Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"recent thymic emigrants"”.
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Recent Thymic Emigrants and their Biomarkers
… T cells that have just exited the thymus, called Recent Thymic Emigrants, are not yet fully matured and thus have different characteristics and functionalities than mature peripheral T cells. Several biomarkers exist for these Recent Thymic Emigrants in CD4 positive cells, but not in CD8 positive …
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Effects of Thymus Size and Involution On The Contribution of Recent Thymic Emigrants to The Peripheral T Cell Pool
<p>The contribution of recent thymic emigrants (RTEs) to the peripheral naïve T cell population is necessary to maintain diversity of the T cell receptor (TCR) repertoire and produce immune responses against newly encountered antigens.</p> <p>The thymus involutes with age, after irradiation or …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… 5 promoter-driven Cyclin D1 (K5.D1) transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent thymic emigrants (RTEs) undergo …
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Impact of Thymectomy on the Peripheral T Cell Pool in the Context of SIV Infection
… excisional circles (TREC) as a marker for recent T cell receptor (TCR) recombination in the thymus has proved to be an invaluable tool for the study of recent thymic emigrants. Here we describe the development of this technique in the rhesus macaque model and use this method in combination …
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The Influence of the Microbiota on T Cell Development
… and autoimmunity. This project will also look at recent thymic emigrants (RTEs). RTEs are the most immature subset and have been shown to have distinct phenotypes compared to mature naïve T cells (MNTs), including being more prone to differentiate into peripherally induced regulatory T cells, …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
Thymic epithelial lesions (TELs) are a heterogeneous and rare group of diseases arising from the epithelial cells of the thymus. TELs include both benign conditions, such as thymic hyperplasia (TH), and malignant lesions, collectively referred to as thymic epithelial tumors (TETs). According to the …