Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 284 for “"rat model"”.
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The effect of light on a rat model of depression
… suggesting a need to improve the current animal models of depression in order to understand the basic mechanisms of the disorder. In an attempt to elucidate the pathophysiology of depression, a rodent model of depression (maternal separation, MS) is used to study the neurobiological mechanisms …
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Mesenchymal Stem Cells Therapy in Progressive Rat Model of Parkinson's Disease
… disease (PD) is a common progressive neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra (SN). In present study, we investigated the effect of human mesenchymal stem cells (hMSCs) therapy in vitro and progressive SD rat model of PD using MG-132, …
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Molecular Responses to Desialylation in a Rat Model of Induced Glomerulopathy
… adaptation of a previously described in vivo model of neuraminidase-induced glomerular injury is described in the rat. Information derived from the initial pilot studies has been used to formulate the hypothesis that loss of glomerular sialic acid, concomitant with functional glomerular …
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A study of the WKY as a rat model of depression
… - stress interaction. The Wistar - Kyoto (WKY) rat displays hypersensitivity to stress and depression - like behaviour and is used as a genetic model of major depression. However, the depression - and anxiety - like behaviour of WKY has not yet been compared between the WKY/NCrl and WKY/NHsd …
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THE EFFECTS OF BONE GRAFTING ON CALVARIAL HEALING IN A RAT MODEL
… The purpose o f this study is to 1) develop a model to study non-vascularized and vascularized calvarial grafts; and 2) compare effects o f bone graft vascularity on calvarial healing. Thirty-six rats were divided into Control and Experimental (EXP) groups. Parietal defects were left empty on …
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Obesity accelerates mammary carcinogenesis in a rat model of polygenic obesity susceptibility
… and breast cancer, we have developed a novel rat model with high relevance to the polygenic development of obesity and breast cancer in humans. These rats have differing susceptibility to obesity when fed a diet of similar macronutrient composition as that consumed by the average American …
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A Novel Transgenic Rat Model for the Study of Germ Cell Biology
… million publications in scientific journals, the rat is a very important biological model in science. Unfortunately, since the introduction of genetic manipulation technology in the mouse, extension of this technology to the rat has proven to be very difficult. In an attempt to generate a …
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Cellular and synaptic pathophysiology in a rat model of Fragile X syndrome
… X mental retardation protein (FMRP). Animal model studies over the past twenty years, mainly focusing on the Fmr1 knockout (KO) mouse, have uncovered several cellular and behavioural phenotypes associated with the loss of FMRP. Seminal work using the Fmr1 KO mouse found that metabotropic …
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Exercise and dietary interventions in a rat model of metabolic knee osteoarthritis
… this thesis was to determine the effects of moderate aerobic exercise and prebiotic fibre supplementation on the onset and progression of the metabolic knee osteoarthritis phenotype in rats exposed to a high-fat/high-sucrose diet. This study was divided into three phases. Phase 1: we evaluated …
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Collagen scaffolds for treatment of penetrating brain injury in a rat model
… is hindered by a lack of spontaneous regeneration. In injuries such as stroke and traumatic brain injury, loss of viable tissue can lead to cavitation as necrotic debris is cleared. Using a rat model of penetrating brain injury, this thesis investigated the use of collagen biomaterials to …
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PAIRING FASCIOTOMY AND SILICONE SPACER INSERTION WITH A RAT MODEL OF COMPARTMENT SYNDROME
… function. Our gr oup previously developed a ra t model of CS for exploring the pathophysiology of the condition and for testing potential treatment methods. W e sought to improve upon this rat model by better matching it to the clinical condition. CS was induced on the hindlimb of adult male Lewis …
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Neuromolecular basis of anomalous feeding behaviour in the valproate rat model of autism
… comorbidity of ASD. ASD individuals often demonstrate extreme food selectivity, refusal, dependence on few very particular food items, neophobia etc. which can lead to nutritional deficiencies affecting development. However, the underlying neurophysiological mechanisms of aberrant food intake in …
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Traumatic Brain Injury Accelerates Alzheimer’s Disease Pathology in the TgF344-AD Rat Model
… and cognitive dysfunction in the TgF344 AD rat model. Methods: Male and female TgF344-AD rats (3 months old) were randomized to receive parasagittal fluid percussion injury, sham injury, or naïve (N=10-16 rats/group). Neurobehavioral tests (beam walk, beam balance, neuroscore) were performed …
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Studies on cellular changes and amnesia in a rat model of electroconvulsive therapy
… we have studied cellular changes in an animal model of ECT - electroconvulsive seizures (ECS) - in limbic brain regions implicated in the pathophysiology of depression. In the first paper, we show that ECS enhances neuronal activation and endothelial cell proliferation in specific regions of …
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Neuroprotective Molecules and Strategies in a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
… In the development of neuroprotective strategies and translation of experimental results in HIE, there are many limitations and challenges to master based on an appropriate study design, drug delivery properties, dosage, and use in neonates. Since there are no established therapies for …
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Treatment During Abstinence from Methamphetamine in a Rat Model of Methamphetamine Use Disorder
… having anti-inflammatory action. In pre-clinical models, phosphodiesterase inhibitors can reduce behaviors associated with the self-administration of drugs of abuse if given directly before tests of relapse-like behavior. However, they have not been examined in the more clinically relevant context …
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Cytokine gene expression in a rat model of polyarthritis / by Ashley Rex Connolly.
… tissue and lymph notes draining the hind feet of rats with adjuvant arthritis (AA).
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IN VIVO DETECTION OF DOPAMINERGIC DYSFUNCTION IN A RAT MODEL OF MODERATE INTRAUTERINE ASPHYXIA
… are clinically defined as either `mild' or 'moderate' and have a more uncertain outcome. Though mild to moderate HIE is typically survivable, recent epidemiological evidence shows higher rates of cognitive/behavioral problems, and higher incidences of neurodevelopmental disorders including …
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Chondroprotective action of tart cherry in the monosodium iodoacetate (MIA) rat model of osteoarthritis
… cherry in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis (OA). Methods: A total of forty, 45-day-old female CD rats were used for study. Thirty rats were injected with MIA to induce joint destruction and randomized into three groups of 10 animals each. Rats were fed a …
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