Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 531 for “"reactive oxygen species (ROS)"”.
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Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy
… Furthermore, this study used conjugation of reactive oxygen species (ROS) sensitive moiety which triggered the release of incorporated drugs in response to ROS in DR. Beta-cyclodextrin was conjugated with a ROS sensitive moiety (Ox-β-cyclodextrin), 4-(hydroxymethyl) phenylboronic acid pinacol …
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Exploring the role of reactive oxygen species (ROS) in marine ecosystem health and function
… of these ecosystem to prevent future loss. Reactive oxygen speices (ROS), such as superoxide and hydrogen peroxide, play an underappreciated role in both organism health and ecosystem biogeochemical cycles. This thesis lays the foundation to measure and identify ROS production by coral in …
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… morphology, an increase in BTG2expression and ROS level in response to doxorubicin treatment along with F-actin distribution in HDF cells, suggesting doxorubicin induced senescence phenotypes. However, TIS21 over expression reduced the phenotypes characterized by the morphological change, …
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The effect of sperm apoptosis, Reactive Oxygen Species (ROS) and semen sample handling on sperm parameters and Assisted Reproductive Technology (ART) outcomes
… and clinical impact of sperm apoptosis and reactive oxygen species (ROS) in the context of assisted reproductive technology (ART). This thesis encompasses three independent studies, each of which addresses a single aim related to different aspects of male infertility and ART practices. Study …
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A Multifunctional Solution Composed Of TMPyP, 1,5-DHN, And Fe(III) Ions That Produces Reactive Oxygen Species (ROS) In Aerobic, Anaerobic, And H2O2 Environments
… utilizes a photosensitizer, visible light, and oxygen, to produce reactive oxygen species (ROS) which can be used to treat cancer and inhibit growth of bacteria. In this study, a multifunctional solution that is comprised of Fe(III) ions, cationic meso-tetra(N-methyl-4-pyridyl)porphine …
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Development of novel reactive oxygen species (ROS)-modulating agents and carbonic anhydrase inhibitors for the treatment of Pancreatic Ductal Adenocarcinoma and other resistant cancers
In the present PhD thesis I propose the study and pharmacobiological optimization of a class of quinazolin-5,8-dione-based (QDs) compounds that showed promising antitumor activity against pancreatic ductal adenocarcinoma (PDAC) as well as other tumor types. In the same context of developing new …
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Does Sulfide Affect Short Term Iron Oxidation?
… chief intermediary in this process appears to be reactive oxygen species (ROS) generated by the concurrent partial reduction of dioxygen, although some reduced S species are known to react with Fe(III) directly. These overlapping potentials couple with the recurring oxidation and biogenic …
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ROLE FOR HYDROGEN PEROXIDE DURING ABIOTIC AND BIOTIC STRESS SIGNALING IN PLANTS
… is that they induce the accumulation of harmful reactive oxygen species (ROS). ROS, such as hydrogen peroxide (H2O2), are now also considered to be important signal molecules that regulate the defense response of plants to stress. In this thesis, different strategies were pursued to identify …
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NADPH oxidase in PC12 cell differentiation and apoptosis
… well as <em>in vitro</em> is the generation of reactive oxygen species (ROS). In addition, neurodegeneration is the disease of the old age that is currently affecting millions. Although the etiology of each neurodegenerative disease differs, oxidative stress has been the common factor leading to …
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Investigation of the antioxidant activity of phenolic compounds in cell culture systems
… or reduce the deleterious effects caused by reactive oxygen species (ROS) induced by UVA exposure of the skin. This study focuses on developing methods required to measure the effects of these synthesized compounds in ultraviolet radiation-exposed cultured skin cells. Biocatalytic synthesis …
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Signalling pathways involved in TNFα-induced cytoprotection : role of reactive oxygen species
Tumour necrosis factor alpha (TNFa) is a pleiotropic cytokine which has both beneficial and deleterious effects. It has previously been shown in our laboratory that TNFa can mimic ischemic preconditioning (IPC). However, the signalling pathways involved in this protection remain incompletely …
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Methodologies for the mechanistic study of compartment-specific hydrogen peroxide perturbations
Reactive oxygen species (ROS) are an interesting class of molecules because of their ability to promote contradictory phenotypes depending on their intracellular concentration. Most significantly, their elevation has been linked with several pathologies, including cancer. The selective cancer …
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PKCε and cardioprotection : an exploration of putative mechanisms
… the generation of small amounts of protective reactive oxygen species (ROS) and restoring calcium homeostasis. PKCε also interacts with adenine nucleotide translocases (ANTs), inner mitochondrial membrane proteins essential for ATP production and an integral component of the permeability …
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The redox regulation of alpha 5 beta 1 integrin stimulated MMP production in articular chondrocytes
Elevated levels of reactive oxygen species (ROS) have been observed in the cartilage of osteoarthritis (OA) patients and may contribute to the degradation of the articular cartilage extracellular matrix (ECM). ROS have been shown to serve as secondary messengers in integrin and cytokine signaling …
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Tracking Electrons Through Element Cycles: Linking Fe, C, and O Cycles Through Shared Reactive Oxygen Species
… are co-dependent through the intermediacy of reactive oxygen species (ROS), where both radical and non-radical species are potential electron carriers between Fe and C. In all but major river systems, the freshwater/saltwater mixing that occurs in a shallow aquifer system, such as the one …
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HeLa에서 K-ras 과발현시 활성산소 발생에 의한 핵모양의 이상의 발생과 이중핵/다핵 세포 증가 현상 연구
… mutants, K-RasV12 has been reported to generate reactive oxygen species (ROS). We recently observed that increased ROS generates polyploidy and abnormal nuclear shape in HeLa cells. We hypothesized that ROS generated by K-RasV12 may also generate polyploidy and abnormal nuclear shape in HeLa. We …
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Characterization of polyphenols in leaves of four desiccation tolerant plant families
… Xerophyta schlecterii, Xerophyta villosa. Craterostigma wilmsii, Craterostigma plantagineum, Craterostigma pumilum and Eragrostis nindensis. These plants are able to tolerate water stress without undergoing permanent damage. During drying these plants are subjected to different stresses and one …
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Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain
… enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. …
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Reactions of graphene oxide and buckminsterfullerene in the aquatic environment
… Aqueous graphene oxide suspensions produced reactive oxygen species (ROS), including superoxide anion (O2˙–)and hydrogen peroxide (H 2O2) when exposed to the same lamp light, under oxic conditions. The color of the GO suspension progressed from pale to dark brown during the photoreaction …
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