Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 311 for “"reactivation"”.
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Reactivation of persistant tuberculosis
… lmmunosuppression, however, may result in reactivation of active tuberculosis resulting in clinical disease. Using low dose aerosol infection of M. tuberculosis in mice, a short-duration model of rifampicin-isoniazid (RMP-INH)-induced persistent tuberculosis is described. This persistent …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
Glucosylceramide (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytosolic face of cis-Golgi and translocated to the plasma membrane and organelle lumen. The glucocerebrosidases degrade GlcCer in the cytosol and lysosome. GlcCer has been suggested to be an activator of …
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Designing a Smartwatch App for Automated Targeted Memory Reactivation
Targeted Memory Reactivation (TMR) experiments have shown potential in enhancing learning and memory by pairing sensory stimuli with specific memories during learning and reintroducing these stimuli during slow-wave sleep. This process aids in memory consolidation, where recent neural …
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Studies on the deactivation and reactivation of spent hydroprocessing catalyst
… of hydroprocessing catalysts and their reactivation by the removal of coke and metal foulants. The literature on hydrotreating catalyst deactivation by coke and metals deposition, the environmental problems associated with spent catalyst disposal, and its reactivation/rejuvenation …
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Cellular and viral factors affecting HIV-1 silencing and reactivation
… eradication by cytotoxic T cells. Optimising the reactivation signal is therefore critical to this approach. Here the established model system of latency ‘J-lat’ is used to probe optimum reactivation signals. Single clones are observed to respond to maximal stimulation with a single agent with a …
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Nutritional regulation of neural stem cell reactivation in Drosophila melanogaster
… between neural stem cell (NSC) quiescence and reactivation is a key point of regulation during neurogenesis, and in Drosophila, this process is tightly coupled to nutrient availability. Post-embryonic NSCs in Drosophila only exit quiescence when larvae are fed a diet containing essential amino …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
… and revert to a less accessible state upon reactivation. I also showed that genes necessary for neurotransmitter-based signalling become upregulated in quiescence by transitioning form H1-bound repressive heterochromatin to an active chromatin state marked by components of the SWI/SNF …
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Locus-specific proteomics identifies novel repressors of Epstein-Barr virus reactivation
… such as B-cell activation, triggers viral reactivation to a lytic state. During latent infection, the viral genome resides in the cell nucleus as an episome tethered to host chromosomes and expression of lytic genes is silenced by epigenetic mechanisms. The most important target for …
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Collisional Reactivation of Rift Margin Fracture Zones, Taiwan and the Taconic Allochthon
… I. Transverse Topographic Development due to the Reactivation of a Partially-Subducted Fracture Zone: The Southwest Hsüehshan Range, Central Taiwan</strong></p> <p><strong><em>Abstract — </em></strong>The southwest flank of the Hsüehshan Range is defined by a topographic break which cuts across …
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Functional Analysis of KAP1 Requirements for HIV-1 Transcription and Latency Reactivation
HIV-1 latency maintenance and reactivation are regulated by several viral and host factors. One such regulator is Krüppel-associated box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1β). While initial studies have revealed KAP1 to be a positive regulator of latency reversal in …
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Social Support and Viral Reactivation in US and Foreign-Born Mexican Americans
… States, have higher levels of infection and reactivation of herpesviruses that are carcinogenic or associated with cancer, and cancer is one outcome in which Hispanics do not appear to be at an advantage. To more closely understand the relationship between social support, herpesvirus …
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Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
… termed neuroblasts (NBs), are a model to study reactivation from quiescence. The Hippo and Insulin pathways were reported to promote NB quiescence and reactivation, respectively. However, the underlying mechanisms are not fully understood. This thesis describes my investigation of Monopolar …
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Enteric and hepatic glia-like cell reactivation after astrocyte-directed twinkle helicase loss
… the TwKOastro mice and controls indicating reactivation of these cells. The finding is interesting, suggesting that the tolerance of enteric glia to Twinkle loss is high. GFAP signal in the tdTomato-GFAP (tandem-dimer tomato) mouse intestine localized similarly and confirmed these results. …
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Metastatic Reactivation and Progression Result From Fak-Mediated Disruption of Innate Immune Signaling
… cells evade ensuing immune surveillance upon reactivation is poorly understood, but critical for the development of novel therapies to prevent metastatic relapse. Here, we identify focal adhesion kinase (Fak) as a critical regulator of metastatic reactivation and progression and describe a …
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Characterizing Cystoisospora canis as a Model of Apicomplexan Tissue Cyst Formation and Reactivation
… for at least 60 days. We were able to induce reactivation of MZT treated with bile-trypsin solution. In molecular studies, we characterized C. canis genetically using ITS1 and CO1 to build phylogenetic trees and found C. canis was most similar to C. ohioensis-like with ITS1 and more similar to …
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Insights Into The Reactivation, Regulation and Essentiality of Oxidative Protein Folding Pathways In Actinobacteria
… encoding-gene, confirmed defects in reactivation of MdbA. Our findings indicate these ETC components are biochemically linked to pilus assembly via oxidative protein folding.</p> <p>Because deletion of <em>mdbA </em>causes a temperature-sensitive growth and cell division defect in …
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New Constraints On the Age and Magnitude of Reactivation of the Camden Fault, South Carolina
<p>Integration of 2-D high-resolution shallow seismic reflection and refraction, gravity, 2-D electrical resistivity, Ground Penetrating Radar, and borehole data were used to image the shallow subsurface expression of the Camden fault. The preferred model for the fault geometry suggests at least 28 …
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