Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"reaction optimisation"”.
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High-Throughput Methods For Reaction Development Using The Mosquito® Liquid Handling Robot
… for quantitative data generation. The Chan-Lam reaction of an amine and aryl boronates was used as an initial proof-of-concept reaction to standardise the high-throughput protocol. All parts of the protocol were optimised including the creation of an Excel spreadsheet and Mosquito® dosing …
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A fragment based approach to the development of novel antibacterial agents inspired by the natural product simocyclinone D8
… synthesis of SD8, by exploring chlorination reactions of dihydroxycoumarins and their corresponding starting reagents. Additionally, there was a need to establish a viable route towards the complex polyketide scaffold. Secondly, to generate a library of coumarins and screen for a low …
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Active Learning-Closed-Loop Optimisation for Organic Chemistry and Formulations Research
… focuses on strategies to automate chemical reactions and conditions optimisation by employing active learning-driven closed-loop optimisation and merging algorithmic efforts with robotic technologies. First, I explored the effect of different machine-readable representations on closed- loop …
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Algorithmic Approaches for Context-Informed Reaction Prediction
… an ecosystem of tools for understanding chemical reactions is under development with the ultimate aim of accelerating lab-based workflows. This thesis makes contributions across this ecosystem of computational tools, including knowledge representation, data preparation, and model development. The …
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Studies in synthesis using CO2 and H2 gases
… metal-catalysed transformations or condensation reactions, which often require hydrolysis of the ester product to furnish the corresponding acid. In this project, a telescoped process was developed, that not only achieves CO2 activation, but exploits a novel application of the Wittig reaction, …
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The development of PCR internal controls (PICs) for forensic DNA analysis
… human DNA in a 12.5 gl PCR volume. During the reaction the IAC% and 1AC 41 0 are amplified non-competitively with ROX labelled primers, while the pre-labelled INAC80 and 1NAC 380 were not involved with the amplification process. Both sets of fragments were detected as red peaks on the …