Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"reassortant viruses"”.
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Identification of reassortant influenza viruses at scale : algorithm and applications
… is the influenza A virus. Methods to identify reassortant influenza viruses do not scale well beyond hundreds of isolates at a time, because they rely on phylogenetic reconstruction, a computationally expensive method. This thus hampers our ability to test systematically whether reassortment is …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
… and segment reassortment between CVV lineages, reassortant isolates have emerged and has increased the genetic diversity of this virus. Importantly, recent case reports in humans have been associated with infection by these reassortant CVV strains. Pathogenesis studies in immune-compromised mice …
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Pandemic Potential of Reassortant Swine Influenza A Viruses
<p>Influenza A viruses are capable of causing disease in several species, including birds, humans and swine. Host specificity of the viruses is not absolute, and is influenced by a range of factors. Swine play a pivotal role in the interspecies transmission of influenza A viruses, as they are …
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Virologic Factors Contributing to the Genetic Diversification of Influenza Viruses Circulating in North American Swine
… mechanisms of reassortment of swine influenza viruses and determine if certain reassortant gene combinations can drive evolution and host adaptation in the context of the triple reassortant internal gene (TRIG) cassette. The TRIG contains a unique combination of a human polymerase basic 1 (PB1) …
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Investigation of Swine Influenza Virus Genetic Diversity and Evolution
… viral RNA segments in cells infected by multiple viruses can lead to a sudden shift in antigenicity. One such reassortant virus, the pandemic H1N1 (pH1N1) influenza virus was first reported in humans in the spring of 2009 and soon thereafter was identified in numerous species, including swine. …
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Matrix Gene Splicing and Emergence of Highly Pathogenic Avian Influenza
… unique regarding their M gene splicing. These viruses were capable of producing messenger RNA 4 (mRNA4), which had direct implications in the emergence of virulent viruses from this lineage. The avirulent viruses expressed mRNA4 at high levels. We demonstrated that there was strong selection …
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Reassortment of bluetongue virus vaccine serotypes in cattle
… cattle between BTV serotypes 11 and 17 where six reassortants with unique genetic profiles were described. In 2008, in Europe, segment 5 of BTV serotype 16 was identical to the South African vaccine strain of BTV serotype 2. In India in 2013 studies showed that in some isolates obtained from an …