Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 447 for “"rational design"”.
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Rational design of synthetic metalloproteins
This dissertation work focuses on the design of metal-binding a-helical coiled coils. They provide a simple yet unique model to study both metal-protein and protein-protein interactions and serve as means to gain knowledge that is required for preparation of synthetic materials with …
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The rational design of dermatological formulations
In order to understand the role of the formulation components in topical drug delivery it is necessary to separate the various contributing factors, these include thermodynamic activity effects, changes in the ionisation state of the permeant and alteration of the membrane properties. Three model …
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Toward Rational Design of Masonry Mortars
… was derived and compared to actual data. A design methodology was developed to aid in the design of masonry mortar by basing design not only on the properties of the mortar but also on its predicted behavior with the selected masonry unit.
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Rational Design for Close-Range Photogrammetry
Made available in DSpace on 2014-12-13T19:31:28Z (GMT). No. of bitstreams: 1 7616161.pdf: 7627082 bytes, checksum: 8a79bcf13814b12efbf327284108a6ae (MD5) Previous issue date: 1976
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Towards the rational design of mechanical proteins
… mechanisms contributing to the mechanical design of proteins in general. We have used a combination of computational techniques on a basis of experimental evidence to make predictions and then test them experimentally to ultimately grow our body of knowledge concerning the mechanical design …
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Towards the rational design of nanoparticle catalysts
… is focused on development of routes towards the rational design of nanoparticle catalysts. Primarily, it is focused on two main projects; (1) the use of imidazolium-based ionic liquids (ILs) as greener media for the design of quasi-homogeneous nanoparticle catalysts and (2) the rational design of …
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Rational design strategies for redox flow batteries
… space frustrates the articulation of unambiguous design criteria, as the relationships between constituent material properties and cell performance metrics are not yet well-understood. In this thesis, I address these knowledge gaps by advancing theoretical and experimental methods that support the …
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Mechanism-based rational design of cisplatin analogues
… DNA can provide invaluable insight into the rational design of cisplatin analogues or combination therapies. Chapter I provides a survey of recent developments in the understanding of the mechanism of cisplatin action and summarizes relevant platinum-based anticancer compounds. Chapter 2 …
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Rational design of hybrid organic solar cells
In this thesis, we will present a novel design for a nano-structured organic-inorganic hybrid photovoltaic material that will address current challenges in bulk heterojunction (BHJ) organic-based solar cell materials. Utilizing first principles Density Functional Theory (DFT), we show that layered …
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Rational design of hydrogen-free catalytic active sites
… well as catalytic properties are reported. Their rational molecular design and biologically inspired reactivity are based on enzymatic active sites, which are reengineered into robust metal-organic fluoroalkylated scaffolds that, for the first time, exhibit structural asymmetry and tunable …
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Rational Design of DNA-Based Lipid Membrane Pores
… in conductance and molecular weight showcase the rational design of synthetic channels inspired by the diversity of nature - from ion channels to porins.
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Rational design and development of the regenerative pump
Thesis (M.S.) Massachusetts Institute of Technology. Dept. of Mechanical Engineering, 1957.
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Rational design of microparticles for enhanced fragrance delivery
… to be utilized in industry. However, the design of these systems in industry is often conducted by costly trial-and-error experimentation. The objective of this thesis was therefore to develop a fundamental understanding of how the physical characteristics of a controlled-delivery system …
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Rational design strategies for oxide oxygen evolution electrocatalysts
… new theories and strategies can be explored for designing optimal catalysts. This work presents a framework for the rational design of transition-metal perovskite oxide catalysts that can accelerate the development of highly active catalysts for more efficient energy storage and conversion …
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Rational design of functional heme copper oxidases in myoglobin
… complex proteins, we have chosen instead to redesign an existing well-studied heme protein, myoglobin, to mimic the bimetallic, heme-CuB site of HCOs. This is the site where molecular oxygen is converted to water as part of cellular respiration. The conversion of oxygen to water is highly …
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Rational design and optimization of anti-Cdc42 peptide inhibitors
… of the peptide-protein complex informed the rational design of enhanced affinity peptides. Canonical and non-canonical amino acid substitutions were explored to modulate the peptides affinity for their target, Cdc42. A systematic N-terminal truncation library and alanine scan panel of …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
… to detect and quantify oligomers by applying a rational antibody design approach known as the cascade method. Here, we used this method to design a library of antibodies (DesAbs) systematically covering the length of wild-type tau (2N4R) and aSyn. The designed antibody sequences were grafted …
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Rational design and synthesis of new oxide ion conductors
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1996.
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Rational design of additives for inhibition of protein aggregation
… is desirable. Baynes and Trout have proposed the design of a novel class of additives called "Neutral Crowder", which does not affect the free energy of isolated protein molecules but selectively increases the free energy of the protein-protein encounter complex. They proposed that arginine can be …
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