Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"receptor down regulation"”.
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
… and Th2 (IL-4 and IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood and constituted the major aim …
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Down-modulation of the apoptosis receptor Fas and the EGF receptor by the adenovirus E3/10.4-14.5K proteins requires the concerted action of two distinct transport signals
… of the EGFR and selective members of the TNF/NGF receptor superfamily, namely Fas/CD95 and TRAIL-R1, whereas TRAIL-R2 modulation additionally requires E3/6.7K. In a process referred to as receptor down-regulation, 10.4-14.5K relocates receptor targets from the cell surface to lysosomes for …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… blood cell production and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these phosphotyrosines through SH2 domains, leading to the …
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The Role and Mechanism of Enhanced Met Expression in Pancreatic Cancer
… tumor growth using shRNA mediated knock down of Met in two pancreatic adenocarcinoma cell lines. I showed that cells with reduced Met protein exhibited reduced growth in soft agar, cell motility and tumor growth in vivo; supporting the conclusion that the HGF/Met signaling axis functions …
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Evaluation of the oral delivery of goserelin with Pheroid® technology
… axis, consequently leading to receptor down-regulation, which in turn leads to the inhibition of the secretion of the pituitary gonadotropins. This causes a decrease of endogenous testosterone in males and oestrogen in females. Through this, a hypogonadal status is achieved. …