Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"rat hippocampus"”.
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Low-Intensity Ultrasonic Neuromodulation of the Rat Hippocampus
… in the order of millimeters, the ability to penetrate deep brain regions even through a large cranium, and compatibility with MRI. Although it is known that ultrasonic pressure waves may be focused through the skull and mechanically stimulate neurons in targeted brain areas, there is considerable …
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Structural and functional heterogeneity of cells in the rat hippocampus
… is encoded in the structure and function of the hippocampus. The laminar structure and organization of information flow are well established. The dentate gyrus (DG) is the initial layer that receives and parses incoming signals. The signal is then transmitted to the CA3 and subsequently the CA1 …
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Replay of memories of extended behavior in the rat hippocampus
The hippocampus is a highly conserved structure in the medial temporal lobe of the brain that is known to be critical for spatial learning in rodents, and spatial and episodic memory in humans. During pauses in exploration, ensembles of place cells in the rat hippocampus re-express firing sequences …
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Morphological Correlates Of Synaptic Plasticity After Long Term Potentiation In The Rat Hippocampus
… neuronal morphology have been reported in the rat hippocampal formation after the induction of long-term potentiation (LTP) of the perforant path, although few studies have investigated such parameters in the maintenance phase of L-LTP. Moreover, the results of investigations of synaptic and …
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
Using the nucleated patch configuration that allowed me to investigate somatic ion channels under ideal voltage-clamp conditions, I started to examine the functional properties of Kv channels expressed in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic …
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Combinatorial analysis of sequential firing patterns across multiple neurons decoding memory of sequential spatial experience in rat hippocampus
There is broad agreement that the hippocampus is crucially involved in the formation of richly-detailed, long term memories of events in humans. A key aspect of such memories is the temporal order and spatial context of the events experienced. Evidence from a wide variety of behavioral and …
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Interactions of Thyroid Hormones and Nerve Growth Factor in Normal Development of the Rat Hippocampus and Basal Forebrain and in Recovery From Early Hypothyroid Retardation
… growth in hypothyroid animals and the robust rate of recovery is mediated by interactions of thyroid hormones with neurotrophins. We have found that hypothyroidism results in decreased hippocampal NGF levels, while up-regulating its receptors: the p75 neurotrophin and p140 trk A receptor. We …
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스트레스에 의한 Long-term potentiation (LTP)의 저하를 감소시키는 리튬의 효과
PURPOSE: The hippocampus is crucially involved in memory formation which has been known to be highly sensitive to stress. Previous studies have been show that exposure to uncontrollable stress is deleterious to hippocampus-dependent memory formation. Recent studies have demonstrated neuroprotective …
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Identifying and Predicting Rat Behavior Using Neural Networks
<p>The hippocampus is known to play a critical role in episodic memory function. Understanding the relation between electrophysiological activity in a rat hippocampus and rat behavior may be helpful in studying pathological diseases that corrupt electrical signaling in the hippocampus, such as …
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Methods for Ripple Detection and Spike Sorting During Hippocampal Replay
In the rat hippocampus, fast oscillations termed sharp wave ripples and an associated sequential firing of neurons, termed replay, have been identified as playing a crucial role in memory formation and learning. The term 'replay' is used since the observed spiking encodes patterns of past …
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Temporal synchronization of CA1 pyramidal cells by high-frequency, depressing inhibition, in the presence of intracellular noise
… extracellular recording observed in the rat hippocampus during periods of immobility. During the ripple, pyramidal cells synchronize over a short period of time despite the fact that these cells have sparse recurrent connections. Additionally, the timing of synchronized pyramidal cell …
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Glutamate Receptor-Mediated Taurine Release From The Hippocampus During Oxidative Stress
… channels (VRACs). Studies in brain slice preparations also suggest that the excitatory amino acid glutamate plays an important role in both brain tissue swelling and in cell volume regulation. We examined relationships between oxidative stress, glutamate receptor activation, cell swelling, and …
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Lead Activation of a Developmentally Regulated Calcium Channel in Rat Hippocampal Nerve Terminals
… Isolated presynaptic nerve terminals from rat hippocampus were loaded with the intracellular (Ca<sup>2+</sup>) indicator Fura-2. The changes in cytoplasmic free calcium ([Ca<sup>2+</sup>]<sub>i</sub>) were measured by stopped-flow fluorescence spectroscopy following depolarization with …
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Optogenetic regulation of protein activity in live cell
… differentiation inhibition in PC12 and primary rat hippocampus neuron cell. Next, I combined the GLIMPSe system with the Sufu protein, a SPOP phenocopy and sonic hedgehog (Shh) signaling pathway inhibitor and generated the GLIMPSe-Sufu system for optogenetic inhibition of Shh signaling pathway. …
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A Glial Role in the Action of Electroconvulsive Therapy
… with volumetric changes in prefrontal cortex, hippocampus and amygdala, brain regions known to be implicated in emotional behavior. Post-mortem analysis of brain tissue from depressed patients, have suggested that neuronal and glial pathology, seen both as changes in cellular densities and …
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Chronic mild social stress increases neurogenesis in adolescent male rats
… it is now clear that neurogenesis occurs in the rat hippocampus into adulthood. It is wellestablished that stress during adulthood decreases the rate of neurogenesis, but during adolescence, the effects of stress are much less understood. I investigated the effect of short-term or chronic stress …
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