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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 183 for “"receptor binding"”.

  1. Receptor Binding Domains and Coronavirus Adaptation and Evolution

    Wong, Alan2018

    … is a viral membrane protein involved in host receptor binding and fusion of the viral and host cell membranes. Reported here is work performed on the spike proteins of two human common cold causing coronaviruses: HCoV-229E and HCoV-OC43. Specifically, the X-ray crystal structures of the …

    toronto-retro Repository record

  2. Glycan receptor binding determinants of Influenza A virus hemagglutinin

    Koh, XiaoyingMassachusetts Institute of Technology2010

    … hemagglutinin (HA), which changes its binding specificity towards glycan receptors in the human upper respiratory epithelia (referred to as human receptors). In this thesis, determinants that mediate changes in HA-glycan receptor binding specificity are investigated, with focus on the …

    mit Repository record

  3. Synthesis and androgen receptor binding of novel derivatives of dihydrotestosterone

    Stobaugh, Mark Edward1990

    This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

    iupui Repository record

  4. Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras

    McAuley, Alexander JThe University of Texas Medical Branch at Galveston2019

    … uncertain, but potentially involves the putative receptor-binding domain of the envelope glycoprotein, domain III (EIII). In order to determine the tolerance for heterologous sequences, and to characterize the role of EIII in virus growth and tissue tropism, chimeric viruses were generated using …

    utmb Repository record

  5. Study of Receptor Binding and Growth Effect of Gastrin Gene Products

    Wibowo, Felicitas I.Creighton University2002

    … for its biological effect through the CCK2 receptor. Structure-functional studies of gastrin and the CCK2 receptor revealed the importance of Phe in residue 17 of gastrin in receptor recognition. Removal of Phe" abolishes the binding of gastrin to the human CCK2 receptor but leads to an …

    creighton Repository record

  6. Engineering and targeting glycan receptor binding of influenza A virus hemagglutinin

    Jayaraman, AkilaMassachusetts Institute of Technology2011

    … the host infection by influenza A virus is the binding of the viral surface glycoprotein hemagglutinin (HA) to the sialylated glycan receptors terminated by N-acetyineuraminic acid (Neu5Ac) expressed on the host cell surface. Glycans terminating in Neu5Ac that is a2-6 and a2-3 linked to the …

    mit Repository record

  7. The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding

    Lord, Janet MaryAston University1983

    … is concerned with the regulation of insulin receptors, with respect to receptor number, affinity and certain postreceptor effects of insulin action. The Aston obese hyperglycaemic (ob/ob) mouse was used as an animal model of obesity and type 2, NID diabetes mellitus. Hepatocyte insulin …

    aston Repository record

  8. Design, Synthesis and Biological Properties of Estrogen Receptor Binding Breast Tumor Localizing Agents

    Senderoff, Stephen GaryUniversity of Illinois at Urbana-Champaign2014

    … in vitro evaluation for usefulness as estrogen receptor binding radiopharmaceuticals. Two of these compounds, 16(alpha)-bromoestradiol-17(beta) and 11(beta)-methoxy-16(alpha)-bromoestradiol-17(beta) exhibited high binding affinity for the estrogen receptor, and were predicted to exhibit high …

    uiuc Repository record

  9. The protein structures underlying receptor binding and membrane fusion of ecotropic murine leukemia viruses

    Fass, Deborah, 1970Massachusetts Institute of Technology1997

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.

    mit Repository record

  10. Investigating the role that Interleukin-10's receptor binding properties play in defining its biological activities

    Gorby, ClaireUniversity of Dundee2021

    … naturally as a dimeric molecule which binds two receptor subunits: IL-10Rα and IL-10Rß. It has very poor affinity for the IL-10Rß receptor subunit and is unable to bind IL-10Rß in the absence of IL-10Rα (Walter, 2014). Using error-prone yeast display we were able to generate a variant of IL-10 …

    dundee Repository record

  11. Preparation of a site-specific lymphotoxin- mutant to be used in protein characterization and receptor binding studies

    Knight, Derek Andrew

    csusb-retro Repository record

  12. Preparation of a site-specific lymphotoxin- mutant to be used in protein characterization and receptor binding studies

    Knight, Derek Andrew

    csusb Repository record

  13. The Effect of Retinoic Acid on Rai1 and Identification of Retinoic Acid Receptor Binding Site in Human Rai1

    Xue, Bingjie2019

    Previous studies showed haploinsufficiency of RAI1 is the main cause of Smith-Magenis syndrome (SMS). SMS is a developmental neurobehavioral syndrome characterized by intellectual disability, congenital anomalies, obesity, neurobehavioral abnormalities, and disrupted circadian sleep-wake pattern. …

    vcu Repository record

  14. Determinants in the pandemic H3N2 influenza A virus hemagglutinin that affect receptor binding and transmission in the pig

    Van Poucke, SjoukeGhent University. Faculty of Veterinary Medicine2013

    Bij het ontstaan van pandemische influenzavirussen wordt een bijzondere rol toegeschreven aan het varken. Deze dieren zijn infecteerbaar met zowel aviaire, humane als porciene isolaten. Ze worden daarom verondersteld te functioneren als tussengastheer voor de overdracht van aviaire influenzagenen …

    ghent Repository record

  15. Energetic and dynamic characterization of the IgA1:FcαRI interaction reveals long-range conformational changes in IgA1 upon receptor binding

    Posgai, Monica ThereseUniversity of Cincinnati2012

    … immunoglobulin A (IgA) and the IgA-specific receptor, FcαRI, initiates a pro-inflammatory immune response in the presence of a multivalent antigen, and has recently been shown to possess an anti-inflammatory role in the absence of antigen. Additionally, soluble FcαRI has been implicated in …

    ohiolink Repository record

  16. Prediction of In-Vivo Antimuscarinic Activity (AMA) by In-Vitro Receptor Binding Assessment and PK/PD Modeling For Prototypical Drugs

    Obied, Taghrid Y.2014

    … having off-target interaction with muscarinic receptors, was performed. Prototypical drugs olanzapine, diphenhydramine, paroxetine were selected for the analysis. Scopolamine and darifenacin were included as positive and negative controls, respectively. Physiochemical properties, …

    vcu Repository record

  17. Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m

    Dannoon, Shorouk, 1982-University of Missouri--Columbia2009

    … (S₂N₂ and S₃N) were developed. Their in vitro receptor binding affinity toward somatostatin receptors was measured via IC₅₀ studies. In vitro stability studies were carried out under physiological conditions on ⁹⁹[superscript-m]Tc-cyclized analogues in phosphate buffered saline, mouse serum, …

    missouri Repository record

  18. The Effects of Chronic Ethanol on GABA Receptors in the Nonhuman Primate Brain

    Dolson, EugeniaWake Forest University2011

    … ethanol increases the function of the GABAA receptor, while chronic ethanol decreases function. Rodent studies have reported changes in gene and protein levels, receptor function, and receptor binding density in GABAA receptors and subunits after chronic ethanol, and changes in GABAB gene and …

    wfu Repository record

  19. Human adaptation of avian influenza viruses

    Srinivasan, KarunyaMassachusetts Institute of Technology2012

    … hemagglutinin (HA), that changes HA's binding specificity and affinity towards glycan receptors in the upper respiratory epithelia (referred to as human receptors). Unlike for the H1, H2, H3 and more recently H5 HA a correlation between the quantitative binding of HA to human receptors …

    mit Repository record

  20. Alterations of the Corticotropin Releasing Hormone Receptor System Following Early Life Stress and Ethanol Self-Administration in Rhesus Monkeys

    Trimnal, Megan WaddellWake Forest University2011

    … (HPA) axis function and CRH receptor binding. We used an accepted ELS model of maternal separation with nursery-reared (NR) and mother-reared rhesus monkeys induced to self-administer EtOH or control solution for over 12 months. Subjects underwent endocrine challenges to probe …

    wfu Repository record

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