also …
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The pattern and functional consequence of Killer Immunoglobulin-like Receptor expression on T cells.
Killer immunoglobulin-like receptors (KIRs) are a family of proteins expressed on human natural killer cells and a subset of T cells. Several inhibitory KIRs have been shown to recognise MHC class I molecules (predominantly HLA-C), with their engagement preventing target cell lysis. The ligand(s) …
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Interleukin-10 Suppresses Mast Cell IgE Receptor Expression And Signaling In Vitro And In Vivo
… Interleukin-10 mediated regulation of FcεRI expression and related downstream signaling molecules, and to determine how this affects mast cell function in vitro and in vivo.Methods: Mast cell FcεRI expression was evaluated with and without IL-10 treatment in human lung and skin mast cells, …
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Regulation of tumour necrosis factor receptor expression on neutrophils by arachidonic acid and other long chain fatty acids.
… cytokine with multiple biological effects. The receptors for this cytokine on neutrophils have been shown to be rapidly down-regulated following activation, leading to the release of soluble forms of these receptors. Thus neutrophils become less responsive to TNF and the soluble TNF receptors …
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Imaging Nociceptin Receptor Expression in Cannabis Use and Psychosis using Positron Emission Tomography with the radioligand [11C]NOP-1A
… dysregulation of nociceptin opioid peptide receptor (NOPr) signaling can result in neurotransmitter imbalance, suggesting its putative role in substance use disorder and psychosis. Furthermore, N/OFQ has been demonstrated to be involved in the brain’s stress response and in cognitive …
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KGF-1 and KGF receptor expression in human periodontal disease and in vitro microwounding-associated-ligand-independent KGFR activation
… epithelial-specific Keratinocyte Growth Factor Receptor (KGFR). First, we examined KGF-1 and KGFR expression and localization in human periodontal tissues. Second, we extended these studies by developing an in vitro mechanical wound model to mimic trauma to the periodontal pocket epithelium and …
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Toll-like receptor expression and signalling in rat trigeminal neurons: Consequences for oral infection and mechanisms of orofacial pain.
The activation of Toll-like receptors (TLRs), expressed by peripheral sensory neurons, represents an innate surveillance function of sensory neurons with important consequences for neuronal function. Despite recent advances, many properties of neuronal TLRs remain poorly understood, particularly …
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