Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"receptor editing"”.
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Transcription, Editing, and Switching of Antibody Genes
… shown to be silenced by deletion, anergy, and receptor editing. While anergy and deletion physically eliminate the autoreactive clone, receptor editing salvages it by replacing its immunoglobulin receptor through ongoing V(D)J recombination. Once a functional non-self -reactive receptor is …
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Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)
… by B cells such as somatic hypermutation, receptor revision (... CDR replacement), receptor editing (chain shuffling), and amino acid insertions and deletions. Together with yeast surface display and flow cytometric screening (FACS), this approach has been used to effect at least a five …
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The Role of Foxo Transcription Factors in B Cell Development and Activation
… effector cell types. Signaling from the B cell receptor (BCR) plays a critical role at several points during this developmental process. Cell survival, proliferation, differentiation, death, anergy, and receptor editing may occur in response to BCR stimulation. A variety of factors, including …
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MODULATION OF THE B-CELL REPERTOIRE IN RHEUMATOID ARTHRITIS BY TRANSIENT B-CELL DEPLETION
… results in changes of the peripheral B-cell receptor repertoire. To address this issue, expressed immunoglobulin genes of two patients suffering from RA were analysed; one patient for the heavy chain repertoire (patient H), one patient for the light chain repertoire (patient L). Both patients …
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Golgi Specificity and Development of Autoreactive B Cells
<p>B cell receptors with certain heavy/light chain pairs predominate in the periphery of anti-DNA heavy chain transgenic mice while certain other B cell receptors are absent. We wanted to know why. To answer this, we re-constructed B cell receptors represented in the anti-DNA transgenic mice by …
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B cell signalling in mechanisms of central and peripheral tolerance
… example, antigen-driven ligation of the B cell receptor (BCR) on immature B cells results, by default, in receptor editing, anergy and/or apoptosis, whereas it provides survival, proliferative and effector differentiation signals to mature B cells. Moreover, various factors can influence the …