Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"raltegravir"”.
-
Repurposing the human immunodeficiency virus (HIV) integrase inhibitor raltegravir for the treatment of felid alphaherpesvirus 1 (FHV-1) ocular infection
… infections were reviewed. Next, the efficacy of raltegravir was evaluated using a novel corneal explant model. Raltegravir is a human immunodeficiency virus (HIV) integrase inhibitor that was recently shown to poses antiviral activity against human herpesviruses. Then, electric cell-substrate …
-
Biochemical, Structural, And Drug Design Studies Of Multi-Drug Resistant Hiv-1 Therapeutic Targets
… of the viral genome into the host chromosome. Raltegravir was the first integrase inhibitor approved by the FDA for treatment of HIV-1 infection. HIV patients on raltegravir containing regimens may develop drug resistance mutations at residue 140 and 148 in the catalytic 140's loop resulting in …
-
Toxicities associated with antiretroviral treatment of HIV-1
… plus lopinavir/ritonavir (LPV/r) or to raltegravir plus LPV/r. Results: The primary STEAL study was the first randomised controlled trial to support the finding that ABC was associated with adverse cardiovascular affects. We found there were no consistent differences in biomarker levels …
-
Synthesis and Computational Studies on Hiv-1 Integrase Inhibitors
… research has lead to the recent approval of raltegravir as the first IN inhibitor. Advancement of drug candidate elvitegravir, which is currently in Phase III clinical trial, has furthermore accelerated efforts against this potential target for combating HIV. However, the emergence of …
-
HIV Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress and Autophagy
… In hepatocytes, the integrase inhibitor raltegravir abrogated HIV PI-induced lipid accumulation by inhibiting ER stress activation and dysregulation of autophagy pathway. Our studies suggest that both ER stress and autophagy are involved in HIV PI-induced dysregulation of lipid metabolism …
-
The Role of Specific Integrase Strand Transfer Inhibitors (INSTIs) in the Alteration of Oligodendrocyte Maturation and Myelination in Hand
… if two specific INSTIs, Elvitegravir (EVG) and raltegravir (RAL), altered the survival and/or maturation of developing oligodendrocytes in vitroand in vivo. We found that treatment of oligodendrocyte precursor cells (OPCs) with EVG, but not RAL, during differentiation reduced the number of cells …
-
Diseño y caracterización de inhibidores de la fascina para el bloqueo de la invasión y la metástasis en cáncer colorrectal.
… los que caben destacar: la imipramina (IMIP), el raltegravir (RAL) y el monastrol (MON). Previamente, el grupo del Dr. HY Huang descubrió el compuesto G2 mediante screening farmacológico y lo caracterizó como un inhibidor de la fascina capaz de bloquear la migración celular, la invasión y la …