Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"reactivity based screening"”.
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Stimulating antibiotic development by targeting virulence and facilitating natural product discovery
… aldehydes and ketones from microbial extracts based on the chemical reactivity of those carbonyl functional groups (chapter 3). This method is agnostic to the activity of the product and allows for the rapid identification of low abundance compounds that may be missed through activity-based …
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Natural product discovery in actinomycetes and investigation into the regulation of SPI-1 in salmonella typhimurium
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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Discovery and characterization of ribosomally synthesized and post-translationally modified peptide natural products
… metabolites whose structures can be predicted based on gene sequence and identity of tailoring enzymes within the biosynthetic gene cluster. Post-translational modifications installed by the tailoring enzymes in a site-selective manner endow the compounds with structural rigidity and, in many …
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Genomics as a tool for natural product structure elucidation
… midst of a transition from a largely serendipity-based effort to an informatics-driven one. For most of the 20th century, natural product discovery relied on genome-blind bioassay-guided isolation. This was initially exceptionally productive, yielding the golden age of antibiotics. The fact that a …
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Biomolecular NMR studies of the structure and biosynthesis of RiPP natural products
… natural product discovery to move from a blind screening approach to a bioinformatics guided approach. Screening of extracts for bioactivity is not only laborious, but also leads to the rediscovery of known compounds. With a genome-mining approach, bioinformatic analysis of natural product gene …