Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"rare codons"”.
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Evaluation of Altered Kras Codon Bias and NOS Inhibition During Lung Tumorigenesis
… three isoforms, <italic>KRAS contains the most rare codons resulting in lower levels of KRAS protein expression relative to <italic>HRAS and <italic>NRAS. To determine the consequences of rare codon bias during <italic>de <italic>novo tumorigenesis, we created a knock-in <italic>Kras<super>ex3op …
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Codon Usage Biases Differ Between Tissues and Can Confer Tissue-Specific Gene Expression in Drosophila
… codon usage bias. We uncover a strict limit on rare codon usage for protein expression, and this limit coincides with the rareness limit of endogenous genes in Drosophila. We find that rare codon usage near the edge of this limit is sufficient to impart tissue-specific gene expression, notably …
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A Novel, Codon-Based Approach to Preserve On-Tumor Activity and Reduce Off-Tumor Toxicity of Chimeric Antigen Receptor (CAR) T Cells
… cells.</p> <p> In our approach, we conducted rare codon engineering in Hu8F4-CAR in which select endogenous codons were strategically replaced with rare codons, or codons that are used at the lowest frequency in the human genome. In model organisms, the presence of rare codons has demonstrated …
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… same processes. The dysregulated mRNAs exhibit rare codons at the beginning of coding sequences in all three tissues, as shown in the case of the severe model of SMA. 4 From these common processes I have identified specific mRNA targets that play key roles in the organization of the …
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Commonalities between SMA and ALS: investigation of ribosome heterogeneity and translational defects
… in the 5’ untranslated region (UTR) and rare codons at the beginning of the coding sequence (CDS). SMN loss causes translational downregulation of transcripts bound by SMN-primed ribosomes (named SMN-specific mRNAs) due to ribosome-associated defects in SMA. Here, I validated these …