Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"rare variant analysis"”.
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Genetic studies of cardiometabolic traits
… the discovery of thousands of trait-associated variants. Nonetheless, much is still to be understood regarding the genetic architecture of these traits, as well as their underlying biology. This thesis aims to further explore the genetic architecture of cardiometabolic traits by using …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare disease initiated by dysfunction of the pulmonary vascular endothelium. Mutations in BMPR2, which encodes the type-II bone morphogenic protein (BMP) receptor BMPR-II, explain the majority of heritable PAH. BMPR-II forms a signalling complex, with ALK1 …
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Dissecting the genetic bases of severe malaria resistance using genome-wide and post genomewide study approaches
… However, beyond identifying association variants, conventional GWAS approaches can't inform the underpinning biological functions. To bridge this gap, we applied various contemporary statistical genetic analytic approaches to malaria GWAS datasets of diverse malaria endemic populations. …